Next Article in Journal
Onychomycosis: Old and New
Next Article in Special Issue
Application of Real-Time PCR Assays for the Diagnosis of Histoplasmosis in Human FFPE Tissues Using Three Molecular Targets
Previous Article in Journal
Indigenous Yeasts for the Biocontrol of Botrytis cinerea on Table Grapes in Chile
Previous Article in Special Issue
Detection of Cytokines and Collectins in Bronchoalveolar Fluid Samples of Patients Infected with Histoplasma capsulatum and Pneumocystis jirovecii
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JoF
Volume 9
Issue 5
10.3390/jof9050558
jof-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions

by
Diego H. Cáceres
1,2,3,*,
Beatriz L. Gómez
2,
Ángela M. Tobón
4,
Ángela Restrepo
5,†,
Tom Chiller
6,
Mark D. Lindsley
6,
Jacques F. Meis
1,7 and
Paul E. Verweij
1
1
Center of Expertise in Mycology Radboudumc/Canisius Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands
2
Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota 111221, Colombia
3
IMMY, Norman, OK 73069, USA
4
Instituto Colombiano de Medicina Tropical, Universidad CES, Medellín 055450, Colombia
5
COLCIENCIAS Emeritus Researcher, Ministerio de Ciencias, Tecnología e Innovación, Bogota 111321, Colombia
6
Mycotic Diseases Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30329, USA
7
Department I of Internal Medicine, Excellence Center for Medical Mycology, University Hospital Cologne, 50931 Cologne, Germany
*
Author to whom correspondence should be addressed.
†
Deceased.
J. Fungi 2023, 9(5), 558; https://doi.org/10.3390/jof9050558
Submission received: 9 April 2023 / Revised: 4 May 2023 / Accepted: 5 May 2023 / Published: 11 May 2023
(This article belongs to the Special Issue Histoplasma and Histoplasmosis 2023)
Review Reports Versions Notes

Abstract

:
Histoplasmosis, caused by the thermally dimorphic fungus Histoplasma spp., is a disease with a broad clinical spectrum, presenting from asymptomatic/flu-like symptoms to progressive disseminated disease in people with immunosuppression. In recent years, the concept of histoplasmosis as a disease restricted to the American continent has changed, as now histoplasmosis is reported in many regions around the world. In Latin America, histoplasmosis represents a threat, especially in people with advanced HIV disease (AHD). Diagnosis of histoplasmosis in people living with HIV (PLHIV) is challenging due to the low index of suspicion of the disease, non-specificity of signs and symptoms, and limited access to specific laboratory testing, while the diagnostic delay is significantly associated with mortality. In the last decade, novel diagnostic tests have been developed for the rapid detection of histoplasmosis, such as commercial kits for antigen detection. Furthermore, advocacy groups were created that presented histoplasmosis as a public health problem, with emphasis on patients at risk of progressive disseminated disease. This review aims to discuss the impact of histoplasmosis associated with AHD in Latin America and the strategies employed to tackle histoplasmosis, from the implementation of laboratory testing to disease advocacy and public health interventions.

1. Histoplasma spp.

The Histoplasma genus is composed of two species: H. capsulatum and H. farciminosum. H. capsulatum has two varieties associated with disease in humans: H. capsulatum var. capsulatum, which is globally distributed, and H. capsulatum var. duboisii, which is restricted to the African continent [1,2]. The second species, H. farciminosum, is recognized for causing disease in horses in the African continent [1,2]. In recent years, with evolving taxonomic insights, the reclassification of H. capsulatum has been proposed. The most widely used classification by Kasuga et al. [3] is based on multi-locus sequence typing (MLST). It divides H. capsulatum into eight clades, including two clades in North America: class 1 clade and class 2 clade (clades i and ii); two Latin American clades, group A clade and group B clade (clades iii and iv); an Australian clade (clade v); the Netherlands (Indonesian?) clade (clade vi); the Eurasian clade (vii); and the African clade (viii). Seven of eight clades represent groups that may be recognized as phylogenetic species. The African clade includes all H. capsulatum var. duboisii individuals [3]. More recently, Sepulveda et al. proposed dividing H. capsulatum var. capsulatum into four species using whole-genome sequencing. Based on the results, the authors proposed the following species: (i) Histoplasma capsulatum sensu stricto Darling 1906, (ii) Histoplasma mississippiense sp. nov., (iii) Histoplasma ohiense sp. nov., and (iv) Histoplasma suramericanum sp. nov. [4]. It is important to mention that at the time of writing this review, these reclassifications have not been validated, and approval of this new classification is still in discussion [5].

2. Histoplasmosis

Histoplasmosis is acquired when the host is exposed to an environment that contains the infective particles of the fungus, micro-conidia, and fragments of hyphae [6]. Infection can be acquired by inhalation of these infective particles due to disruption of contaminated soil that is enriched with bird and bat guano or as a result of work or recreational activities [7]. Histoplasmosis is not transmitted from person to person, although transmission through organ transplantation has been reported rarely [8,9]. After the inhalation of infective particles, a primary lung infection may develop [6]. Subsequently, the fungus may spread from the lung to other organs of the reticuloendothelial system by hematogenous dissemination [6]. More than 95% of infections resolve spontaneously, primarily in hosts without alteration of the immunological response and those exposed to a low burden of infective particles [6,10,11]. However, in most patients, the fungus is not eliminated, and the fungus then persists for many years in a latent state and is able to reactivate [6,10]. The clinical manifestations of histoplasmosis depend on various factors such as the inoculum inhaled during the environmental exposure, lung integrity, or immunological alterations present in the patient at the time of exposure [10,11]. These factors were considered by Goodwin et al., who proposed a classification for histoplasmosis in 1981 [11]. This classification aimed to combine epidemiological and clinical characteristics to classify disease stages and support treatment choice.
The first reported cases of histoplasmosis were identified in the early 20th century in Panama by the American pathologist Samuel Taylor Darling, during the time he worked at the Panama Canal. The first case in 1905 was a 27-year-old male from Martinique who worked on the Panama Canal construction and developed a fulminant disseminated disease. Darling observed in this patient that the lungs were studded with granulomas, resembling miliary tuberculosis. He also found granulomas in the spleen, liver, and bone marrow. Surprisingly, in 1906 a second Panama Canal worker who was also from Martinique presented with the same disseminated disease. The third case was in a Chinese immigrant who had been a resident in Panama for 15 years and showed similar microorganisms in histopathological analysis. Initially, Darling classified this disease as a protozoal infection, but in 1912, the disease was reclassified from a protozoal to a fungal disease by Henrique da Rocha-Lima, a pathologist and infectious disease physician from Brazil, who based this reclassification on a comparison of Leishmania and Histoplasma [12,13,14,15]. In 1933, William A. DeMonbreun isolated Histoplasma from a clinical human specimen for the first time [14,15], and in 1948, Chester W. Emmons isolated Histoplasma from soil samples [14,15]. In the early 1950s investigators from Suriname isolated Histoplasma from human, animal, and environmental samples [16,17,18]. These early observations in the 1950s from Suriname and Guyana in humans and animals did not generate attention; consequently, in the early 1960s, many Dutch military personnel stationed in Suriname were wrongly diagnosed with tuberculosis, but in retrospect had histoplasmosis [19,20,21].
In the 1960s, Leo Kaufman and the staff of the US Centers for Disease Control and Prevention (CDC) Mycotic Diseases Branch standardized the first immunodiagnostics assays for anti-Histoplasma antibodies (Ab) detection [22]. In 1986, Lawrence J. Wheat developed the first assay for Histoplasma antigen (Ag) detection in urine and serum, and in 2002 Ralf Bialek developed the first PCR protocols for detection of Histoplasma DNA in human tissues [23,24]. Before the 1980s, sporadic reports from Latin American countries described histoplasmosis cases, even though multiple seroprevalence studies using intradermal reactivity with histoplasmin were conducted in the region, demonstrating high rates of skin reaction in the general population [25,26]. This changed after the beginning of the HIV pandemic.
Since the first report of histoplasmosis in Panama in 1906, this disease has been described worldwide, with the highest frequency in the American continent. However, in recent years, histoplasmosis has evolved from a geographically restricted endemic mycosis to a global disease, with cases increasingly described in Africa and Asia. This increasing trend may be partly the result of greater disease awareness and the development and use of more accurate diagnostic assays [13,27].

