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Journal of Cardiovascular Development and Disease, Volume 11, Issue 9

2024 September - 42 articles

Cover Story: This study aimed to investigate cardiac and arterial remodeling before and after thoracic endovascular aortic repair (TEVAR) by measuring the Aorto-Septal Angle (AoSA) and the geometric characteristics of the aorta. Five patients were included, with pre- and post-operative cardio CTA scans used to create patient-specific 3D models. A novel, reproducible method for AoSA measurement was introduced, using the models to perform a semi-automated analysis. The results showed significant variations in AoSA and aortic geometry, suggesting thoracic stent deployment alters AoSA, potentially impacting long-term left ventricle hemodynamics. View this paper
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Articles (42)

  • Review
  • Open Access
2 Citations
6,029 Views
22 Pages

Statins are drugs used in cardiovascular pharmacotherapy to decrease hypercholesterolemia and lower the risk of atherosclerosis. Statins also increase the risk of rhabdomyolysis, which is often minimized in comparison with large relative risk reducti...

  • Review
  • Open Access
7 Citations
3,416 Views
13 Pages

The Role of Coronary Imaging in Chronic Total Occlusions: Applications and Future Possibilities

  • Giuseppe Panuccio,
  • Youssef S. Abdelwahed,
  • Nicole Carabetta,
  • Ulf Landmesser,
  • Salvatore De Rosa and
  • Daniele Torella

Chronic total occlusions (CTOs) represent a challenging scenario in coronary artery disease (CAD). The prevalence of CTOS in patients undergoing coronary angiography underscores the need for effective diagnostic and therapeutic strategies. Coronary a...

  • Article
  • Open Access
2,068 Views
10 Pages

Background: The TactiFlex™ ablation catheter, Sensor Enabled™ (Abbott, Minneapolis, MN, USA), is an open-irrigation radiofrequency (RF) ablation catheter with flexible tip technology. This catheter delivers high-power short-duration (HPSD...

  • Case Report
  • Open Access
2 Citations
1,659 Views
8 Pages

Septal Myectomy in Patients with Hypertrophic Cardiomyopathy and Nonclassical Anderson–Fabry Disease

  • Alexandr Gurschenkov,
  • Sofiya Andreeva,
  • Vadim Zaitsev,
  • Pavel Khazov,
  • Gleb Ischmukhametov,
  • Alexandra Kozyreva,
  • Polina Sokolnikova,
  • Olga Moiseeva,
  • Anna Kostareva and
  • Mikhail Gordeev

Anderson–Fabry disease (AFD) results from decreased enzyme activity of lysosomal enzymes and intralysosomal storage of nonhydrolyzed forms. Cardiovascular complications, mainly in the form of HCM, contribute substantially to AFD patient mortali...

  • Article
  • Open Access
3 Citations
1,496 Views
9 Pages

Serum Klotho Is Elevated in Patients with Acute Myocardial Infarction and Could Predict Poor In-Hospital Prognosis

  • Yuanyuan Pei,
  • Wenfeng Huang,
  • Lingjie Cao,
  • Fengtao Yang,
  • Cheng Chi and
  • Jihong Zhu

Introduction: Klotho has emerged as a potential protective factor for cardiovascular diseases recently. Nevertheless, the levels of serum Klotho in acute coronary syndrome (ACS) have not been reported. Hence, we undertook a study to investigate the p...

  • Feature Paper
  • Review
  • Open Access
6 Citations
5,707 Views
19 Pages

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, with catheter ablation being a key alternative to medical treatment for restoring normal sinus rhythm. Despite advances in understanding AF pathogenesis, approximately 35% of pat...

  • Review
  • Open Access
2 Citations
3,914 Views
18 Pages

Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review

  • Randeep Gill,
  • Arsalan Siddiqui,
  • Brianna Yee,
  • Michael V. DiCaro,
  • Nazanin Houshmand and
  • Tahir Tak

Hypertrophic cardiomyopathy (HCM) is characterized by excessive growth of myocardial tissue, most commonly due to genetic mutations in sarcomere proteins. This can lead to complications such as heart failure, mitral regurgitation, syncope, arrhythmia...

  • Systematic Review
  • Open Access
4 Citations
4,712 Views
14 Pages

Nutritional Interventions in Older Persons with Type 2 Diabetes and Frailty: A Scoping Systematic Review

  • German C. Giraldo Gonzalez,
  • Luz M. González Robledo,
  • Isabel C. Jaimes Montaña,
  • Angela M. Benjumea Salgado,
  • Sayda M. Pico Fonseca,
  • Martha J. Arismendi Solano and
  • Claudia L. Valencia Rico

In the elderly, the coexistence of type 2 diabetes mellitus (T2DM) and frailty is frequent. Much has been described about pharmacological management and glycemic control goals. However, there is a knowledge gap in terms of the objectives and characte...

