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Abstract

Epigenome-Wide Effects of Vitamin D †

by
Carsten Carlberg
School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland
†
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Proceedings 2019, 11(1), 17; https://doi.org/10.3390/proceedings2019011017
Published: 17 April 2019
(This article belongs to the Proceedings of CA16112 - Luxemburg 2019)
Versions Notes

Abstract

:
Vitamin D3 has, via its metabolite 1,25-dihydroxyvitaminD3 (1,25(OH)2D3), a high affinity to the transcription factor vitamin D receptor (VDR), and thereby directly affects the epigenome of its target tissues. Changing the transcriptome results in modulation of physiological function, such as calcium homeostasis and the response of innate and adaptive immunity. Genome-wide datasets on the 1,25(OH)2D3-triggered binding of VDR, its pioneer factors PU.1 and CEPBA, histone markers and chromatin accessibility in THP-1 human monocytes compared to those obtained in peripheral blood mononuclear cells from vitaminD3-supplemented human volunteers (VitDbol study) allow the assessment of the epigenome-wide effects of vitamin D.

Funding

This article is based upon work from COST Action NutRedOx-CA16112 supported by COST (European Cooperation in Science and Technology).

Conflicts of Interest

The authors declare no conflict of interest.

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MDPI and ACS Style

Carlberg, C. Epigenome-Wide Effects of Vitamin D. Proceedings 2019, 11, 17. https://doi.org/10.3390/proceedings2019011017

AMA Style

Carlberg C. Epigenome-Wide Effects of Vitamin D. Proceedings. 2019; 11(1):17. https://doi.org/10.3390/proceedings2019011017

Chicago/Turabian Style

Carlberg, Carsten. 2019. "Epigenome-Wide Effects of Vitamin D" Proceedings 11, no. 1: 17. https://doi.org/10.3390/proceedings2019011017

APA Style

Carlberg, C. (2019). Epigenome-Wide Effects of Vitamin D. Proceedings, 11(1), 17. https://doi.org/10.3390/proceedings2019011017

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