3. Histoplasmosis and HIV

The term progressive disseminated histoplasmosis (PDH) refers to one of the clinical forms of histoplasmosis characterized by the inability of the host immune system to control the fungal infection [28,29]. In immunosuppressed hosts, histoplasmosis can be the result of a primary infection or a reactivation of a prior infection. Reactivation may occur in individuals who reside or were residents in regions where the fungus is in the environment [6,28,29]. Following the start of the AIDS epidemic, several patients with AIDS in the Netherlands, who originated from Suriname, presented with disseminated histoplasmosis, which was not surprising considering the previously described presence of Histoplasma in Suriname [30]. This pattern has been seen in many Latin American areas since 1987, where more than 90% of reported cases of PDH have occurred in patients with advanced HIV disease, leading the CDC to recognize this disease as an HIV opportunistic infection [31].
Since 2017, the World Health Organization (WHO) had released recommendations for rapid initiation of antiretroviral treatment (ART) in all people living with HIV (PLHIV) [32]. PLHIV with advanced disease are at elevated risk of developing histoplasmosis, especially those living in regions endemic for this disease [33]. Clinical signs and symptoms of histoplasmosis are non-specific in these patients, and accurate diagnosis of histoplasmosis is difficult, as is differentiation from coinfections with other opportunistic pathogens, such as mycobacteria [34]. Co-infections in PLHIV with histoplasmosis have been reported in up to 50% of cases and reports of co-occurrence with mycobacterial disease have ranged from 2% to 35% in Latin American countries, underscoring the need for adequate laboratory diagnostics [35,36,37,38].
For the Latin America region, histoplasmosis is among the most prevalent opportunistic infections affecting PLHIV [39]. This disease has been associated with high mortality rates in different cohorts of PLHIV that develop disseminated histoplasmosis (up to 30% mortality) [40]. For 2012, the estimated burden of histoplasmosis in PLHIV in Latin America ranged from 6710 to 15,657 cases per year. In some countries the prevalence and mortality associated with histoplasmosis was equivalent or higher than that of TB [26]. Based on this estimation, authors have concluded that histoplasmosis is a neglected disease among opportunistic infections caused by fungal pathogens in PLHIV in the Americas and could be responsible for a significant proportion of annual PLHIV deaths [26]. In Guatemala, in 2017, of 1953 PLHIV who were evaluated in a prospective cohort, 317 (16%) patients were diagnosed with opportunistic infections. Of those, 36% had tuberculosis (TB), 31% had histoplasmosis, 19% had cryptococcosis, 4% had nontuberculous mycobacterial disease, and 10% presented with coinfections. Histoplasmosis was the most frequent defining manifestation of advanced HIV in this cohort [41].
Nevertheless, some progress has been made in recent years, including the publication of WHO/Pan American Health Organization (PAHO) guidelines for the diagnosis and management of disseminated histoplasmosis in PLHIV [42], the development, validation, and commercial availability of kits for rapid detection of Histoplasma antigen in human specimens [43,44], and the inclusion of these rapid assays in the second WHO model list of essential in vitro diagnostics [45]. WHO histoplasmosis guidelines also present recommendations for treatment, including the use of liposomal amphotericin for induction therapy in patients with severe or moderately severe disease. Guidelines for these patients recommend the use of itraconazole for 12 months for maintenance therapy; shorter therapy could be considered if the patient is clinically stable and if their immune status has improved. These guidelines also recommend the rapid initiation of ART and describe recommendations for the treatment of co-infection with TB.
In addition, based on public health importance, global burden, and existing knowledge gaps, Histoplasma spp. has been recently recognized as a WHO fungal priority pathogen [46]. These achievements will help to estimate the real burden of histoplasmosis in PLHIV.

4. Diagnosis of Histoplasmosis in PLHIV

Symptoms of PDH are often nonspecific, and among patients with advanced HIV disease they resemble those of other infectious diseases, especially TB, complicating diagnosis and treatment [26,34,38]. Delayed treatment of histoplasmosis is a major cause of mortality (approximately 30% in PLHIV) [39,40]. Conventional laboratory methods used for diagnosing histoplasmosis, such as culture and histopathology, pose many challenges, including the need for complex laboratory infrastructure and experienced staff with mycology training, a long turnaround time of up to several weeks, and variable assay sensitivity, 72% to 81% (Table 1) [47]. Diagnosis using conventional serologic methods is further complicated by a reduction in antibody test sensitivity (38–70%) when performed in immunocompromised individuals (Table 1) [47].
Detection of circulating antigen in urine or sera has been described as the best choice to diagnose PDH in PLHIV [42,47,48]. A systematic review and meta-analysis compared the accuracy of different diagnostic assays for the diagnosis of histoplasmosis in PLHIV [47]. In this meta-analysis, antigen detection assays in urine and sera showed the highest performance in detecting histoplasmosis in PLHIV (pooled sensitivity, 95%, and pooled specificity, 97%) (Table 1) [47]. Advantages of antigen assay include its commercial availability and the ability to be implemented in a laboratory with lower-level biosecurity (levels 1 and 2). In addition, antigens are present only during active disease, unlike antibodies, which are detected long after infection has been resolved. The review and meta-analysis also indicated that molecular testing may be a desirable alternative for correct diagnosis of histoplasmosis in PLHIV [47]. However, a lack of commercially available kits and standardized methods, and the limited number of validation studies, limit their broad use in clinical microbiology laboratories [47]. It has yet to be determined which DNA extraction method, gene target and primers, or amplification methodology is optimal; it will likely vary for culture confirmation and direct detection in patient specimens [47]. Furthermore, the 2020 EORTC/MSGERC definitions of invasive fungal diseases do not include molecular detection assays as methods for the diagnosis of endemic mycoses due to a lack of consensus on gene targets and laboratory protocols for molecular assays [49]. Further investigations, laboratory consensus, and development of commercial kits are needed.

