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Journal of Fungi, Volume 11, Issue 12
December 2025 - 74 articles
Cover Story: Coccidioidomycosis (CM), also known as Valley Fever, is endemic to the alkaline deserts of North and South America. Inhalation of spores from the causative agents Coccidioides immitis and Coccidioides posadasii often presents as flu-like symptoms or pneumonia. Severe disseminated CM, while rare, often requires long-term antifungal treatment. Current CM treatments focus on azoles, such as fluconazole and itraconazole, and the polyene amphotericin B. However, due to the concern of polyene cytotoxicity and evolving azole-resistant fungal strains, development of new antifungals against CM is urgently needed. This review highlights the limitations of current antifungal treatments and the efforts to address the gap through surveys of emerging antifungal compounds undergoing clinical trials and drug repurposing via high-throughput screening. View this paper
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J. Fungi - ISSN 2309-608X