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Abstract

Musculoskeletal Ageing—Dietary Modification of Longevity Mechanisms to Improve Skeletal Health †

Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7HE, UK
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg 25–27 March 2019.
Proceedings 2019, 11(1), 38; https://doi.org/10.3390/proceedings2019011038
Published: 24 May 2019
(This article belongs to the Proceedings of CA16112 - Luxemburg 2019)

Abstract

:
Ageing is inextricably linked to a deterioration of the musculoskeletal system. This suggests factors governing lifespan might also impact the maintenance of skeletal integrity throughout life. The Oxford Musculoskeletal Ageing group studies the causes and consequences of skeletal ageing. Recent findings indicate dietary constituents (polyphenols, omega 3 fatty acids, polyamines) have the potential to activate longevity mechanisms in vitro and prevent the onset of age-related disorders in vivo. Alterations in RedOx mediators, autophagic flux, sirtuin enzymes and senescence all contribute to an inter-linked ageing nexus manipulated by diet, to maintain health throughout life.

Funding

This article is based upon work from COST Action NutRedOx-CA16112 supported by COST (European Cooperation in Science and Technology).

Conflicts of Interest

The author declares no conflict of interest.

Share and Cite

MDPI and ACS Style

Edwards, J.R. Musculoskeletal Ageing—Dietary Modification of Longevity Mechanisms to Improve Skeletal Health. Proceedings 2019, 11, 38. https://doi.org/10.3390/proceedings2019011038

AMA Style

Edwards JR. Musculoskeletal Ageing—Dietary Modification of Longevity Mechanisms to Improve Skeletal Health. Proceedings. 2019; 11(1):38. https://doi.org/10.3390/proceedings2019011038

Chicago/Turabian Style

Edwards, James R. 2019. "Musculoskeletal Ageing—Dietary Modification of Longevity Mechanisms to Improve Skeletal Health" Proceedings 11, no. 1: 38. https://doi.org/10.3390/proceedings2019011038

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