5. Histoplasmosis in PLHIV in Latin America

A literature review was conducted using PubMed Central and LILACS. The searches were limited to those studies published in English, Spanish, and Portuguese, and used as search terms histoplasmosis AND HIV and terms including their synonyms. We included case series or cohort studies from Latin American countries that described a minimum of ten histoplasmosis cases. Studies were excluded if they were not focused on human or environmental studies or if they constituted literature reviews. A total of 34 papers describing cases series or cohort studies involving PLHIV with histoplasmosis were identified [37,38,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80]. These papers describe cases from Central American countries, including El Salvador, Guatemala, Honduras, Nicaragua, and Panama, and South American countries, including Argentina, Brazil, Colombia, French Guiana, and Peru, between the early 1980s and 2021, and together they present data for 3649 cases of histoplasmosis associated with HIV [37,38,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81]. Brazil was the country with the most publications, n = 14, and cases, n = 1106 (30%). Studies from Guatemala presented data from 710 cases, including 561 cases reported in the last decade (79% of cases). Colombia and French Guiana presented similar numbers of patients, n = 510 and n = 506, respectively (Table 2) [37,38,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81]. In most of these reports, the cases were diagnosed by conventional laboratory tests, microscopy/histopathology, and culture (26 of 35 studies; 74%) [37,38,50,52,55,56,57,58,59,60,61,62,63,64,65,66,67,71,72,73,74,76,77,78,79,80]. Studies that used Histoplasma Ag testing in urine, n = 9, were mostly conducted after 2014 [51,53,54,68,69,70,74,75,81]. These studies described 1169 of the 3649 histoplasmosis cases reported (32%). In addition, the studies involving the use of Ag testing were characterized by increasing case detection, especially when data were compared with prior statistics of cases diagnosed by a conventional test such as microscopy and culture, increasing the diagnostic yield, in some reports doubling the number of diagnosed cases, or representing the first cases reporting in the country literature [51,54,70,74].
Co-infections were common in 20 of 35 studies, and co-infection rates ranged from 14% to 100%. Histoplasmosis-TB co-infection was also common, reported in 14 studies, with frequency ranging from 18% to 65% of patients with multiple infections (Table 2) [37,38,51,52,53,55,57,58,60,63,64,68,69,70,72,73,75,76,77,79,80,81]
These publications reported variable mortality rates, between 6% to 57% [37,38,50,51,52,53,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,72,73,75,76,77,78,79,80,81]. Two studies that tracked patient mortality over time concluded that a decrease in mortality was observed. The first study from French Guiana described 34 years of experience diagnosing histoplasmosis. In this study, 349 histoplasmosis cases were analyzed, and a crude mortality of 41% over the three decades was observed. In addition, this study analyzed 30-day mortality in four periods: before 1998; 1999 to 2003; 2004 to 2009; and 2010 to 2014. Before 1998, mortality was 38%. From 1999 to 2003, mortality decreased to 17%, probably because of the introduction of ART. In the third and fourth periods, the mortality declines continued to 9% and 6%, respectively. Authors from French Guiana concluded that this decreasing trend was due to progress in adequate HIV care and an increase in awareness and exhaustive laboratory testing for histoplasmosis in French Guiana over the last two decades [76]. The second report, from Guatemala, reported on the implementation of a screening program. During this program, mortality among newly diagnosed HIV patients decreased from 33% in 2017 to 21% in 2019 [51]. This program assessed patients at risk, regardless of the presence of symptoms, and testing was mostly conducted using Histoplasma Ag detection in urine [51].
In addition, two more studies have shown how the use of urinary Histoplasma Ag detection impacted patients’ mortality. The first, a multicenter study from Guatemala and El Salvador, reported a lower 30-day mortality in patients who were tested for Histoplasma Ag, regardless of positive or negative results. Mortality was 13% among patients who underwent testing compared with 75% in patients who were not tested [53]. Another multicenter study from Brazil also showed a benefit of Ag testing, with a 14% mortality rate in individuals tested with the Ag detection assay compared to 27% in those who underwent conventional testing [70].
Several studies identified factors that were associated with mortality in PLHIV with histoplasmosis. These factors include: creatinine > 2.1 mg/dL, albumin concentration < 3.5 g/dL, dyspnea, platelet count <100,000 cell-per-mm3, lactate dehydrogenase concentration elevated to twice the normal value, hemoglobin < 8 g/dL (OR = 3.8; 95% CI 1.4–10.5), AST 2.5 times increased from the limit of normal, and acute renal failure [82,83,84]. Another factor that was found to be associated with poor outcomes was the presence of multiple infections [37,85]. In contrast, ART was found to be a protective factor for severe disease and mortality [72,83]. Treatment relapse was associated with nonadherence to antifungal treatment, central nervous system (CNS) histoplasmosis, and Histoplasma antigenuria above 2.0 ng/mL at 1-year follow-up [86].

6. Conclusions and Future Perspectives

In recent years, the concept of histoplasmosis as a disease geographically limited to the Americas has been changing, and due to the development of novel diagnostics assays, and increasing disease awareness, a new concept of histoplasmosis as a global disease is becoming more popular [42,45,87,88,89]. Currently, most histoplasmosis cases are reported from the American continent, where it was estimated that in PLHIV with advanced disease, up to 15,600 new cases and 4500 deaths occurred in 2012 [26]. In some countries in Latin America, disease burden estimates are becoming more accurate, likely resulting from the implementation of strategies for improved detection of histoplasmosis in PLHIV [51,53,54,70,74]. Nevertheless, mortality associated with histoplasmosis remains high due to delayed diagnosis of histoplasmosis. Delayed diagnosis may be due to low clinical suspicion of histoplasmosis and limited access to testing [90,91,92].
The availability of rapid testing for histoplasmosis is still limited. Recent publications indicated that Histoplasma Ag detection testing and PCR testing were available in approximately 65% of Latin American countries and territories. Common characteristics of laboratories that reported performing histoplasmosis Ag/PCR testing included being specialized and located in major cities [93,94]. Our review indicates that the availability of novel commercial tests for detection of Histoplasma Ag detection is having a beneficial effect on case detection and reduction of mortality [44,51,54,70,74,95,96].
Aided by other initiatives, such as the publication of the first WHO global guidelines for the diagnosis and treatment of histoplasmosis in PLHIV, the burden of histoplasmosis and associated mortality may be reduced further. To achieve this, additional investment in laboratory capacity and expertise in fungal diagnosis and clinical management will be needed. The development of more rapid diagnostic testing that can be performed at ‘bed-side’ will provide a quicker diagnosis and initiation of treatment. It is, therefore, essential to have greater access to effective antifungal drugs, such as liposomal amphotericin B and itraconazole oral solution. Current clinical management recommendations are supported by evidence from clinical trials that were conducted in the 1990s and early 2000s. New clinical trials are needed that evaluate shorter courses of antifungal treatment, investigate the efficacy of new generation antifungals, and determine management strategies for patients who suffer from co-infections, especially TB. For PLHIV, these and future advancements in the diagnosis and treatment of histoplasmosis should further result in reduction of mortality and enhanced quality of life.

Author Contributions

Conceptualization, D.H.C., J.F.M. and P.E.V.; methodology, D.H.C., J.F.M. and P.E.V.; formal analysis, D.H.C.; investigation, D.H.C., J.F.M. and P.E.V.; writing—original draft preparation, D.H.C., J.F.M. and P.E.V.; writing—review and editing, D.H.C., B.L.G., Á.M.T., Á.R., T.C., M.D.L., J.F.M. and P.E.V.; supervision, B.L.G., Á.M.T., Á.R., T.C., M.D.L., J.F.M. and P.E.V. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Acknowledgments

Diego H. Caceres also wants to thank the Corporación para Investigaciones Biológicas (CIB), the Mycotic Diseases Branch at the US Centers for Disease Control and Prevention (CDC), and the Center of Expertise in Mycology Radboudumc/CWZ.

Conflicts of Interest

The authors declare no conflict of interest. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC or the US Public Health Service.

