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Non-Coding RNAs: Strategy for Viruses’ Offensive

Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, Italy
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
UPMC Italy (University of Pittsburgh Medical Center Italy), Discesa dei Giudici 4, 90133 Palermo, Italy
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(3), 38;
Received: 7 August 2020 / Revised: 1 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle. View Full-Text
Keywords: immune evasion; miRNA mimicry; viral circRNA; viral non-coding RNA immune evasion; miRNA mimicry; viral circRNA; viral non-coding RNA
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MDPI and ACS Style

Gallo, A.; Bulati, M.; Miceli, V.; Amodio, N.; Conaldi, P.G. Non-Coding RNAs: Strategy for Viruses’ Offensive. Non-Coding RNA 2020, 6, 38.

AMA Style

Gallo A, Bulati M, Miceli V, Amodio N, Conaldi PG. Non-Coding RNAs: Strategy for Viruses’ Offensive. Non-Coding RNA. 2020; 6(3):38.

Chicago/Turabian Style

Gallo, Alessia; Bulati, Matteo; Miceli, Vitale; Amodio, Nicola; Conaldi, Pier G. 2020. "Non-Coding RNAs: Strategy for Viruses’ Offensive" Non-Coding RNA 6, no. 3: 38.

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