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Asymmetric Inheritance of Cell Fate Determinants: Focus on RNA

Cell Plasticity & Epigenetics Lab, Cancer Research UK–Manchester Institute, The University of Manchester, SK10 4TG Manchester, UK
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These authors contributed equally to this work.
Non-Coding RNA 2019, 5(2), 38; https://doi.org/10.3390/ncrna5020038
Received: 26 March 2019 / Revised: 30 April 2019 / Accepted: 6 May 2019 / Published: 9 May 2019
(This article belongs to the Special Issue Non-Coding RNAs: Variations and Disease)
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Abstract

During the last decade, and mainly primed by major developments in high-throughput sequencing technologies, the catalogue of RNA molecules harbouring regulatory functions has increased at a steady pace. Current evidence indicates that hundreds of mammalian RNAs have regulatory roles at several levels, including transcription, translation/post-translation, chromatin structure, and nuclear architecture, thus suggesting that RNA molecules are indeed mighty controllers in the flow of biological information. Therefore, it is logical to suggest that there must exist a series of molecular systems that safeguard the faithful inheritance of RNA content throughout cell division and that those mechanisms must be tightly controlled to ensure the successful segregation of key molecules to the progeny. Interestingly, whilst a handful of integral components of mammalian cells seem to follow a general pattern of asymmetric inheritance throughout division, the fate of RNA molecules largely remains a mystery. Herein, we will discuss current concepts of asymmetric inheritance in a wide range of systems, including prions, proteins, and finally RNA molecules, to assess overall the biological impact of RNA inheritance in cellular plasticity and evolutionary fitness. View Full-Text
Keywords: asymmetric inheritance; heterogeneity; plasticity; RNA asymmetric inheritance; heterogeneity; plasticity; RNA
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Shlyakhtina, Y.; Moran, K.L.; Portal, M.M. Asymmetric Inheritance of Cell Fate Determinants: Focus on RNA. Non-Coding RNA 2019, 5, 38.

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