References

  1. Van Dyke, M.C.C.; Teixeira, M.M.; Barker, B.M. Fantastic yeasts and where to find them: The hidden diversity of dimorphic fungal pathogens. Curr. Opin. Microbiol. 2019, 52, 55–63. [Google Scholar] [CrossRef] [PubMed]
  2. Lockhart, S.R.; Toda, M.; Benedict, K.; Caceres, D.H.; Litvintseva, A.P. Endemic and Other Dimorphic Mycoses in The Americas. J. Fungi 2021, 7, 151. [Google Scholar] [CrossRef] [PubMed]
  3. Kasuga, T.; White, T.J.; Koenig, G.; McEwen, J.; Restrepo, A.; Castañeda, E.; Da Silva Lacaz, C.; Heins-Vaccari, E.M.; De Freitas, R.S.; Zancopé-Oliveira, R.M.; et al. Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol. Ecol. 2003, 12, 3383–3401. [Google Scholar] [CrossRef] [PubMed]
  4. Sepúlveda, V.E.; Márquez, R.; Turissini, D.A.; Goldman, W.E.; Matute, D.R. Genome Sequences Reveal Cryptic Speciation in the Human Pathogen Histoplasma capsulatum. mBio 2017, 8, e01339-17. [Google Scholar] [CrossRef]
  5. Turland, N.J.; Wiersema, J.H.; Barrie, F.R.; Greuter, W.; Hawksworth, D.L.; Herendeen, P.S.; Knapp, S.; Kusber, W.H.; Li, D.Z.; Marhold, K.; et al. International Code of Nomenclature for Algae, Fungi, and Plants (Shenzhen Code) Adopted by the Nineteenth International Botanical Congress Shenzhen, China, July 2017; Regnum Vegetabile 159; Koeltz Botanical Books: Glashütten, Germany, 2018. [Google Scholar]
  6. Deepe, G.S., Jr.; Dolin, R.; Blaser, M.J. 265—Histoplasma capsulatum (Histoplasmosis) A2—Bennett, John, E. In Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th ed.; Elsevier: Amsterdam, The Netherlands, 2015; pp. 2949–2962.e1. [Google Scholar]
  7. de Perio, M.A.; Benedict, K.; Williams, S.L.; Niemeier-Walsh, C.; Green, B.J.; Coffey, C.; Di Giuseppe, M.; Toda, M.; Park, J.H.; Bailey, R.L.; et al. Occupational Histoplasmosis: Epidemiology and Prevention Measures. J. Fungi 2021, 7, 510. [Google Scholar] [CrossRef]
  8. Nel, J.S.; Bartelt, L.A.; van Duin, D.; Lachiewicz, A.M. Endemic Mycoses in Solid Organ Transplant Recipients. Infect. Dis. Clin. N. Am. 2018, 32, 667–685. [Google Scholar] [CrossRef]
  9. Singh, N.; Huprikar, S.; Burdette, S.D.; Morris, M.I.; Blair, J.E.; Wheat, L.J. Donor-derived fungal infections in organ transplant recipients: Guidelines of the American Society of Transplantation, infectious diseases community of practice. Am. J. Transpl. 2012, 12, 2414–2428. [Google Scholar] [CrossRef]
  10. Goodwin, R.A., Jr.; Des Prez, R.M. Pathogenesis and clinical spectrum of histoplasmosis. South Med. J. 1973, 66, 13–25. [Google Scholar] [CrossRef]
  11. Goodwin, R.A.; Loyd, J.E.; Des Prez, R.M. Histoplasmosis in normal hosts. Medicine 1981, 60, 231–266. [Google Scholar] [CrossRef]
  12. Darling, S.T. The Morphology of The Parasite (Histoplasma capsulatum) and the Lesions of Histoplasmosis, a Fatal Disease of Tropical America. J. Exp. Med. 1909, 11, 515–531. [Google Scholar] [CrossRef]
  13. Darling, S.T. A Protozoön General Infection Producing Pseudotubercles in the Lungs and Focal Necroses in the Liver, Spleen and Lymphnodes. J. Am. Med. Assoc. 1906, XLVI, 1283–1285. [Google Scholar] [CrossRef]
  14. Daniel, T.M.; Baum, G.L. Drama and Discovery: The Story of Histoplasmosis; Contributions in Medical Studies, no. 48; Greenwood Press: Westport, CT, USA, 2002; pp. 1–174. [Google Scholar]
  15. Baum, G.L.; Schwarz, J. The history of histoplasmosis, 1906 to 1956. N. Engl. J. Med. 1957, 256, 253–258. [Google Scholar] [CrossRef] [PubMed]
  16. Winckel, W.E.; Collier, W.A.; Treurniet, A.E. Contributions to the geographical pathology of Surinam. First case of generalized histoplasmosis in Surinam. Doc. Med. Geogr. Trop. 1952, 4, 218–222. [Google Scholar] [PubMed]
  17. Collier, W.A.; Winckel, W.E. Geographic pathology of Surinam. VI. Histoplasmosis in mammals of Surinam. Antonie Leeuwenhoek 1952, 18, 249–256. [Google Scholar] [PubMed]
  18. Wildervanck, A.; Collier, W.A.; Winckel, W.E. Two cases of histoplasmosis on farms near Paramaribo, Surinam; investigations into the epidemiology of the disease. Doc. Med. Geogr. Trop. 1953, 5, 108–115. [Google Scholar] [PubMed]
  19. Wiersema, J.P. A case of histoplasmosis in Surinam. Trop. Geogr. Med. 1963, 15, 356–360. [Google Scholar] [PubMed]
  20. Walig, C. Histoplasmin testing in a group of Dutch soldiers returning from Surinam. Ned. Milit. Geneeskd. Tijdschr. 1965, 18, 165–167. [Google Scholar]
  21. Gans, J.C.; Karbaat, J. Histoplasmosis in Dutch servicemen returning from Surinam. Trop. Geogr. Med. 1967, 19, 177–186. [Google Scholar]
  22. Kaufman, L.; Huppert, M.; Fava Netto, C.; Pollak, L.; Restrepo, A. Manual of Standardized Serodiagnostic Procedures for Systemic Mycoses: Complement Fixation Tests; Pan American Health Organization: Washington, DC, USA, 1974. [Google Scholar]
  23. Bialek, R.; Feucht, A.; Aepinus, C.; Just-Nübling, G.; Robertson, V.J.; Knobloch, J.; Hohle, R. Evaluation of two nested PCR assays for detection of Histoplasma capsulatum DNA in human tissue. J. Clin. Microbiol. 2002, 40, 1644–1647. [Google Scholar] [CrossRef]
  24. Bialek, R.; Ernst, F.; Dietz, K.; Najvar, L.K.; Knobloch, J.; Graybill, J.R.; Schaumburg-Lever, G. Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections. Am. J. Clin. Pathol. 2002, 117, 597–603. [Google Scholar] [CrossRef]
  25. Queiroz-Telles, F.; Fahal, A.H.; Falci, D.R.; Caceres, D.H.; Chiller, T.; Pasqualotto, A.C. Neglected endemic mycoses. Lancet Infect. Dis. 2017, 17, e367–e377. [Google Scholar] [CrossRef] [PubMed]
  26. Adenis, A.A.; Valdes, A.; Cropet, C.; McCotter, O.Z.; Derado, G.; Couppie, P.; Chiller, T.; Nacher, M. Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: A modelling study. Lancet Infect Dis. 2018, 18, 1150–1159. [Google Scholar] [CrossRef] [PubMed]
  27. Ashraf, N.; Kubat, R.C.; Poplin, V.; Adenis, A.A.; Denning, D.W.; Wright, L.; McCotter, O.; Schwartz, I.S.; Jackson, B.R.; Chiller, T.; et al. Re-drawing the Maps for Endemic Mycoses. Mycopathologia 2020, 185, 843–865. [Google Scholar] [CrossRef] [PubMed]
  28. Kauffman, C.A. Diagnosis of histoplasmosis in immunosuppressed patients. Curr. Opin. Infect. Dis. 2008, 21, 421–425. [Google Scholar] [CrossRef]
  29. Hage, C.A.; Azar, M.M.; Bahr, N.; Loyd, J.; Wheat, L.J. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Semin. Respir. Crit. Care Med. 2015, 36, 729–745. [Google Scholar] [CrossRef]
  30. Joore, J.C.; Marcelis, J.H.; Sie-Go, D.M.; Borleffs, J.C.; Hoepelman, I.M. Histoplasma capsulatum infection, a manifestation of AIDS unusual for The Netherlands. Ned. Tijdschr. Geneeskd. 1990, 134, 1908–1910. [Google Scholar]
  31. CDC. AIDS and Opportunistic Infections. Available online: https://www.cdc.gov/hiv/basics/livingwithhiv/opportunisticinfections.html (accessed on 20 May 2021).
