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Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways

Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Monash Bioinformatics Platform, Monash University, Melbourne VIC 3800, Australia
The Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Melbourne VIC 3052, Australia
Centre for Mental Health Research, The Australian National University, Canberra ACT 2601, Australia
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(2), 10;
Received: 28 February 2018 / Revised: 22 March 2018 / Accepted: 26 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue Non-Coding RNA in the Nervous System)
Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington’s, Alzheimer’s, and Parkinson’s diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210. View Full-Text
Keywords: microRNA; hsa-miR-210; microRNA targeting; SH-SY5Y cells; neurodegeneration microRNA; hsa-miR-210; microRNA targeting; SH-SY5Y cells; neurodegeneration
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Watts, M.E.; Williams, S.M.; Nithianantharajah, J.; Claudianos, C. Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways. Non-Coding RNA 2018, 4, 10.

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