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Journal of Cardiovascular Development and Disease, Volume 9, Issue 2

February 2022 - 34 articles

Cover Story: In this report, Yuan et. al. describe the complex universe of nuclear and cellular division in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in the transition to mononuclear or binuclear cells. Moreover, they observe that self-duplication arises from both mononuclear and binuclear cardiomyocytes in a highly proliferative set of hiPSC-CMs treated with the CHIR99021 molecule. Remarkably, these highly proliferative hiPSC-CMs have an increased ability to incorporate alien DNA, as illustrated by the nuclear expression of mCherry fluorescent protein. View this paper.
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Articles (34)

  • Feature Paper
  • Review
  • Open Access
6 Citations
4,887 Views
28 Pages

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

  • Hummaira Banu Siddiqui,
  • Sedat Dogru,
  • Seyedeh Samaneh Lashkarinia and
  • Kerem Pekkan

During embryonic development, changes in the cardiovascular microstructure and material properties are essential for an integrated biomechanical understanding. This knowledge also enables realistic predictive computational tools, specifically targeti...

  • Review
  • Open Access
11 Citations
5,961 Views
31 Pages

Innate and adaptive leukocytes rapidly mobilize to ischemic tissues after myocardial infarction in response to damage signals released from necrotic cells. Leukocytes play important roles in cardiac repair and regeneration such as inflammation initia...

  • Article
  • Open Access
10 Citations
4,644 Views
21 Pages

DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse

  • Kelsey S. Moore,
  • Reece Moore,
  • Diana B. Fulmer,
  • Lilong Guo,
  • Cortney Gensemer,
  • Rebecca Stairley,
  • Janiece Glover,
  • Tyler C. Beck,
  • Jordan E. Morningstar and
  • Rachel Biggs
  • + 3 authors

Mitral valve prolapse (MVP) is a common cardiac valve disease that often progresses to serious secondary complications requiring surgery. MVP manifests as extracellular matrix disorganization and biomechanically incompetent tissues in the adult setti...

  • Review
  • Open Access
24 Citations
8,792 Views
15 Pages

Mitral valve prolapse (MVP) is a common cause of valvular heart disease. Although many patients with MVP have a benign course, there is increasing recognition of an arrhythmic phenotype associated with ventricular arrhythmias and sudden cardiac death...

  • Article
  • Open Access
1 Citations
4,060 Views
7 Pages

Evaluation of the Association between Fetal Cardiac Disorders with Choroid Plexus Cyst in Fetuses

  • Mohammad Sedigh Dakkali,
  • Arman Karimi Behnagh,
  • Shakiba Ghasemi Assl,
  • Atiyeh Kimiaeifar and
  • Mohammad Radgoodarzi

Choroid plexus cysts (CPCs) are often transient and benign findings observed in pregnancy screenings. This study aimed to examine the association between the frequency of congenital heart diseases and the detection of CPCs. In this prospective case-c...

  • Article
  • Open Access
22 Citations
4,938 Views
9 Pages

Return to Play after SARS-CoV-2 Infection in Competitive Athletes of Distinct Sport Disciplines in Italy: A FMSI (Italian Federation of Sports Medicine) Study

  • Maurizio Casasco,
  • Ferdinando Iellamo,
  • Marco Scorcu,
  • Attilio Parisi,
  • Irena Tavcar,
  • Erica Brugin,
  • Barbara Martini,
  • Chiara Fossati and
  • Fabio Pigozzi

Background: SARS-CoV-2 can lead to several systemic complications, including myocardial injuries; these might be worsened by heavy physical activity. The optimal approach to cardiac risk stratification following SARS-CoV-2 infection in athletes for a...

  • Article
  • Open Access
8 Citations
2,738 Views
11 Pages

(1) Background: ST-elevation myocardial infarction (STEMI) is an inflammatory disease in which neutrophils, macrophages, and lymphocytes accumulate in the ischemic myocardium and have important functions. Nucleolar-organizing regions (NORs) are the s...

  • Case Report
  • Open Access
3 Citations
2,652 Views
7 Pages

Remote dielectric sensing (ReDSTM) is a novel technology that noninvasively quantifies lung fluid levels. Trends in ReDS values following hemodialysis remain uninvestigated. In a 64-year-old man with clinically stable hemodynamics, 2.7 L of fluid was...

  • Article
  • Open Access
25 Citations
4,945 Views
12 Pages

Prognostic Value of Machine Learning in Patients with Acute Myocardial Infarction

  • Changhu Xiao,
  • Yuan Guo,
  • Kaixuan Zhao,
  • Sha Liu,
  • Nongyue He,
  • Yi He,
  • Shuhong Guo and
  • Zhu Chen

(1) Background: Patients with acute myocardial infarction (AMI) still experience many major adverse cardiovascular events (MACEs), including myocardial infarction, heart failure, kidney failure, coronary events, cerebrovascular events, and death. Thi...

  • Review
  • Open Access
18 Citations
5,310 Views
18 Pages

Optimising Cardiometabolic Risk Factors in Pregnancy: A Review of Risk Prediction Models Targeting Gestational Diabetes and Hypertensive Disorders

  • Eleanor P. Thong,
  • Drishti P. Ghelani,
  • Pamada Manoleehakul,
  • Anika Yesmin,
  • Kaylee Slater,
  • Rachael Taylor,
  • Clare Collins,
  • Melinda Hutchesson,
  • Siew S. Lim and
  • Helena J. Teede
  • + 3 authors

Cardiovascular disease, especially coronary heart disease and cerebrovascular disease, is a leading cause of mortality and morbidity in women globally. The development of cardiometabolic conditions in pregnancy, such as gestational diabetes mellitus...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425