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Journal of Fungi, Volume 8, Issue 4
April 2022 - 93 articles
Cover Story: Mucormycosis is a life-threatening disease caused by Mucoromycota species such as Rhizopus delemar. Mucormycosis is most effectively treated with amphotericin B (AmB) and particularly with AmB-loaded liposomes (AmB-LLs). However, even after treatment, there is still a 50% mortality rate. We used the pathogen receptor Dectin-1 to target AmB-LLs to R. delemar. DEC1-AmB-LLs bound with great efficiency to exopolysaccharide matrices associated with sporangiospores, germlings, and mature hyphae. DEC1-AmB-LLs delivering sub-micromolar concentrations of AmB were an order of magnitude more efficient at inhibiting or killing R. delemar than AmB-LLs. The cover image shows rhodamine B-tagged DEC1-AmB-LLs (red) that are bound to calcofluor white-stained R. delemar germlings (green). View this paper
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J. Fungi - ISSN 2309-608X