  • Case Report
  • Open Access
1 Citations
1,509 Views
6 Pages

We report on a 14-year-old patient who was supported for nearly two years with an ic-LVAD and managed to complete his journey to transplantation without a single complication. Although mechanical assist device support is available for children up to...

  • Article
  • Open Access
2,068 Views
11 Pages

Lifestyle Habits and Risk of Cardiovascular Mortality in Menopausal Women with Cardiovascular Risk Factors: A Retrospective Cohort Study

  • Adriana Lopez-Pineda,
  • Cristina Soriano-Maldonado,
  • Vicente Arrarte,
  • Francisco Sanchez-Ferrer,
  • Vicente Bertomeu-Gonzalez,
  • Juan Miguel Ruiz-Nodar,
  • Jose A. Quesada and
  • Alberto Cordero

Current cardiovascular prevention guidelines emphasise considering sex, gender, and gender identity in risk assessment. This study evaluated the impact of lifestyle habits and chronic diseases on cardiovascular mortality risk in women over 50 with hi...

  • Article
  • Open Access
2 Citations
6,381 Views
9 Pages

Addition of Bempedoic Acid to Statin–Ezetimibe versus Statin Titration in Patients with High Cardiovascular Risk: A Single-Centre Prospective Study

  • Giuseppe Marazzi,
  • Giuseppe Caminiti,
  • Marco Alfonso Perrone,
  • Giuseppe Campolongo,
  • Luca Cacciotti,
  • Domenico Mario Giamundo,
  • Ferdinando Iellamo,
  • Paolo Severino,
  • Maurizio Volterrani and
  • Giuseppe Rosano

Reducing levels of low-density lipoprotein cholesterol (LDL-C) below recommended thresholds is a core component of cardiovascular prevention strategies. We hypothesized that the addition of bempedoic acid to patients already on statin–ezetimibe thera...

  • Article
  • Open Access
1 Citations
2,486 Views
10 Pages

Effect of Sport Activity on Uncomplicated Bicuspid Aortic Valve: Long-Term Longitudinal Echocardiographic Study

  • Massimiliano Bianco,
  • Fabrizio Sollazzo,
  • Gloria Modica,
  • Isabella Carlotta Zovatto,
  • Rachele Di Mario,
  • Riccardo Monti,
  • Michela Cammarano,
  • Vincenzo Palmieri and
  • Paolo Zeppilli

Background: The bicuspid aortic valve (BAV) is a congenital heart defect that can lead to certain complications (aortic stenosis, regurgitation, dilatation and endocarditis), the diagnosis and clinical monitoring of which are effectively entrusted to...

  • Article
  • Open Access
1,712 Views
11 Pages

The Effect of Upright Posture on Left Atrial Strain in Competitive Athletes

  • Joscha Kandels,
  • Stephan Stöbe,
  • Robert Percy Marshall,
  • Andreas Hagendorff and
  • Michael Metze

Background: Left atrial strain (LAS) assessment by speckle tracking echocardiography (STE) has been shown to be a remarkable means of quantifying LA function as an early marker of LV pathology. As exercise testing is also performed on a treadmill, th...

  • Article
  • Open Access
2 Citations
3,648 Views
11 Pages

Comparison of ECMO, IABP and ECMO + IABP in the Postoperative Period in Patients with Postcardiotomy Shock

  • Cagdas Baran,
  • Evren Ozcinar,
  • Ahmet Kayan,
  • Nur Dikmen,
  • Canan Soykan Baran and
  • Mustafa Bahadir Inan

Background: This study aims to assess the outcomes and complications of patients who received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and intra-aortic balloon pump (IABP) support after cardiac surgery at Ankara University Heart Ce...

  • Editorial
  • Open Access
1,183 Views
3 Pages

Arrhythmic risk stratification is challenging for cardiologists managing patients with different forms of cardiomyopathy, ranging from post-ischemic or non-ischemic cardiomyopathies to systemic diseases with cardiac involvement such as neuromuscular...