  32. WHO. Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy. Available online: https://www.who.int/hiv/pub/guidelines/advanced-HIV-disease/en/ (accessed on 1 July 2017).
  33. Dodge, H.J.; Payne, M.W.; Whitehouse, W.M.; Bauman, K.A. Estimates of the prevalence of tuberculous and histoplasmal infections in a sample of the population of Tecumseh, Michigan, 1960. Am. Rev. Respir. Dis. 1965, 92, 459–469. [Google Scholar]
  34. Adenis, A.; Nacher, M.; Hanf, M.; Basurko, C.; Dufour, J.; Huber, F.; Aznar, C.; Carme, B.; Couppie, P. Tuberculosis and histoplasmosis among human immunodeficiency virus-infected patients: A comparative study. Am. J. Trop. Med. Hyg. 2014, 90, 216–223. [Google Scholar] [CrossRef]
  35. Caceres, D.H.; Valdes, A. Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV. J. Fungi 2019, 5, 73; [Google Scholar] [CrossRef]
  36. Medina, N.; Alastruey-Izquierdo, A.; Mercado, D.; Bonilla, O.; Pérez, J.C.; Aguirre, L.; Samayoa, B.; Arathoon, E.; Denning, D.W.; Rodriguez-Tudela, J.L. Comparative performance of the laboratory assays used by a Diagnostic Laboratory Hub for opportunistic infections in people living with HIV. AIDS 2020, 34, 1625–1632. [Google Scholar] [CrossRef]
  37. Samayoa, B.; Roy, M.; Cleveland, A.A.; Medina, N.; Lau-Bonilla, D.; Scheel, C.M.; Gomez, B.L.; Chiller, T.; Arathoon, E. High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala. Am. J. Trop. Med. Hyg. 2017, 97, 42–48. [Google Scholar] [CrossRef] [PubMed]
  38. Caceres, D.H.; Tobón, Á.M.; Restrepo, Á.; Chiller, T.; Gómez, B.L. The important role of co-infections in patients with AIDS and progressive disseminated histoplasmosis (PDH): A cohort from Colombia. Med. Mycol. Case Rep. 2018, 19, 41–44. [Google Scholar] [CrossRef] [PubMed]
  39. Nacher, M.; Leitao, T.S.; Gomez, B.L.; Couppie, P.; Adenis, A.; Damasceno, L.; Demar, M.; Samayoa, B.; Caceres, D.H.; Pradinaud, R.; et al. The Fight against HIV-Associated Disseminated Histoplasmosis in the Americas: Unfolding the Different Stories of Four Centers. J. Fungi 2019, 5, 51. [Google Scholar] [CrossRef] [PubMed]
  40. Cáceres, D.H.; Gómez, B.L.; Restrepo, Á.; Tobón, Á.M. Histoplasmosis y sida: Factores de riesgo clínicos y de laboratorio asociados al pronóstico de la enfermedad. Infection 2012, 16, 44–50. [Google Scholar] [CrossRef]
  41. Samayoa, B.; Aguirre, L.; Bonilla, O.; Medina, N.; Lau-Bonilla, D.; Mercado, D.; Moller, A.; Perez, J.C.; Alastruey-Izquierdo, A.; Arathoon, E.; et al. The Diagnostic Laboratory Hub: A New Health Care System Reveals the Incidence and Mortality of Tuberculosis, Histoplasmosis, and Cryptococcosis of PWH in Guatemala. Open Forum Infect. Dis. 2020, 7, ofz534. [Google Scholar] [CrossRef] [PubMed]
  42. PAHO/WHO. Guidelines for Diagnosing and Managing Disseminated Histoplasmosis among People Living with HIV. Available online: https://iris.paho.org/bitstream/handle/10665.2/52304/9789275122495_eng.pdf?sequence=1&isAllowed=y (accessed on 1 April 2020).
  43. Caceres, D.H.; Gomez, B.L.; Tobon, A.M.; Chiller, T.M.; Lindsley, M.D. Evaluation of a Histoplasma antigen Lateral Flow Assay for the rapid diagnosis of progressive disseminated histoplasmosis in Colombian patients with AIDS. Mycoses 2019, 63, 139–144. [Google Scholar] [CrossRef] [PubMed]
  44. Caceres, D.H.; Samayoa, B.E.; Medina, N.G.; Tobon, A.M.; Guzman, B.J.; Mercado, D.; Restrepo, A.; Chiller, T.; Arathoon, E.E.; Gomez, B.L. Multicenter Validation of Commercial Antigenuria Reagents to Diagnose Progressive Disseminated Histoplasmosis in People Living with HIV/AIDS in Two Latin American Countries. J. Clin. Microbiol. 2018, 56, e01959-17. [Google Scholar] [CrossRef]
  45. World Health Organization (WHO). Second WHO Model List of Essential In Vitro Diagnostics. Available online: https://www.who.int/medical_devices/publications/Standalone_document_v8.pdf?ua=1 (accessed on 20 November 2019).
  46. World Health Organization (WHO) fungal priority pathogens list to guide research, development and public health action. 2022. Available online: https://www.who.int/publications/i/item/9789240060241 (accessed on 25 October 2022).
  47. Caceres, D.H.; Knuth, M.; Derado, G.; Lindsley, M.D. Diagnosis of Progressive Disseminated Histoplasmosis in Advanced HIV: A Meta-Analysis of Assay Analytical Performance. J. Fungi 2019, 5, 76. [Google Scholar] [CrossRef]
  48. Blan, B.D.S.; Poester, V.R.; Basso, R.P.; Benelli, J.L.; Sanchotene, K.O.; Caceres, D.H.; Doherty, B.; Pasqualotto, A.C.; Xavier, M.O. Optimization of a commercial Histoplasma galactomannan EIA test in a population from an endemic area of histoplasmosis in southern Brazil. Mycoses 2023, 66, 304–307. [Google Scholar] [CrossRef]
  49. Donnelly, J.P.; Chen, S.C.; Kauffman, C.A.; Steinbach, W.J.; Baddley, J.W.; Verweij, P.E.; Clancy, C.J.; Wingard, J.R.; Lockhart, S.R.; Groll, A.H.; et al. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin. Infect. Dis. 2020, 71, 1367–1376. [Google Scholar] [CrossRef]
  50. Scheel, C.M.; Samayoa, B.; Herrera, A.; Lindsley, M.D.; Benjamin, L.; Reed, Y.; Hart, J.; Lima, S.; Rivera, B.E.; Raxcaco, G.; et al. Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients. Clin. Vaccine Immunol. 2009, 6, 852–858. [Google Scholar] [CrossRef] [PubMed]
  51. Medina, N.; Rodriguez-Tudela, J.L.; Aguirre, L.; Salazar, L.R.; Gamboa, O.; Bonilla, O.; Pérez, J.C.; Arathoon, E.; Denning, D.W.; Alastruey-Izquierdo, A. Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality. Microorganisms 2021, 9, 596. [Google Scholar] [CrossRef] [PubMed]
  52. Gutierrez, M.E.; Canton, A.; Sosa, N.; Puga, E.; Talavera, L. Disseminated histoplasmosis in patients with AIDS in Panama: A review of 104 cases. Clin. Infect. Dis. 2005, 40, 1199–1202. [Google Scholar] [CrossRef]
  53. Forno, D.; Samayoa, B.; Medina, N.; Arathoon, E.; Mejia, C.R.; Gordillo, R.; Cedillos, R.; Rodas, J.; Ahlquist Cleveland, A.; Chiller, T.; et al. Diagnosis of fungal opportunistic infections in people living with HIV from Guatemala and El Salvador. Mycoses 2021, 64, 1563–1570. [Google Scholar] [CrossRef]
  54. Caceres, D.H.; Arauz, A.B.; Flores, C.; Santiago, E.; Montoya, S.; Saenz, C.; Torres-Meneses, F.A.; Peralta, H.; Zuniga-Moya, J.C.; Lainez Arteaga, I.Z.; et al. Implementation of rapid diagnostics assays for detection of histoplasmosis and cryptococcosis in central american people living with HIV. Mycoses 2021, 64, 1396–1401. [Google Scholar] [CrossRef] [PubMed]
  55. López Daneri, A.G.; Arechavala, A.; Iovannitti, C.A.; Mujica, M.T. Histoplasmosis diseminada en pacientes HIV/SIDA: Buenos Aires, 2009-2014. Medicina 2016, 76, 332–337. [Google Scholar]
