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Keywords = optimal bilayer adsorption from films

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12 pages, 2169 KB  
Article
Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films
by Rodrigo T. Ribeiro, Victor H. A. Braga and Ana M. Carmona-Ribeiro
Biomimetics 2017, 2(4), 20; https://doi.org/10.3390/biomimetics2040020 - 20 Oct 2017
Cited by 14 | Viewed by 5874
Abstract
The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the [...] Read more.
The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption. Full article
(This article belongs to the Special Issue Biomimetic Nanotechnology)
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