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Animal Models to Study Mucormycosis

1
Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), Beutenbergstrasse 11a, 07745 Jena, Germany
2
Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany
J. Fungi 2019, 5(2), 27; https://doi.org/10.3390/jof5020027
Received: 21 February 2019 / Revised: 22 March 2019 / Accepted: 26 March 2019 / Published: 27 March 2019
(This article belongs to the Special Issue Mucorales and Mucormycosis)
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PDF [286 KB, uploaded 27 March 2019]

Abstract

Mucormycosis is a rare but often fatal or debilitating infection caused by a diverse group of fungi. Animal models have been crucial in advancing our knowledge of mechanisms influencing the pathogenesis of mucormycoses, and to evaluate therapeutic strategies. This review describes the animal models established for mucormycosis, summarizes how they have been applied to study mucormycoses, and discusses the advantages and limitations of the different model systems. View Full-Text
Keywords: mucorales; mucormycosis; pathogenesis; infection models; mouse models; Galleria mellonella; Caenorhabditis elegans mucorales; mucormycosis; pathogenesis; infection models; mouse models; Galleria mellonella; Caenorhabditis elegans
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jacobsen, I.D. Animal Models to Study Mucormycosis. J. Fungi 2019, 5, 27.

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