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Open AccessArticle

Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films

Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, Brazil
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Biomimetics 2017, 2(4), 20; https://doi.org/10.3390/biomimetics2040020
Received: 10 August 2017 / Revised: 16 October 2017 / Accepted: 18 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Biomimetic Nanotechnology)
The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption. View Full-Text
Keywords: AEROSIL OX-50; dioctadecyldimethylammonium bromide; N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; elemental analysis for in situ adsorption; colloidal stability; cationic bilayer fragments; films of cationic lipids; optimal bilayer adsorption from films AEROSIL OX-50; dioctadecyldimethylammonium bromide; N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; elemental analysis for in situ adsorption; colloidal stability; cationic bilayer fragments; films of cationic lipids; optimal bilayer adsorption from films
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MDPI and ACS Style

Ribeiro, R.T.; Braga, V.H.A.; Carmona-Ribeiro, A.M. Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films. Biomimetics 2017, 2, 20. https://doi.org/10.3390/biomimetics2040020

AMA Style

Ribeiro RT, Braga VHA, Carmona-Ribeiro AM. Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films. Biomimetics. 2017; 2(4):20. https://doi.org/10.3390/biomimetics2040020

Chicago/Turabian Style

Ribeiro, Rodrigo T.; Braga, Victor H.A.; Carmona-Ribeiro, Ana M. 2017. "Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films" Biomimetics 2, no. 4: 20. https://doi.org/10.3390/biomimetics2040020

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