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Abstract

Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds †

1
Biomedical Engineering Program, Enabling Technologies Division, CIMA Universidad de Navarra, 31008 Pamplona, Spain
2
Department of Pharmaceutical Science, Universidad de Navarra, 31008 Pamplona, Spain
3
Hematology and Cell Therapy Area, Clínica Universidad de Navarra and Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain
4
Centro de Investigacion Biomedica en Red de Cancer (CIBERONC) CB16/12/00489, 28029 Madrid, Spain
5
Hemato-Oncology Program, Cancer Division, CIMA Universidad de Navarra, 31008 Pamplona, Spain
6
Department for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, D-97070 Würzburg, Germany
7
Bavarian Polymer Institute, University of Bayreuth, 95447 Bayreuth, Germany
*
Author to whom correspondence should be addressed.
Presented at the 1st International Online Conference on Biomimetics (IOCB 2024), 15–17 May 2024; Available online: https://sciforum.net/event/IOCB2024.
Proceedings 2024, 107(1), 30; https://doi.org/10.3390/proceedings2024107030
Published: 15 May 2024
A wound is a defect or break in the skin caused by physical or thermal damage. Depending on the area of skin affected, there may be a series of alterations in the organism, such as blood loss, dehydration, difficulty in maintaining body temperature, or infection. The wound-healing process represents a complex series of biological events to restore the skin barrier function. Numerous studies have shown that low levels of reactive oxygen species (ROS) promote normal wound healing by stimulating cell migration and angiogenesis, but excessive ROS can occur in chronic wounds. In chronic wounds, a sustained inflammatory response leads to a large accumulation of ROS, which exceeds the physiological antioxidant capacity, impeding cell migration and proliferation and thus preventing tissue remodeling. It has been shown that antioxidants can accelerate wound healing, especially for chronic wounds. In this study, we developed a hydrogel based on a natural polymer and modified it with selenium to add antioxidant and antimicrobial properties. The synthesis reaction was confirmed with nuclear magnetic resonance (NMR) and atomic absorption spectroscopy. The mechanical properties of the hydrogel were characterized by rheological tests. Viability assays were performed with human dermal fibroblasts. Hence, we developed an antioxidant and antimicrobial hydrogel with good biocompatible properties, which seems to be a promising therapy for the treatment of chronic wounds.

Author Contributions

Conceptualization, D.P. and M.M.M.; methodology, M.P.-A.; investigation, M.P.-A.; resources, T.J., C.S., F.P. and M.M.M.; writing—original draft preparation, M.P.-A.; writing—review and editing, D.P. and M.M.M.; supervision, T.J., D.P., F.P. and M.M.M.; project administration, C.S. and F.P.; funding acquisition, C.S., F.P. and M.M.M. All authors have read and agreed to the published version of the manuscript.

Funding

This work has been supported by the European Union’s H2020 research and innovationprogramme under grant agreement 874827 (BRAV∃); Instituto de Salud Carlos III co-financed by European Regional Development Fund-FEDER “A way to make Europe” PI19/01350; Ministerio de Ciencia e Innovación CARDIOPRINT (PLEC2021-008127); Gobierno de Navarra IMPRIMED (0011-1411-2021-000096) and BIOHEART (0011-1411-2022-000071) and Gobierno de Navarra BIOGEN (PC020-021-022), and Instituto de Salud Carlos III and “Financiado por la Unión Europea–NextGenerationEU. Plan de Recuperación Transformación y Resiliencia” RICORS TERAV (RD21/0017/0009) FEDER. M.P.-A. is supported by Gobierno de Navarra with a predoctoral fellowship (0011-0537-2020-000082).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors on request.

Conflicts of Interest

The authors declare no conflict of interest.
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Share and Cite

MDPI and ACS Style

Perez-Araluce, M.; Sanmartin, C.; Prosper, F.; Jüngst, T.; Plano, D.; Mazo, M.M. Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds. Proceedings 2024, 107, 30. https://doi.org/10.3390/proceedings2024107030

AMA Style

Perez-Araluce M, Sanmartin C, Prosper F, Jüngst T, Plano D, Mazo MM. Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds. Proceedings. 2024; 107(1):30. https://doi.org/10.3390/proceedings2024107030

Chicago/Turabian Style

Perez-Araluce, Maria, Carmen Sanmartin, Felipe Prosper, Tomasz Jüngst, Daniel Plano, and Manuel M. Mazo. 2024. "Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds" Proceedings 107, no. 1: 30. https://doi.org/10.3390/proceedings2024107030

APA Style

Perez-Araluce, M., Sanmartin, C., Prosper, F., Jüngst, T., Plano, D., & Mazo, M. M. (2024). Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds. Proceedings, 107(1), 30. https://doi.org/10.3390/proceedings2024107030

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