  56. Messina, F.A.; Corti, M.; Negroni, R.; Arechavala, A.; Bianchi, M.; Santiso, G. Histoplasmosis in AIDS patients without tegumentary manifestations. Rev. Chil. Infectol. 2018, 35, 560–565. [Google Scholar] [CrossRef] [PubMed]
  57. Francini, B.; Cánepa, M.C.; Lamonica, C.; Capece, P.; Posse, G.; Sanguineri, V.; Sanzo, A.B.D.; Berton, C.; Martinelli, N.; Posada, O.; et al. Disseminated histoplasmosis. An oportunistic infection in HIV positive patients Experience in the Hospital Nacional Prof. A. Posadas, 2011–2017. Rev. Chil. Infectol. 2018, 35, 671–679. [Google Scholar] [CrossRef] [PubMed]
  58. Boigues, B.C.S.; Paniago, A.M.M.; Lima, G.M.E.; Nunes, M.O.; Uehara, S.N.O. Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high-complexity hospital in Campo Grande, MS, Brazil. Rev. Soc. Bras. Med. Trop. 2018, 51, 155–161. [Google Scholar] [CrossRef] [PubMed]
  59. Daher, E.F.; Silva, G.B., Jr.; Barros, F.A.; Takeda, C.F.; Mota, R.M.; Ferreira, M.T.; Oliveira, S.A.; Martins, J.C.; Araújo, S.M.; Gutiérrez-Adrianzén, O.A. Clinical and laboratory features of disseminated histoplasmosis in HIV patients from Brazil. Trop. Med. Int. Health 2007, 12, 1108–1115. [Google Scholar] [CrossRef] [PubMed]
  60. Brilhante, R.S.; Fechine, M.A.; Mesquita, J.R.; Cordeiro, R.A.; Rocha, M.F.; Monteiro, A.J.; Lima, R.A.; Caetano É, P.; Pereira, J.F.; Castelo-Branco, D.S.; et al. Histoplasmosis in HIV-positive patients in Ceará, Brazil: Clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates. Trans. R. Soc. Trop. Med. Hyg. 2012, 106, 484–488. [Google Scholar] [CrossRef] [PubMed]
  61. Leitão, T.; Oliveira Filho, A.M.P.; Sousa Filho, J.E.P.; Tavares, B.M.; Mesquita, J.R.L.; Farias, L.; Mota, R.S.; Nacher, M.; Damasceno, L.S. Accuracy of Buffy Coat in the Diagnosis of Disseminated Histoplasmosis in AIDS-Patients in an Endemic Area of Brazil. J. Fungi 2019, 5, 47. [Google Scholar] [CrossRef] [PubMed]
  62. da Silva Ferreira, B.; de Araujo Filho, J.A.; Matos Pereira, N.; de Miranda Godoy, L.; Borges Lamounier, B.; Dias Nunes, E.; Espindola Rosa, L. Disseminated histoplasmosis in AIDS patients: An urban disease. Experience in a metropolis in the middle east of Brasil. Infez. Med. 2017, 25, 258–262. [Google Scholar] [PubMed]
  63. Rakislova, N.; Hurtado, J.C.; Palhares, A.E.M.; Ferreira, L.; Freire, M.; Lacerda, M.; Monteiro, W.; Navarro, M.; Casas, I.; Teixeira, M.M.; et al. High prevalence and mortality due to Histoplasma capsulatum in the Brazilian Amazon: An autopsy study. PLoS Negl. Trop. Dis. 2021, 15, e0009286. [Google Scholar] [CrossRef]
  64. Chang, M.R.; Taira, C.L.; Paniago, A.M.; Taira, D.L.; Cunha, R.V.; Wanke, B. Study of 30 cases of histoplasmosis observed in the Mato Grosso do Sul State, Brazil. Rev. Inst. Med. Trop. Sao Paulo 2007, 49, 37–39. [Google Scholar] [CrossRef]
  65. de Oliveira, R.B.; Atobe, J.H.; Souza, S.A.; de Castro Lima Santos, D.W. Epidemiology of invasive fungal infections in patients with acquired immunodeficiency syndrome at a reference hospital for infectious diseases in Brazil. Mycopathologia 2014, 178, 71–78. [Google Scholar] [CrossRef]
  66. Casotti, J.A.; Motta, T.Q.; Ferreira, C.U., Jr.; Cerutti, C., Jr. Disseminated histoplasmosis in HIV positive patients in Espírito Santo state, Brazil: A clinical-laboratory study of 12 cases (1999–2001). Braz. J. Infect. Dis. 2006, 10, 327–330. [Google Scholar] [CrossRef]
  67. Mora, D.J.; dos Santos, C.T.; Silva-Vergara, M.L. Disseminated histoplasmosis in acquired immunodeficiency syndrome patients in Uberaba, MG, Brazil. Mycoses 2008, 51, 136–140. [Google Scholar] [CrossRef]
  68. Hoffmann, E.R.; Daboit, T.C.; Paskulin, D.D.; Monteiro, A.A.; Falci, D.R.; Linhares, T.; Flores, J.M.; Goldani, L.Z.; de Melo, M.G.; Behar, P.R.; et al. Disseminated histoplasmosis and AIDS: A prospective and multicentre study to evaluate the performance of different diagnostic tests. Mycoses 2017, 60, 20–24. [Google Scholar] [CrossRef]
  69. Basso, R.P.; Poester, V.R.; Benelli, J.L.; Stevens, D.A.; Xavier, M.O. Disseminated Histoplasmosis in Persons with HIV/AIDS, Southern Brazil, 2010-2019. Emerg. Infect. Dis. 2022, 28, 721–724. [Google Scholar] [CrossRef]
  70. Falci, D.R.; Monteiro, A.A.; Braz Caurio, C.F.; Magalhaes, T.C.O.; Xavier, M.O.; Basso, R.P.; Melo, M.; Schwarzbold, A.V.; Ferreira, P.R.A.; Vidal, J.E.; et al. Histoplasmosis, An Underdiagnosed Disease Affecting People Living With HIV/AIDS in Brazil: Results of a Multicenter Prospective Cohort Study Using Both Classical Mycology Tests and Histoplasma Urine Antigen Detection. Open Forum Infect. Dis. 2019, 6, ofz073. [Google Scholar] [CrossRef] [PubMed]
  71. Arango, M.; Castañeda, E.; Agudelo, C.I.; De Bedout, C.; Agudelo, C.A.; Tobón, A.; Linares, M.; Valencia, Y.; Restrepo, A. Histoplasmosis: Results of the Colombian national survey, 1992-2008. Biomedica 2011, 31, 344–356. [Google Scholar] [CrossRef] [PubMed]
  72. Tobón, A.M.; Agudelo, C.A.; Rosero, D.S.; Ochoa, J.E.; De Bedout, C.; Zuluaga, A.; Arango, M.; Cano, L.E.; Sampedro, J.; Restrepo, A. Disseminated histoplasmosis: A comparative study between patients with acquired immunodeficiency syndrome and non-human immunodeficiency virus-infected individuals. Am. J. Trop. Med. Hyg. 2005, 73, 576–582. [Google Scholar] [CrossRef] [PubMed]
  73. Caceres, D.H.; Tobon, A.M.; Cleveland, A.A.; Scheel, C.M.; Berbesi, D.Y.; Ochoa, J.; Restrepo, A.; Brandt, M.E.; Chiller, T.; Gomez, B.L. Clinical and Laboratory Profile of Persons Living with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Histoplasmosis from a Colombian Hospital. Am. J. Trop. Med. Hyg. 2016, 95, 918–924. [Google Scholar] [CrossRef]
  74. Caceres, D.H.; Zuluaga, A.; Arango-Bustamante, K.; de Bedout, C.; Tobón Á, M.; Restrepo, Á.; Gómez, B.L.; Cano, L.E.; González, Á. Implementation of a Training Course Increased the Diagnosis of Histoplasmosis in Colombia. Am. J. Trop. Med. Hyg. 2015, 93, 662–667. [Google Scholar] [CrossRef]
  75. Hoyos Pulgarin, J.A.; Alzate Piedrahita, J.A.; Moreno Gómez, G.A.; Sierra Palacio, J.F.; Ordoñez, K.M.; Arias Ramos, D. Closing gaps in histoplasmosis: Clinical characteristics and factors associated with probable/histoplasmosis in HIV/AIDS hospitalized patients, a retrospective cross-sectional study in two tertiary centers in Pereira, Colombia. AIDS Res. Ther. 2021, 18, 51. [Google Scholar] [CrossRef]
  76. Nacher, M.; Valdes, A.; Adenis, A.; Blaizot, R.; Abboud, P.; Demar, M.; Djossou, F.; Epelboin, L.; Misslin, C.; Ntab, B.; et al. Disseminated Histoplasmosis in HIV-Infected Patients: A Description of 34 Years of Clinical and Therapeutic Practice. J. Fungi 2020, 6, 164. [Google Scholar] [CrossRef]