  • Article
  • Open Access
1,587 Views
10 Pages

Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis

  • Estefania Oliveros,
  • Michel Ibrahim,
  • Carlos Manuel Romero,
  • Paul Navo,
  • Patricia Otero Valdes,
  • Yevgeniy Brailovsky,
  • Amir Darki,
  • Riyaz Bashir,
  • Anjali Vaidya and
  • Chandra Dass
  • + 1 author

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of incomplete resolution of acute pulmonary embolism. We hypothesize changes in CT Hounsfield Unit gradient (HU-Δ) created by the dispersion of IV contrast through the down...

  • Article
  • Open Access
3 Citations
3,602 Views
12 Pages

Regular and long-term shift work is associated with a number of chronic diseases. There is some evidence that shift work also has an influence on the autonomous nervous system. Studies that have examined the effect of shift work on heart rate variabi...

  • Article
  • Open Access
3,097 Views
13 Pages

Background: Resistant hypertension (HTN) is associated with a high risk of cardiovascular complications. Our study aimed to assess the prevalence, characteristics, and treatment of patients with resistant HTN. Methods: We screened 4340 consecutive ca...

  • Article
  • Open Access
5 Citations
1,821 Views
12 Pages

Diagnosing congenital heart disease (CHD) remains challenging because of its complex morphology. Representing the intricate structures of CHD on conventional two-dimensional flat screens is difficult owing to wide variations in the pathologies. Techn...

  • Article
  • Open Access
4 Citations
2,540 Views
19 Pages

The Role of P Wave Parameters in Predicting Pulmonary Vein Isolation Outcomes for Paroxysmal Atrial Fibrillation: An Observational Cohort Study

  • Ibrahim Antoun,
  • Xin Li,
  • Ahmed I. Kotb,
  • Zakkariya Vali,
  • Ahmed Abdelrazik,
  • Abdulmalik Koya,
  • Akash Mavilakandy,
  • Ivelin Koev,
  • Ali Nizam and
  • André Ng
  • + 2 authors

Background: Pulmonary vein isolation (PVI) is an effective management method for paroxysmal atrial fibrillation (PAF). The P wave in the 12-lead electrocardiogram (ECG) represents atrial depolarisation. This study aims to utilise the P wave to predic...

  • Article
  • Open Access
1 Citations
1,808 Views
11 Pages

The aim of this study was to inviestigate cardiac and arterial remodelling before and after thoracic endovascular aortic repair (TEVAR) by measuring the Aorto-Septal Angle (AoSA) and the geometric characteristics of the aorta. Five patients were pros...

  • Article
  • Open Access
1,882 Views
9 Pages

Progression, Management, and Outcome of Aortic Valve Stenosis in Systemic Sclerosis: A Case Series

  • Andrea Vergara,
  • Antonio Orlando,
  • Eleonora Caiazza,
  • Serena Vettori,
  • Giovanna Cuomo,
  • Paola Argiento,
  • Emanuele Romeo,
  • Rosa Franzese,
  • Berardo Sarubbi and
  • Michele D’Alto

Background: In systemic sclerosis (SSc), cardiac involvement is frequent, heterogeneous, and related to a poor prognosis. Due to a longer life expectancy, the development of degenerative aortic stenosis (AS) is not uncommon. The aim of this article i...

  • Systematic Review
  • Open Access
1 Citations
2,512 Views
16 Pages

Background. The effect of statins on CIMT progression and C-reactive protein (CRP) in T2DM patients is widely reported. However, some studies demonstrated no effect of statins on CIMT and CRP in T2DM patients, while others reported otherwise. Thus, t...

  • Review
  • Open Access
4 Citations
3,741 Views
21 Pages

Direct Cardiac Reprogramming in the Age of Computational Biology

  • Rachelle Ambroise,
  • Paige Takasugi,
  • Jiandong Liu and
  • Li Qian

Heart disease continues to be one of the most fatal conditions worldwide. This is in part due to the maladaptive remodeling process by which ischemic cardiac tissue is replaced with a fibrotic scar. Direct cardiac reprogramming presents a unique solu...

  • Article
  • Open Access
1 Citations
3,383 Views
13 Pages

Mortality Predictors and Neurological Outcomes Following Extracorporeal Cardiopulmonary Resuscitation (eCPR): A Single-Center Retrospective Study

  • Sasa Rajsic,
  • Helmuth Tauber,
  • Robert Breitkopf,
  • Corinna Velik Salchner,
  • Fabian Mayer,
  • Ulvi Cenk Oezpeker and
  • Benedikt Treml

Background: Extracorporeal cardiopulmonary resuscitation (eCPR) offers cardiorespiratory support to patients experiencing cardiac arrest. However, this technology is not yet considered a standard treatment, and the evidence on eCPR criteria and its a...

