Next Article in Journal
Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition
Previous Article in Journal
Long Non-Coding RNAs in Neuronal Aging
Open AccessReview

Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity

Department of Genetics, Federal University of Parana, Curitiba 81531-980, Brazil
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(2), 13; https://doi.org/10.3390/ncrna4020013
Received: 26 February 2018 / Revised: 13 April 2018 / Accepted: 4 May 2018 / Published: 11 May 2018
Multifactorial diseases such as cancer, cardiovascular conditions and neurological, immunological and metabolic disorders are a group of diseases caused by the combination of genetic and environmental factors. High-throughput RNA sequencing (RNA-seq) technologies have revealed that less than 2% of the genome corresponds to protein-coding genes, although most of the human genome is transcribed. The other transcripts include a large variety of non-coding RNAs (ncRNAs), and the continuous generation of RNA-seq data shows that ncRNAs are strongly deregulated and may be important players in pathological processes. A specific class of ncRNAs, the long non-coding RNAs (lncRNAs), has been intensively studied in human diseases. For clinical purposes, lncRNAs may have advantages mainly because of their specificity and differential expression patterns, as well as their ideal qualities for diagnosis and therapeutics. Multifactorial diseases are the major cause of death worldwide and many aspects of their development are not fully understood. Recent data about lncRNAs has improved our knowledge and helped risk assessment and prognosis of these pathologies. This review summarizes the involvement of some lncRNAs in the most common multifactorial diseases, with a focus on those with published functional data. View Full-Text
Keywords: complex diseases; lncRNAs; biomarkers complex diseases; lncRNAs; biomarkers
Show Figures

Graphical abstract

MDPI and ACS Style

Cipolla, G.A.; De Oliveira, J.C.; Salviano-Silva, A.; Lobo-Alves, S.C.; Lemos, D.S.; Oliveira, L.C.; Jucoski, T.S.; Mathias, C.; Pedroso, G.A.; Zambalde, E.P.; Gradia, D.F. Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity. Non-Coding RNA 2018, 4, 13.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop