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Non-Coding RNA 2018, 4(2), 13; https://doi.org/10.3390/ncrna4020013

Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity

Department of Genetics, Federal University of Parana, Curitiba 81531-980, Brazil
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Received: 26 February 2018 / Revised: 13 April 2018 / Accepted: 4 May 2018 / Published: 11 May 2018
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Abstract

Multifactorial diseases such as cancer, cardiovascular conditions and neurological, immunological and metabolic disorders are a group of diseases caused by the combination of genetic and environmental factors. High-throughput RNA sequencing (RNA-seq) technologies have revealed that less than 2% of the genome corresponds to protein-coding genes, although most of the human genome is transcribed. The other transcripts include a large variety of non-coding RNAs (ncRNAs), and the continuous generation of RNA-seq data shows that ncRNAs are strongly deregulated and may be important players in pathological processes. A specific class of ncRNAs, the long non-coding RNAs (lncRNAs), has been intensively studied in human diseases. For clinical purposes, lncRNAs may have advantages mainly because of their specificity and differential expression patterns, as well as their ideal qualities for diagnosis and therapeutics. Multifactorial diseases are the major cause of death worldwide and many aspects of their development are not fully understood. Recent data about lncRNAs has improved our knowledge and helped risk assessment and prognosis of these pathologies. This review summarizes the involvement of some lncRNAs in the most common multifactorial diseases, with a focus on those with published functional data. View Full-Text
Keywords: complex diseases; lncRNAs; biomarkers complex diseases; lncRNAs; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cipolla, G.A.; de Oliveira, J.C.; Salviano-Silva, A.; Lobo-Alves, S.C.; Lemos, D.S.; Oliveira, L.C.; Jucoski, T.S.; Mathias, C.; Pedroso, G.A.; Zambalde, E.P.; Gradia, D.F. Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity. Non-Coding RNA 2018, 4, 13.

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