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Allergies, Volume 5, Issue 2

June 2025 - 13 articles

Cover Story: Herein, we investigate the molecular puzzle linking atopic dermatitis (AD), allergic rhinitis (AR), and chronic rhinosinusitis with nasal polyps (CRSwNP)—three interconnected type two inflammatory diseases. By integrating alterations in DNA methylation, histone modifications, and microRNAs—combined with genetic predispositions and microbial dysbiosis—that converge to drive inflammation, barrier dysfunction, and tissue remodeling across skin and airway diseases, we highlight common molecular markers such as Th2 cytokines (IL-4, IL-5, and IL-13), periostin, matrix metalloproteinases, and key regulatory miRNAs such as miR-146a and miR-155. This review underscores the promise of biologics, miRNA-targeted therapies, and MMP inhibitors in advancing personalized care. View this paper

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Articles (13)

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Article

2,184 Views

19 Pages

Aptamer-Enhanced Surface Decontamination: A Novel Approach for Neutralizing Peanut Allergens and Preventing Cell-Degranulation

Mohamad Ammar Ayass,
Trivendra Tripathi,
Natalya Griko,
Ramya Ramankutty Nair,
Tutku Okyay,
Jin Zhang,
Kevin Zhu,
Victor Pashkov and
Lina Abi-Mosleh

Allergies2025, 5(2), 11;https://doi.org/10.3390/allergies5020011

8 April 2025

Peanut allergies, driven by sensitization to key allergens Ara h1, Ara h2, and Ara h3, present significant health risks, particularly in food processing and consumer settings where accidental exposure is frequent. To mitigate this risk, we developed...

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Review

3,618 Views

14 Pages

Allergic Disorders and Systemic Lupus Erythematosus: Common Pathogenesis and Caveats in Management

Hee-Jae Jung,
Saja Mustafa Ali,
Reena Khianey and
Jamal Mikdashi

Allergies2025, 5(2), 10;https://doi.org/10.3390/allergies5020010

1 April 2025

(1) Background: Allergic disorders and systemic lupus erythematosus (SLE) are immune dysregulation conditions that are increasingly prevalent, with growing evidence suggesting shared pathogenesis. (2) Results: Patients with SLE have a higher risk of...

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Review

1 Citations

5,247 Views

26 Pages

Genetic and Epigenetic Interconnections Between Atopic Dermatitis, Allergic Rhinitis, and Rhinitis with Nasal Polyps

Alexandra Danielidi,
Spyridon Lygeros,
Alexandra Anastogianni,
Gerasimos Danielidis,
Sophia Georgiou,
Constantinos Stathopoulos and
Katerina Grafanaki

Allergies2025, 5(2), 9;https://doi.org/10.3390/allergies5020009

27 March 2025

Background: Atopic dermatitis (AD), allergic rhinitis (AR), and chronic rhinosinusitis with nasal polyps (CRSwNP) represent interconnected conditions within the spectrum of type 2 inflammatory diseases. While these conditions share common genetic and...

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Allergies - ISSN 2313-5786

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