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Candida albicans and non-albicans Isolates from Bloodstream Have Different Capacities to Induce Neutrophil Extracellular Traps

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Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey 64460, Mexico
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Unidad Monterrey, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Vía del Conocimiento 201, Parque PIIT, Apodaca, Monterrey 66628, Mexico
*
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(2), 28; https://doi.org/10.3390/jof5020028
Received: 11 March 2019 / Revised: 27 March 2019 / Accepted: 28 March 2019 / Published: 1 April 2019
Neutrophils activated with pathogens or their products induce formation of extracellular traps (NETs), but if this constitutes a general response against all pathogenic species in a single genus or intrageneric differences exist remains unknown, yet this is of great importance for the establishment of effective treatments. To determine this, we analyzed neutrophil extracellular traps formation after the stimulation with bloodstream isolates from different Candida species (Candida albicans, C. tropicalis, C. parapsilosis, and C. glabrata), and found that each species has a different capacity to induce DNA extrusion, which is independent of their morphology (yeast or hyphae). We observed that phospholipase producer’s strains and their secretion products were able to induce NETs, a property not observed with phospholipase deficient strains, with exception of some Candida glabrata sensu stricto isolates, which showed no NETs induction although they did show phospholipase production. To further analyze this, we extended our study to include Candida glabrata cryptic species (C. bracarensis and C. nivariensis) and no extracellular traps formation was observed. Here, we contribute to the understanding of how neutrophils initiate NETs, and we found that certain strains may have a differential capacity to trigger these structures, which may explain the high mortality of some isolates. View Full-Text
Keywords: neutrophil extracellular traps; Candida albicans; Candida non-albicans; phospholipases neutrophil extracellular traps; Candida albicans; Candida non-albicans; phospholipases
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Campos-Garcia, L.; Jimenez-Valdes, R.J.; Hernandez-Bello, R.; Palma-Nicolas, J.; Gonzalez, G.M.; Sanchez-Gonzalez, A. Candida albicans and non-albicans Isolates from Bloodstream Have Different Capacities to Induce Neutrophil Extracellular Traps. J. Fungi 2019, 5, 28.

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