  77. Vantilcke, V.; Boukhari, R.; Jolivet, A.; Vautrin, C.; Misslin, C.; Adenis, A.; Nacher, M. Fever in hospitalized HIV-infected patients in Western French Guiana: First think histoplasmosis. Int. J. STD AIDS 2014, 25, 656–661. [Google Scholar] [CrossRef]
  78. Cachera, L.; Adenis, A.; Guarmit, B.; Rabier, S.; Couppié, P.; Djossou, F.; Epelboin, L.; Melzani, A.; Abboud, P.; Blanchet, D.; et al. Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009–2019. J. Fungi 2021, 7, 421. [Google Scholar] [CrossRef]
  79. Perez-Lazo, G.; Maquera-Afaray, J.; Mejia, C.R.; Castillo, R. Disseminated histoplasmosis and HIV infection: Case series in a Peruvian hospital. Rev. Chil. Infectología 2017, 34, 365–369. [Google Scholar] [CrossRef]
  80. Chincha, O.; Bustamante, B. Current status of progressive disseminated histoplasmosis in HIV infected patients in a third level hospital in Peru. Rev. Iberoam. Micol. 2022, 39, 25–27. [Google Scholar] [CrossRef] [PubMed]
  81. Vidal, J.E.; Werlang, P.C.; Muniz, B.M.; Rego, C.M.; Barbalho, R.E.; Baptista, A.M.; Telles, J.P.; da Cruz, A.B.; Pereira, I.S.; Gava, R.; et al. Combining urine antigen and blood polymerase chain reaction for the diagnosis of disseminated histoplasmosis in hospitalized patients with advanced HIV disease. Med. Mycol. 2021, 59, 916–922. [Google Scholar] [CrossRef] [PubMed]
  82. Couppié, P.; Sobesky, M.; Aznar, C.; Bichat, S.; Clyti, E.; Bissuel, F.; El Guedj, M.; Alvarez, F.; Demar, M.; Louvel, D.; et al. Histoplasmosis and acquired immunodeficiency syndrome: A study of prognostic factors. Clin. Infect. Dis. 2004, 38, 134–138. [Google Scholar] [CrossRef] [PubMed]
  83. Wheat, L.J.; Chetchotisakd, P.; Williams, B.; Connolly, P.; Shutt, K.; Hajjeh, R. Factors associated with severe manifestations of histoplasmosis in AIDS. Clin. Infect. Dis. 2000, 30, 877–881. [Google Scholar] [CrossRef] [PubMed]
  84. de Francesco Daher, E.; de Sousa Barros, F.A.; da Silva Júnior, G.B.; Takeda, C.F.; Mota, R.M.; Ferreira, M.T.; Martins, J.C.; Oliveira, S.A.; Gutiérrez-Adrianzén, O.A. Risk factors for death in acquired immunodeficiency syndrome-associated disseminated histoplasmosis. Am. J. Trop. Med. Hyg. 2006, 74, 600–603. [Google Scholar] [CrossRef]
  85. Medina, N.; Alastruey-Izquierdo, A.; Bonilla, O.; Gamboa, O.; Mercado, D.; Pérez, J.C.; Salazar, L.R.; Arathoon, E.; Denning, D.W.; Rodriguez-Tudela, J.L. A Rapid Screening Program for Histoplasmosis, Tuberculosis, and Cryptococcosis Reduces Mortality in HIV Patients from Guatemala. J. Fungi 2021, 7, 268. [Google Scholar] [CrossRef]
  86. Myint, T.; Anderson, A.M.; Sanchez, A.; Farabi, A.; Hage, C.; Baddley, J.W.; Jhaveri, M.; Greenberg, R.N.; Bamberger, D.M.; Rodgers, M.; et al. Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): Multicenter study of outcomes and factors associated with relapse. Medicine 2014, 93, 11–18. [Google Scholar] [CrossRef]
  87. Nacher, M.; Adenis, A.; Arathoon, E.; Samayoa, B.; Lau-Bonilla, D.; Gomez, B.L.; Tobon, A.; Caceres, D.H.; Marques da Silva, S.; Mesquita da Costa, M.; et al. Disseminated histoplasmosis in Central and South America, the invisible elephant: The lethal blind spot of international health organizations. AIDS 2016, 30, 167–170. [Google Scholar] [CrossRef]
  88. World Health Organization (WHO). WHO Model List of Essential Medicines. Available online: https://apps.who.int/iris/bitstream/handle/10665/325771/WHO-MVP-EMP-IAU-2019.06-eng.pdf?ua=1 (accessed on 30 September 2021).
  89. Bahr, N.C.; Antinori, S.; Wheat, L.J.; Sarosi, G.A. Histoplasmosis infections worldwide: Thinking outside of the Ohio River valley. Curr. Trop. Med. Rep. 2015, 2, 70–80. [Google Scholar] [CrossRef]
  90. Benedict, K.; Li, Y.; Molinari, N.A.M.; Jackson, B.R. Health Care Providers’ Testing Practices for Coccidioidomycosis and Histoplasmosis in Patients With Community-Acquired Pneumonia-United States, 2020. Open Forum Infect. Dis. 2021, 8, ofab020. [Google Scholar] [CrossRef]
  91. Benedict, K.; Kobayashi, M.; Garg, S.; Chiller, T.; Jackson, B.R. Symptoms in blastomycosis, coccidioidomycosis, and histoplasmosis versus other respiratory illnesses in commercially insured adult outpatients, United States, 2016–2017. Clin. Infect. Dis. 2021, 73, e4336–e4344. [Google Scholar] [CrossRef] [PubMed]
  92. Benedict, K.; Molinari, N.A.M.; Jackson, B.R. Public Awareness of Invasive Fungal Diseases—United States, 2019. MMWR Morb. Mortal. Wkly. Rep. 2020, 69, 1343–1346. [Google Scholar] [CrossRef] [PubMed]
  93. Caceres, D.H.; Adenis, A.; de Souza, J.V.B.; Gomez, B.L.; Cruz, K.S.; Pasqualotto, A.C.; Ravasi, G.; Perez, F.; Chiller, T.; de Lacerda, M.V.G.; et al. The Manaus Declaration: Current Situation of Histoplasmosis in the Americas, Report of the II Regional Meeting of the International Histoplasmosis Advocacy Group. journal article. Curr. Fungal Infect. Rep. 2019, 13, 244–249. [Google Scholar] [CrossRef]
  94. Caceres, D.H.; Echeverri Tirado, L.C.; Bonifaz, A.; Adenis, A.; Gomez, B.L.; Flores, C.L.B.; Canteros, C.E.; Santos, D.W.; Arathoon, E.; Soto, E.R.; et al. Current situation of endemic mycosis in the Americas and the Caribbean: Proceedings of the first international meeting on endemic mycoses of the Americas (IMEMA). Mycoses 2022, 65, 1179–1187. [Google Scholar] [CrossRef]
  95. Cáceres, D.H.; Gómez, B.L.; Tobón, Á.M.; Minderman, M.; Bridges, N.; Chiller, T.; Lindsley, M.D. Validation and Concordance Analysis of a New Lateral Flow Assay for Detection of Histoplasma Antigen in Urine. J. Fungi 2021, 7, 799. [Google Scholar] [CrossRef]
  96. Martínez-Gamboa, A.; Niembro-Ortega, M.D.; Torres-González, P.; Santiago-Cruz, J.; Velázquez-Zavala, N.G.; Rangel-Cordero, A.; Crabtree-Ramírez, B.; Gamboa-Domínguez, A.; Reyes-Gutiérrez, E.; Reyes-Terán, G.; et al. Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico. PLoS Negl. Trop. Dis. 2021, 15, e0009215. [Google Scholar] [CrossRef]
Table
Table 1. Summary of meta-analysis for the analytical performance of assays for the diagnosis of histoplasmosis in PLHIV.
Table 1. Summary of meta-analysis for the analytical performance of assays for the diagnosis of histoplasmosis in PLHIV.
AssaySensitivity %
(95% CI)		Specificity %
(95% CI)		Accuracy %
(95% CI)
Culture77 (72–81)NDND
Antibody detection assays58 (53–62)100 (99–100)89 (87–91)
Antigen detection assays95 (94–97)97 (97–98)95 (94–96)
Molecular assays95 (89–100)99 (96–100)96 (94–99)
(95%CI) 95% confidence interval. Adapted from reference [47].
Table
Table 2. Analysis of case series of histoplasmosis associated with HIV in Latin America.
