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Non-Coding RNA 2018, 4(2), 15; https://doi.org/10.3390/ncrna4020015

Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain

Cognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia
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Received: 17 April 2018 / Revised: 23 May 2018 / Accepted: 30 May 2018 / Published: 7 June 2018
(This article belongs to the Special Issue Non-Coding RNA in the Nervous System)
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Abstract

Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding RNAs are directly involved in the post-transcriptional modification of other RNA species, while others are themselves substrates for modification, or are functionally modulated by modification of their target RNAs. In this review, we explore the known and potential functions of several distinct classes of small non-coding RNAs in the mammalian brain, focusing on the newly recognised interplay between the epitranscriptome and the activity of small RNAs. We discuss the potential for this relationship to influence the spatial and temporal dynamics of gene activation in the brain, and predict that further research in the field of epitranscriptomics will identify interactions between small RNAs and RNA modifications which are essential for higher order brain functions such as learning and memory. View Full-Text
Keywords: epitranscriptomics; neurobiology; non-coding RNA; small RNA epitranscriptomics; neurobiology; non-coding RNA; small RNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Leighton, L.J.; Bredy, T.W. Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain. Non-Coding RNA 2018, 4, 15.

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