Next Article in Journal
Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity
Next Article in Special Issue
Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain
Previous Article in Journal / Special Issue
Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Non-Coding RNA 2018, 4(2), 12; https://doi.org/10.3390/ncrna4020012

Long Non-Coding RNAs in Neuronal Aging

1
University of Amsterdam, Swammerdam Institute for Life Sciences (SILS), 1098XH Amsterdam, The Netherlands
2
QIMR Berghofer Medical Research Institute, Herston, QLD, Brisbane, Australia
*
Authors to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 6 April 2018 / Accepted: 10 April 2018 / Published: 18 April 2018
(This article belongs to the Special Issue Non-Coding RNA in the Nervous System)
Full-Text   |   PDF [2229 KB, uploaded 3 May 2018]   |  

Abstract

The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have contributed to more complex neuronal processes, such as higher-order cognition. In line with the important roles of lncRNAs in the normal functioning of the human brain, dysregulation of lncRNA expression has been implicated in aging and age-related neurodegenerative disorders. In this paper, we discuss the function and expression of known neuronal-associated lncRNAs, their impact on epigenetic changes, the contribution of transposable elements to lncRNA expression, and the implication of lncRNAs in maintaining the 3D nuclear architecture in neurons. Moreover, we discuss how the complex molecular processes that are orchestrated by lncRNAs in the aged brain may contribute to neuronal pathogenesis by promoting protein aggregation and neurodegeneration. Finally, this review explores the possibility that age-related disturbances of lncRNA expression change the genomic and epigenetic regulatory landscape of neurons, which may affect neuronal processes such as neurogenesis and synaptic plasticity. View Full-Text
Keywords: lncRNAs; aging; cognition; neurogenesis; age-related diseases; neurodegeneration; antisense transcript; nuclear architecture; transposable element lncRNAs; aging; cognition; neurogenesis; age-related diseases; neurodegeneration; antisense transcript; nuclear architecture; transposable element
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Pereira Fernandes, D.; Bitar, M.; Jacobs, F.M.J.; Barry, G. Long Non-Coding RNAs in Neuronal Aging. Non-Coding RNA 2018, 4, 12.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Non-Coding RNA EISSN 2311-553X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top