Special Issue "Genomic Instability and Non-Coding RNA"
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (15 October 2018).
Interests: Long non-coding RNA, genomic instability, enhancers, superenhancers, 3D genomes, somatic mutations, genome rearrangements
Interests: DNA damage, transcription regulation, Senataxin, R loops, neurodegenerative disorders, AOA2, ALS4
Intergenic and intragenic regions of the mammalian genome are organized inside topologically-associated regulatory domains (TADs) that express various types of noncoding RNAs (ncRNAs). These ncRNAs are associated with bi-directionally transcribed promoters, enhancers and intragenic antisense RNA expressing units. Recent studies have indicated these noncoding RNAs could also play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. However, the transcription and stabilization of these ncRNAs could also lead to genomic instability due to formation of deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote transcription complex stalling that eventually lead to collisions of transcription complexes with replisomes. Thus, ncRNA biogenesis and surveillance may play a vital role in determining the organization, function and stability of the mammalian genome. Finally, many noncoding RNAs that are able to survive the interrogation of the RNA surveillance machinery control gene expression via trans-acting regulatory mechanisms in the nucleus and cytoplasm of mammalian cells. In this Special Issue of Noncoding RNA we invite many experts in the field of RNA biology to present their point of view on various aspects of ncRNA transcription, function, regulation and surveillance.
Dr. Uttiya Basu
Dr. Patricia Richard
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- noncoding RNA
- bidirectional transcription
- long intergenic noncoding RNA
- antisense RNA
- enhancer–superenhancer, R-loops
- DNA/RNA secondary structures
- replisome/transcription complex collisions
- DNA mutations
- DNA translocations
- DNA damage repair
- histone and chromatin modifications
- chromatin states