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Journal of Fungi, Volume 11, Issue 6
June 2025 - 64 articles
Cover Story: Oxidative stress is a key immune defense mechanism against fungal infections such as sporotrichosis, caused by Sporothrix schenckii. Phagocytic cells recognize fungal PAMPs via pattern recognition receptors (PRRs), triggering immune responses including the production of reactive oxygen species (ROS) to eliminate the pathogen. However, S. schenckii evades this defense mechanism through antioxidant enzymes, cell wall modifications, melanin production, and moonlighting proteins that contribute to immune evasion and stress resistance. These strategies, combined with gene expression modulation, enable fungal survival and infection persistence. Understanding these interactions is crucial for developing effective therapies. View this paper
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J. Fungi - ISSN 2309-608X