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Non-Coding RNA
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Non-Coding RNA, Volume 9, Issue 2

April 2023 - 13 articles

Cover Story: MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression at the post-transcriptional level. MiRNAs have been found to have vital roles in various biological and pathological processes. In recent years, there has been an increase in the number of bioinformatic tools to assist in the massive demand in the field of miRNA research. Currently, such tools exist to aid researchers interested in various areas ranging from sequence annotation and validated miRNA targets to known associations with disease. Online web-based tools provide benefits to groups less experienced with programming and are regarded as more user friendly allowing accessibility to a wider range of audiences. In this brief review, such tools are categorised according to their primary purpose and will be introduced to highlight the diverse roles that miRNAs possess. View this paper
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Articles (13)

  • Communication
  • Open Access
5 Citations
4,982 Views
11 Pages
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The Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) Is under Post-Transcriptional Control of microRNAs: Analysis of the Effects of agomiRNAs Mimicking miR-145-5p, miR-101-3p, and miR-335-5p

  • Chiara Papi,
  • Jessica Gasparello,
  • Matteo Zurlo,
  • Lucia Carmela Cosenza,
  • Roberto Gambari and
  • Alessia Finotti
Non-Coding RNA2023, 9(2), 29;https://doi.org/10.3390/ncrna9020029

18 April 2023

(1) Background: MicroRNAs are involved in the expression of the gene encoding the chloride channel CFTR (Cystic Fibrosis Transmembrane Conductance Regulator); the objective of this short report is to study the effects of the treatment of bronchial ep...

Full Article
  • Editorial
  • Open Access
3 Citations
4,091 Views
10 Pages
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The Non-Coding RNA Journal Club: Highlights on Recent Papers—12

  • Patrick K. T. Shiu,
  • Mirolyuba Ilieva,
  • Anja Holm,
  • Shizuka Uchida,
  • Johanna K. DiStefano,
  • Agnieszka Bronisz,
  • Ling Yang,
  • Yoh Asahi,
  • Ajay Goel and
  • Liuqing Yang
  • + 17 authors
Non-Coding RNA2023, 9(2), 28;https://doi.org/10.3390/ncrna9020028

18 April 2023

We are delighted to share with you our twelfth Journal Club and highlight some of the most interesting papers published recently [...]

Full Article
  • Feature Paper
  • Review
  • Open Access
70 Citations
6,036 Views
31 Pages
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Targeting miRNAs and Other Non-Coding RNAs as a Therapeutic Approach: An Update

  • Emine Bayraktar,
  • Recep Bayraktar,
  • Hulya Oztatlici,
  • Gabriel Lopez-Berestein,
  • Paola Amero and
  • Cristian Rodriguez-Aguayo
Non-Coding RNA2023, 9(2), 27;https://doi.org/10.3390/ncrna9020027

13 April 2023

Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA biology has expanded substantially. miRNAs are involved and described as master regulators of the major hallmarks of cancer, including cell differentiation, prolife...

Full Article
  • Review
  • Open Access
12 Citations
5,017 Views
22 Pages
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MicroRNAs in Age-Related Proteostasis and Stress Responses

  • Latika Matai and
  • Frank J. Slack
Non-Coding RNA2023, 9(2), 26;https://doi.org/10.3390/ncrna9020026

13 April 2023

Aging is associated with the accumulation of damaged and misfolded proteins through a decline in the protein homeostasis (proteostasis) machinery, leading to various age-associated protein misfolding diseases such as Huntington’s or Parkinson&r...

Full Article
  • Article
  • Open Access
5 Citations
3,385 Views
15 Pages
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LncRNA PNKY Is Upregulated in Breast Cancer and Promotes Cell Proliferation and EMT in Breast Cancer Cells

  • Forough Hakiminia,
  • Firooz Jannat Alipoor,
  • Mostafa Keshavarz and
  • Malek Hossein Asadi
Non-Coding RNA2023, 9(2), 25;https://doi.org/10.3390/ncrna9020025

6 April 2023

Long non-coding RNAs (lncRNAs) are known to be important regulators in different cellular processes and are implicated in various human diseases. Recently, lncRNA PNKY has been found to be involved in pluripotency and differentiation of embryonic and...

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  • Article
  • Open Access
2,783 Views
15 Pages
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Liquid Biopsies Poorly miRror Renal Ischemia-Reperfusion Injury

  • Adaysha C. Williams,
  • Vaishali Singh,
  • Pengyuan Liu and
  • Alison J. Kriegel
Non-Coding RNA2023, 9(2), 24;https://doi.org/10.3390/ncrna9020024

1 April 2023

Acute kidney injury (AKI) is the rapid reduction in renal function. It is often difficult to detect at an early stage. Biofluid microRNAs (miRs) have been proposed as novel biomarkers due to their regulatory role in renal pathophysiology. The goal of...

Full Article
  • Review
  • Open Access
37 Citations
5,051 Views
14 Pages
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CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders

  • Yuka Ikeda,
  • Sae Morikawa,
  • Moeka Nakashima,
  • Sayuri Yoshikawa,
  • Kurumi Taniguchi,
  • Haruka Sawamura,
  • Naoko Suga,
  • Ai Tsuji and
  • Satoru Matsuda
Non-Coding RNA2023, 9(2), 23;https://doi.org/10.3390/ncrna9020023

31 March 2023

Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically gener...

Full Article
  • Article
  • Open Access
7 Citations
3,193 Views
11 Pages
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The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity

  • Tatiana Pavlovna Shkurat,
  • Manar Ammar,
  • Olga Bocharova,
  • Elena Teplyakova,
  • Anzhela Aleksandrova,
  • Ruba Ali and
  • Leonard Lipovich
Non-Coding RNA2023, 9(2), 22;https://doi.org/10.3390/ncrna9020022

30 March 2023

Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Imprinted Maternally Expr...

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  • Article
  • Open Access
5 Citations
3,147 Views
13 Pages
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Therapeutic Effects of WT1 Silencing via Respiratory Administration of Neutral DOPC Liposomal-siRNA in a Lung Metastasis Melanoma Murine Model

  • Martin R. Ramos-Gonzalez,
  • Eduardo Vazquez-Garza,
  • Gerardo Garcia-Rivas,
  • Cristian Rodriguez-Aguayo and
  • Arturo Chavez-Reyes
Non-Coding RNA2023, 9(2), 21;https://doi.org/10.3390/ncrna9020021

22 March 2023

The lungs represent a frequent target for metastatic melanoma as they offer a high-oxygen environment for tumor development. The overexpression of the WT1 protein has been associated with the occurrence of melanoma. In this study, we evaluated the ef...

Full Article
  • Article
  • Open Access
3 Citations
3,210 Views
19 Pages
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Reassessing the Abundance of miRNAs in the Human Pancreas and Rodent Cell Lines and Its Implication

  • Guihua Sun,
  • Meirigeng Qi,
  • Alexis S. Kim,
  • Elizabeth M. Lizhar,
  • Olivia W. Sun,
  • Ismail H. Al-Abdullah and
  • Arthur D. Riggs
Non-Coding RNA2023, 9(2), 20;https://doi.org/10.3390/ncrna9020020

17 March 2023

miRNAs are critical for pancreas development and function. However, we found that there are discrepancies regarding pancreatic miRNA abundance in published datasets. To obtain a more relevant profile that is closer to the true profile, we profiled sm...

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