  • Article
  • Open Access
3 Citations
3,231 Views
13 Pages

Subclinical Atherosclerosis Progression in Low-Risk, Middle-Aged Adults: Carotid Leads Femoral in IMT Increase but Not in Plaque Formation

  • Eva Szabóová,
  • Alexandra Lisovszki,
  • Alojz Rajnič,
  • Peter Kolarčik,
  • Peter Szabó,
  • Tomáš Molnár and
  • Lucia Dekanová

This study investigated subclinical atherosclerosis progression in low-risk, middle-aged adults (N = 141; a mean age of 49.6 ± 4.7 years) using a 5-year ultrasound follow-up. We compared the involvement of the carotid and femoral arteries. Met...

  • Brief Report
  • Open Access
2 Citations
1,636 Views
6 Pages

Remote Monitoring: How to Maximize Efficiency through Appropriate Organization in a Device Clinic

  • Massimiliano Maines,
  • Giancarlo Tomasi,
  • Luisa Poian,
  • Marzia Simoncelli,
  • Debora Zeni,
  • Monica Santini and
  • Maurizio Del Greco

Introduction: Remote device monitoring is indicated under class I A standard of care according to the latest HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Practical Management of the Remote Device Clinic. Despite this strong endorsement and the...

  • Article
  • Open Access
4,103 Views
9 Pages

Anticoagulation Patterns in Ischemic Stroke Patients with Atrial Fibrillation in Developing Country: Insights from the Stroke Registry in Vietnam

  • Mai Duy Ton,
  • Dao Viet Phuong,
  • Nguyen Tien Dung,
  • Nguyen Van Chi,
  • Truong Thi Hoa,
  • Tran Cong Minh,
  • Jeyaraj Pandian and
  • Nguyen Huy Thang

(1) Background: Atrial fibrillation (AF) poses a growing cardiovascular challenge globally, with significant implications in Vietnam. This study aimed to investigate the impact of AF on ischemic stroke/transient ischemic attack (TIA) and clinical out...

  • Article
  • Open Access
2,097 Views
12 Pages

Many people with diagnosed hypertension, high cholesterol, and/or diabetes are not receiving drug treatment, partly because they perceive their cardiovascular disease (CVD) risk as low. This study aimed to quantify the risk for future CVD events, eit...

  • Review
  • Open Access
2 Citations
2,543 Views
16 Pages

The developmental changes in the excitation–contraction mechanisms of the ventricular myocardium of small animals (guinea pig, rat, mouse) and their sympathetic regulation will be summarized. The action potential duration monotonically decrease...

  • Article
  • Open Access
2 Citations
2,924 Views
9 Pages

Hypertension-Mediated Organ Damage in Relation to Severity of Chronic Low Back Pain in Hypertensive Patients

  • Maciej Skrzypek,
  • Rafał Kolec,
  • Michał Słaboszewski,
  • Katarzyna Góra,
  • Agnieszka Olszanecka,
  • Piotr Wróbel,
  • Katarzyna Stolarz-Skrzypek and
  • Marek W. Rajzer

Introduction: Chronic pain triggers a stress response, which results in increased blood pressure (BP). We investigated whether chronic low back pain (cLBP) in hypertensive patients is associated with an increased risk of hypertension-related organ da...

  • Article
  • Open Access
1 Citations
1,750 Views
10 Pages

Characteristics, Treatment, and Prognosis of Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the Colombian Heart Failure Registry (RECOLFACA)

  • Jorge Alberto Sandoval-Luna,
  • Alex Rivera-Toquica,
  • Clara Saldarriaga,
  • Erika Martínez-Carreño,
  • Alexis Llamas,
  • Gustavo Adolfo Moreno-Silgado,
  • Julián Vanegas-Eljach,
  • Nelson Eduardo Murillo-Benítez,
  • Ricardo Gómez-Palau and
  • Juan Esteban Gómez-Mesa
  • + 5 authors

The impact of chronic obstructive pulmonary disease (COPD) on heart failure (HF) has yet to be well assessed in the Latin American population. This study aimed to analyze the impact of COPD on HF patients from the Colombian Heart Failure Registry (RE...

  • Article
  • Open Access
1,651 Views
10 Pages

Exploring Sex Differences in Pain Manifestation of Coronary Artery Disease through Mendelian Randomization

  • Ruben Methorst,
  • Monique R. M. Jongbloed,
  • Raymond Noordam and
  • Marco C. DeRuiter

Pain manifestation following coronary artery disease (CAD) disease differs between men and women. Here, we aimed to provide evidence favoring possible differences in pain manifestation between men and women following CAD using Mendelian randomization...

