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Non-Coding RNA, Volume 4, Issue 2

June 2018 - 7 articles

Cover Story: The coding/non-coding interactome sustains complex regulatory processes in the human brain. Disturbances in this intricate balance underlie pathological states in aging and affect complex neuronal processes such as synaptic plasticity and neurogenesis. Long non-coding RNAs (lncRNAs) also seem to be particularly important in maintaining the integrity of the 3D nuclear architecture of neurons throughout the human lifespan.View Paper here.
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Articles (7)

  • Review
  • Open Access
21 Citations
5,987 Views
30 Pages

Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding...

  • Review
  • Open Access
59 Citations
9,113 Views
28 Pages

Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition

  • Almudena Expósito-Villén,
  • Amelia E. Aránega and
  • Diego Franco

Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leadi...

  • Review
  • Open Access
72 Citations
7,850 Views
25 Pages

Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity

  • Gabriel A. Cipolla,
  • Jaqueline C. De Oliveira,
  • Amanda Salviano-Silva,
  • Sara C. Lobo-Alves,
  • Debora S. Lemos,
  • Luana C. Oliveira,
  • Tayana S. Jucoski,
  • Carolina Mathias,
  • Gabrielle A. Pedroso and
  • Erika P. Zambalde
  • + 1 author

Multifactorial diseases such as cancer, cardiovascular conditions and neurological, immunological and metabolic disorders are a group of diseases caused by the combination of genetic and environmental factors. High-throughput RNA sequencing (RNA-seq)...

  • Review
  • Open Access
70 Citations
10,824 Views
23 Pages

Long Non-Coding RNAs in Neuronal Aging

  • Diana Pereira Fernandes,
  • Mainá Bitar,
  • Frank M. J. Jacobs and
  • Guy Barry

The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have contributed to more complex neuronal processes, such as higher-order cognition. In line wi...

  • Review
  • Open Access
64 Citations
9,513 Views
21 Pages

Schizophrenia is associated with diverse changes in the brain’s transcriptome and proteome. Underlying these changes is the complex dysregulation of gene expression and protein production that varies both spatially across brain regions and temp...

  • Feature Paper
  • Review
  • Open Access
53 Citations
11,986 Views
15 Pages

R-loops are evolutionarily conserved three-stranded structures that result from the formation of stable DNA:RNA hybrids in the genome. R-loops have attracted increasing interest in recent years as potent regulators of gene expression and genome stabi...

  • Article
  • Open Access
27 Citations
6,563 Views
16 Pages

Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways

  • Michelle E. Watts,
  • Sarah M. Williams,
  • Jess Nithianantharajah and
  • Charles Claudianos

Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neu...

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Non-Coding RNA - ISSN 2311-553X