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Journal of Fungi, Volume 9, Issue 8
2023 August - 83 articles
Cover Story: Invasive aspergillosis (IA) is a major cause of mortality in patients receiving allo-HCT. It is, therefore, paramount to understand why treatment of IA caused by azole-susceptible isolates is often unsuccessful. We present two haematological patients with proven IA who suffered treatment failure, despite carrying susceptible isolates, receiving correct antifungal treatment and reaching therapeutic levels of the azole. Micologycal analyses showed that the patients were infected with multiple strains, several of which were persisters to voriconazole and/or isavuconazole. We propose that azole persistence in A. fumigatus has a role in treatment failure, and hence, azole persistence might be a relevant and underestimated factor that could influence the outcome of infection in human aspergillosis. View this paper
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J. Fungi - ISSN 2309-608X