Epigenome-Wide Effects of Vitamin D†
AbstractVitamin D3 has, via its metabolite 1,25-dihydroxyvitaminD3 (1,25(OH)2D3), a high affinity to the transcription factor vitamin D receptor (VDR), and thereby directly affects the epigenome of its target tissues. Changing the transcriptome results in modulation of physiological function, such as calcium homeostasis and the response of innate and adaptive immunity. Genome-wide datasets on the 1,25(OH)2D3-triggered binding of VDR, its pioneer factors PU.1 and CEPBA, histone markers and chromatin accessibility in THP-1 human monocytes compared to those obtained in peripheral blood mononuclear cells from vitaminD3-supplemented human volunteers (VitDbol study) allow the assessment of the epigenome-wide effects of vitamin D.
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Carlberg, C. Epigenome-Wide Effects of Vitamin D. Proceedings 2019, 11, 17.
Carlberg C. Epigenome-Wide Effects of Vitamin D. Proceedings. 2019; 11(1):17.Chicago/Turabian Style
Carlberg, Carsten. 2019. "Epigenome-Wide Effects of Vitamin D." Proceedings 11, no. 1: 17.
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