Table 2. Analysis of case series of histoplasmosis associated with HIV in Latin America.
Location
(Reference)		PeriodStudy Type Study Population and Principal Findings
(%) Histoplasmosis Frequency		Co-Infections and TB Co-InfectionMortality
Central America
Guatemala, Guatemala City [50]2005–2007Prospective cohort studyNo48 histoplasmosis in 217 patients analyzed (22%)ND19/48 (40%)
Guatemala, Guatemala City [37]2005–2009Prospective cohort studyNo101 histoplasmosis in 263 patients analyzed (38%)30%
-
TB: 25%
44%
Guatemala
13 HIV clinics across Guatemala [51]		2017–2019Prospective cohort studyYes473 histoplasmosis in 6366 patients analyzed (7%)16%
-
TB: 57%
Mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 33% in 2017 to 21% in 2019.
Panama, Panama City [52]1997–2003RetrospectiveNo182 histoplasmosis in 2379 patients analyzed (8%) (104 included for study analysis)27/104 (26%)
-
TB: 16/27 (59%)
13/104 (13%)
Guatemala, Guatemala City
El Salvador, San Salvador [53]		2012–2014Multicenter laboratory surveillanceYes96 histoplasmosis44%
-
TB: 18%
Overall mortality: 18%
-
14% in diagnose by Ag testing
-
75% in non-diagnosed by Ag testing
-
Panama, Panama City
-
Honduras, Tegucigalpa, and San Pedro de Sula
-
Nicaragua, Managua [54]
2016–2018Multicenter laboratory surveillanceYes269 histoplasmosis in 1343 patients analyzed (20%)
-
Panama: 201/857 (23%)
-
Honduras: 34/106 (32%)
-
Nicaragua: 34/380 (9%)
NDND
South America
Argentina, Buenos Aires [55]2009–2014RetrospectiveNo171 histoplasmosis70/171 (41%)
-
TB: 20/70 (29%)
34/171 (20%)
Argentina, Buenos Aires [56]2010–2021RetrospectiveNo80 histoplasmosisND26%
Argentina, Buenos Aires [57]2011–2017RetrospectiveNo37 histoplasmosis14%15%
Brazil, Campo Grande [58]2011–2016RetrospectiveNo23 histoplasmosis
-
Pneumocystis and TB: 26%
-
Neuro-toxoplasmosis and bacterial pneumonia: 17%
-
Visceral leishmaniasis and cryptococcosis: 9%
-
Syphilis: 4%
57%
Brazil, Ceará State [59]1995–2004RetrospectiveNo164 histoplasmosis in 378 patients analyzed (43%)ND52/164 (32%)
-
Mortality on ART: 4%
-
Mortality on non-ART: 28%
Brazil, Ceará State [60]1999–2005RetrospectiveNo191 histoplasmosis
-
134 cases analyzed
ND44/134 (33%)
Brazil, Ceará State [61]2012–2013Cross-sectional studyNo489 buffy coats of 361 patients. Laboratory results:
-
First culture (proven cases): 61/361
-
Sequential culture: 22% sensitivity.
-
First buffy coat: 19/361
-
Sequential buffy coat: 32% sensitivity.
ND18%
Brazil, Ceará State [60]2006–2010RetrospectiveNo208 histoplasmosisND88/208 (42%)
Brazil, Goiânia [62]2003–2014RetrospectiveNo166 histoplasmosis in 2.285 patients analyzed (7%)ND88/166 (53%)
Brazil, Manaus [63]2014–2015Autopsy analysisNo14 HIV-Histoplasmosis in 37 HIV-patients analyzed (38%)8/14 (57%)8/37 (22%)
Brazil, Mato Grosso do Sul [64]1998–2005RetrospectiveNo30 histoplasmosis14/30 (47%)12/30 (40%)
Brazil, Sao Paulo [65]2001RetrospectiveNo12 histoplasmosis in 90 patients analyzed (13%)
(7.1 cases/1.000 hospitalizations per year)		ND33%
Brazil, Espírito Santo State [66]1999–2001RetrospectiveNo12 histoplasmosis in 571 patients analyzed (2%)ND2/12 (17%)
Brazil, Uberaba, MG [67]1992–2005RetrospectiveNo57 histoplasmosisND18/57 (32%)
Brazil, Porto Alegre [68]2014–2015Prospective cohort studyYes8 proven histoplasmosis by culture (10%)
13 probable by commercial Ag test (17%)
14 probable by in-house Ag test (18%) 		25% of TB co-infection in proven histoplasmosis cases25% in proven histoplasmosis cases
Brazil, Rio Grande [69]2010–2019RetrospectivePeriod 1: No
Period 2: Yes		Overall: 31 histoplasmosis
-
Period 1: 15 histoplasmosis
-
(8 cases per 1.000 hospitalizations)
-
Period 2: 16 histoplasmosis
-
(24 cases per 1.000 hospitalizations)
28/31 (90%)
-
TB: 9/28 (32%)
11/31 (35%)
Brazil
14 hospitals in the states of:
Rio Grande do Norte
Bahia
Goiás
Ceará
Rio Grande do Sul
Sao Paulo [70]		2016–2018Prospective cohort studyYes123 histoplasmosis in 570 patients analyzed (22%).
By state:
-
Rio Grande do Norte: 13/29 (45%)
-
Bahia: 4/9 (44%)
-
Goiás: 50/126 (40%)
-
Ceará: 23/62 (37%)
-
Rio Grande do Sul: 26/264 (10%)
-
Sao Paulo: 7/80 (9%)
Urinary antigen detection increased the diagnostic yield in 54%		Coinfection with:
-
CMV: n = 25 (20%)
-
TB: n = 19 (15%)
-
P. jirovecii: n = 14 (11%)
Overall, 30-day mortality was 22%
-
14% in patients with antigen-based diagnosis (6/42).
-
27% in patients with conventional-based diagnosis (21/78)
Colombia, 20 states [71]1992–2008Voluntary surveyNo280 histoplasmosisNDND
Colombia, Medellin [72]1979–2001RetrospectiveNo30 histoplasmosis21/30 (70%)7/30 (23%)
Colombia, Medellin [38,73]2008–2011Prospective cohort studyNo45 histoplasmosis in 45 patients analyzed (51%)23/45 (51%)
-
TB was the most common co-infection (16/23; 70%)
8/45 (18%)
Colombia, 17 states [74]2009–2012Prospective cohort studyYes105 histoplasmosis in 463 patients analyzed (23%). Implementation of a diagnostic program increased histoplasmosis detection.NDND
Colombia, Pereira [75]2014–2019RetrospectiveYes50 histoplasmosis in 172 patients analyzed (29%)34/50 (68%)
-
TB: 22/34 (65%)
14/50 (28%)
French Guiana
-
Cayenne
-
Kourou
-
Saint Laurent du Maroni [76]
1981–2014Retrospective, multicentric studyNo349 histoplasmosis137/349 (39%)
-
TB: 18/137 (13%)
Crude 144/349 (41%)
-
30-days: 50/349 (14%) Changes on 30-days mortality among time:
-
Before 1998: 18/47 (38%)
-
1999–2003: 17/100 (17%)
-
2004–2009: 10/111 (9%)
-
2010–2014: 5/91 (6%)
French Guiana, Saint Laurent du Maroni [77]2008–2010RetrospectiveNo24 histoplasmosis in 67 patients analyzed (36%)33%3/24 (13%)
French Guiana, Cayenne [78]2009–2018RetrospectiveNo133 histoplasmosis in 227 patients analyzed (59%)ND12%
Peru, Lima [79]1996–2014RetrospectiveNo27 histoplasmosis 23/27 (85%)
-
TB: 3/23 (13%)
6/27 (22%)
Peru, Lima [80]2000–2019RetrospectiveNo43 histoplasmosisTB: 5/43 (12%)7/43 (16%)
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Cáceres, D.H.; Gómez, B.L.; Tobón, Á.M.; Restrepo, Á.; Chiller, T.; Lindsley, M.D.; Meis, J.F.; Verweij, P.E. Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions. J. Fungi 2023, 9, 558. https://doi.org/10.3390/jof9050558

AMA Style

Cáceres DH, Gómez BL, Tobón ÁM, Restrepo Á, Chiller T, Lindsley MD, Meis JF, Verweij PE. Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions. Journal of Fungi. 2023; 9(5):558. https://doi.org/10.3390/jof9050558

Chicago/Turabian Style

Cáceres, Diego H., Beatriz L. Gómez, Ángela M. Tobón, Ángela Restrepo, Tom Chiller, Mark D. Lindsley, Jacques F. Meis, and Paul E. Verweij. 2023. "Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions" Journal of Fungi 9, no. 5: 558. https://doi.org/10.3390/jof9050558

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop