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The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression

1
UNMC Summer Undergraduate Research Program, Omaha, NE 68198, USA
2
Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Non-Coding RNA 2019, 5(2), 39; https://doi.org/10.3390/ncrna5020039
Received: 28 February 2019 / Revised: 30 May 2019 / Accepted: 3 June 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Non-Coding RNA and Brain Tumors)
The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response, MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) amplification, gene copy number, and immune response, as well as correlate it to patient survival in neuroblastoma. View Full-Text
Keywords: transcribed-ultra conserved regions; microRNAs; MYCN; exosomes; metastasis; biomarkers; oncogenes; therapy resistance; neuroblastoma transcribed-ultra conserved regions; microRNAs; MYCN; exosomes; metastasis; biomarkers; oncogenes; therapy resistance; neuroblastoma
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Mudgapalli, N.; Shaw, B.P.; Chava, S.; Challagundla, K.B. The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression. Non-Coding RNA 2019, 5, 39.

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