  • Review
  • Open Access
3 Citations
3,299 Views
26 Pages

Cancer and Heart Failure: Dangerous Liaisons

  • Davide Bertolini,
  • Carmine Pizzi,
  • Erwan Donal and
  • Elena Galli

Cancer and heart failure (HF) are increasingly relevant worldwide, both from an epidemiologic and clinical point of view. This review aims to explore the relationship between cancer and HF by underscoring risk factors and disclosing the cardiotoxic e...

  • Article
  • Open Access
6 Citations
5,312 Views
11 Pages

Apical sparing is an echocardiographic pattern where myocardial strain is preserved at the apex compared to the basal segments. In a normal heart, longitudinal strain shows a gradient with lower values at the base and higher at the apex. This gradien...

  • Article
  • Open Access
5 Citations
2,134 Views
12 Pages

Background and Objectives: Chronic total occlusion (CTO) is a complex lesion of coronary artery disease (CAD) with a detection rate of approximately 25% on coronary angiography. CTO patients generally experience poor quality of life and prognosis. Th...

  • Review
  • Open Access
8 Citations
4,123 Views
15 Pages

Spinal Cord Stimulation for Intractable Chronic Limb Ischemia: A Narrative Review

  • Roberto Gazzeri,
  • Tommaso Castrucci,
  • Matteo Luigi Giuseppe Leoni,
  • Marco Mercieri and
  • Felice Occhigrossi

Critical limb ischemia (CLI) is the most severe form of peripheral arterial disease, significantly impacting quality of life, morbidity and mortality. Common complications include severe limb pain, walking difficulties, ulcerations and limb amputatio...

  • Brief Report
  • Open Access
1 Citations
2,037 Views
9 Pages

The Role of Cardiac Magnetic Resonance in mRNA COVID-19 Vaccine-Related Myopericarditis: An Evolutive Case Series

  • Gisela Feltes,
  • Violeta Sánchez Sánchez,
  • Esther Pérez-David,
  • José Luis Moreno-Hurtrez,
  • Juan Delgado Jiménez and
  • Iván J. Núñez-Gil

Numerous cases of myocarditis related to mRNA vaccines for COVID-19 have recently been described, usually in young men. Long-term evolutive cardiac magnetic resonance imaging (CMR) data are lacking. We describe four consecutive cases of COVID-19 vacc...

  • Article
  • Open Access
3 Citations
2,477 Views
12 Pages

A Multi-Biomarker Approach to Increase the Accuracy of Diagnosis and Management of Coronary Artery Disease

  • Lenka Hostačná,
  • Jana Mašlanková,
  • Dominik Pella,
  • Beáta Hubková,
  • Mária Mareková and
  • Daniel Pella

Non-invasive possibilities of predicting cardiovascular risk and monitoring the treatment and progression of coronary artery disease (CAD) are important subjects of cardiovascular research. Various inflammatory markers have been identified as potenti...

  • Review
  • Open Access
6 Citations
33,191 Views
16 Pages

Diagnosis and Treatment of Eclampsia

  • Vasiliki Katsi,
  • Asimenia Svigkou,
  • Ioanna Dima and
  • Konstantinos Tsioufis

Hypertensive disorders of pregnancy affect approximately 5% to 10% of pregnant women. Eclampsia is a serious hypertensive disorder that is primarily characterized by the onset of grand mal seizure activity in the absence of other causative conditions...

  • Article
  • Open Access
1,313 Views
7 Pages

The study assessed the epidemiological frequency and prognostic impact of new-onset cancer as an additional net adverse clinical outcome in patients after ST-elevation myocardial infarction (STEMI), considering its potential clinical significance alo...

  • Article
  • Open Access
2 Citations
2,641 Views
12 Pages

Evaluating the Clinical Effectiveness of Cardiac Rehabilitation among Patients of Very Low Socioeconomic Status Living in Colombia

  • Gabriela L. M. Ghisi,
  • Ana Paula Delgado Bomtempo,
  • Nelson F. Gonzalez,
  • Giovanna Patricia Reyes and
  • Claudia V. Anchique

Cardiovascular disease (CVD) poses a significant health burden, particularly among individuals of low socioeconomic status (SES) in low- and middle-income countries (LMICs). This study evaluates the clinical effectiveness of cardiac rehabilitation (C...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425