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Proceedings 2019, 11(1), 17; https://doi.org/10.3390/proceedings2019011017

Epigenome-Wide Effects of Vitamin D

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Published: 17 April 2019
PDF [117 KB, uploaded 17 April 2019]

Abstract

Vitamin D3 has, via its metabolite 1,25-dihydroxyvitaminD3 (1,25(OH)2D3), a high affinity to the transcription factor vitamin D receptor (VDR), and thereby directly affects the epigenome of its target tissues. Changing the transcriptome results in modulation of physiological function, such as calcium homeostasis and the response of innate and adaptive immunity. Genome-wide datasets on the 1,25(OH)2D3-triggered binding of VDR, its pioneer factors PU.1 and CEPBA, histone markers and chromatin accessibility in THP-1 human monocytes compared to those obtained in peripheral blood mononuclear cells from vitaminD3-supplemented human volunteers (VitDbol study) allow the assessment of the epigenome-wide effects of vitamin D.
Keywords: vitamin D; epigenomics; gene regulation; VDR; vitamin D intervention studies; chromatin; monocytes vitamin D; epigenomics; gene regulation; VDR; vitamin D intervention studies; chromatin; monocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Carlberg, C. Epigenome-Wide Effects of Vitamin D. Proceedings 2019, 11, 17.

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