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Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia

The Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia
The Department of Psychiatry, the University of Melbourne, Parkville, VIC 3010, Australia
The Centre for Mental Health, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(2), 11;
Received: 14 March 2018 / Revised: 29 March 2018 / Accepted: 6 April 2018 / Published: 12 April 2018
(This article belongs to the Special Issue Non-Coding RNA in the Nervous System)
Schizophrenia is associated with diverse changes in the brain’s transcriptome and proteome. Underlying these changes is the complex dysregulation of gene expression and protein production that varies both spatially across brain regions and temporally with the progression of the illness. The growing body of literature showing changes in non-coding RNA in individuals with schizophrenia offers new insights into the mechanisms causing this dysregulation. A large number of studies have reported that the expression of microRNA (miRNA) is altered in the brains of individuals with schizophrenia. This evidence is complemented by findings that single nucleotide polymorphisms (SNPs) in miRNA host gene sequences can confer an increased risk of developing the disorder. Additionally, recent evidence suggests the expression of other non-coding RNAs, such as small nucleolar RNA and long non-coding RNA, may also be affected in schizophrenia. Understanding how these changes in non-coding RNAs contribute to the development and progression of schizophrenia offers potential avenues for the better treatment and diagnosis of the disorder. This review will focus on the evidence supporting the involvement of non-coding RNA in schizophrenia and its therapeutic potential. View Full-Text
Keywords: schizophrenia; central nervous system; microRNA; lncRNA; snoRNA; biomarkers schizophrenia; central nervous system; microRNA; lncRNA; snoRNA; biomarkers
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Gibbons, A.; Udawela, M.; Dean, B. Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia. Non-Coding RNA 2018, 4, 11.

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