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Applied Nano
Volume 7
Issue 2
10.3390/applnano7020014
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Article

Antibacterial Effect of Nanosilver Fluoride and Silver Diamine Fluoride Against Streptococcus mutans: An In Vitro Study

by
Carlos Alonso Alvarez-Marín
1,
Norma Leticia Robles-Bermeo
2,*,
Rogelio José Scougall-Vilchis
2,*,
Raúl Alberto Morales-Luckie
3,
María Guadalupe González-Pedroza
4 and
Nayeli Lovera-Rojas
2
1
PhD Program in Health Sciences, Advanced Studies and Research Center in Dentistry Dr. Keisaburo Miyata, School of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico
2
Academic Area, Advanced Studies and Research Center in Dentistry Dr. Keisaburo Miyata, School of Dentistry, Autonomous University of the State of Mexico, Av. Jesus Carranza Esquina Paseo Tollocan S.N., Colonia Universidad CP, Toluca 50130, Mexico
3
Department of Materials Science, Center for Research in Sustainable Chemistry (CCIQS), Autonomous University of the State of México (UAEMex), Toluca 50200, Mexico
4
Department of Biotechnology, Faculty of Science, Autonomous University of the State of México (UAEMex), Toluca 50200, Mexico
*
Authors to whom correspondence should be addressed.
Appl. Nano 2026, 7(2), 14; https://doi.org/10.3390/applnano7020014
Submission received: 17 March 2026 / Revised: 30 April 2026 / Accepted: 21 May 2026 / Published: 1 June 2026
(This article belongs to the Collection Feature Papers for Applied Nano)
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Abstract

Introduction: Silver diamine fluoride (SDF) is a colorless solution used at different concentrations. It is a topical treatment used on caries lesions having as its main properties being cariostatic, remineralizing and antibacterial. Nanosilver fluoride (NSF) is effective as a cariostatic without a staining effect on the tooth surface as in the case of SDF, which generates a black stain on the treated surface. This NSF has been shown to exhibit low toxicity and continue to exhibit antimicrobial properties. Purpose: To compare the antibacterial effect of silver diamine fluoride and nanosilver fluoride against Streptococcus mutans. Methods: The NSF was prepared by starting with the synthesis of silver nanoparticles with chitosan and then adding it to a sodium fluoride (NaF) solution. The compared groups were SDF, NSF, AgNPs, NaF, and chlorhexidine. The antibacterial effect will be measured using the Kirby–Bauer microbiological technique. Results: The analysis of results was obtained using the ANOVA statistical test. A significant difference was obtained in the comparison between the groups with a value of p = 0.001. Subsequently, Tukey’s test was applied, obtaining significant differences between all the groups compared against the SDF, obtaining greater results in this group. Conclusions: Both silver diamine fluoride and nanosilver fluoride exhibit strong antibacterial activity at commercially recommended concentrations, supporting their use as optimal dental materials in both interceptive and preventive caries treatments.
Keywords: silver diamine fluoride; nanosilver fluoride; antibacterial silver diamine fluoride; nanosilver fluoride; antibacterial
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MDPI and ACS Style

Alvarez-Marín, C.A.; Robles-Bermeo, N.L.; Scougall-Vilchis, R.J.; Morales-Luckie, R.A.; González-Pedroza, M.G.; Lovera-Rojas, N. Antibacterial Effect of Nanosilver Fluoride and Silver Diamine Fluoride Against Streptococcus mutans: An In Vitro Study. Appl. Nano 2026, 7, 14. https://doi.org/10.3390/applnano7020014

AMA Style

Alvarez-Marín CA, Robles-Bermeo NL, Scougall-Vilchis RJ, Morales-Luckie RA, González-Pedroza MG, Lovera-Rojas N. Antibacterial Effect of Nanosilver Fluoride and Silver Diamine Fluoride Against Streptococcus mutans: An In Vitro Study. Applied Nano. 2026; 7(2):14. https://doi.org/10.3390/applnano7020014

Chicago/Turabian Style

Alvarez-Marín, Carlos Alonso, Norma Leticia Robles-Bermeo, Rogelio José Scougall-Vilchis, Raúl Alberto Morales-Luckie, María Guadalupe González-Pedroza, and Nayeli Lovera-Rojas. 2026. "Antibacterial Effect of Nanosilver Fluoride and Silver Diamine Fluoride Against Streptococcus mutans: An In Vitro Study" Applied Nano 7, no. 2: 14. https://doi.org/10.3390/applnano7020014

APA Style

Alvarez-Marín, C. A., Robles-Bermeo, N. L., Scougall-Vilchis, R. J., Morales-Luckie, R. A., González-Pedroza, M. G., & Lovera-Rojas, N. (2026). Antibacterial Effect of Nanosilver Fluoride and Silver Diamine Fluoride Against Streptococcus mutans: An In Vitro Study. Applied Nano, 7(2), 14. https://doi.org/10.3390/applnano7020014

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