Vinorelbine as First-Line Treatment in Stage IV Canine Primary Pulmonary Carcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Treatment
2.3. Follow-Up
2.4. Endpoint
2.5. Statistical Analysis
3. Results
3.1. Patient Population
3.2. Administration of Vinorelbine and Adverse Events
3.3. Tumour Response
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Primary Tumour Features | |
---|---|
T0 | No evidence of tumour |
TX | Tumour proven by presence of malignant cells in bronchopulmonary secretions but not seen via radiography or bronchoscopy |
T1 | Solitary tumour surrounded by lung or visceral pleura |
T2 | Multiple tumours of any size |
T3 | Tumour invading neighbouring tissues |
Regional lymph nodes (RLN) | |
N0 | No evidence of RLN involvement |
N1 | Bronchial LN involved |
N2 | Distant LN involved |
Distant metastasis | |
M0 | No evidence of distant metastasis |
M1 | Distant metastasis detected |
T | Size (cm) | Solitary vs. Multiple Nodules | Organ Invasion |
---|---|---|---|
T1 | ≤3 | Solitary | None |
T2 | >3 to ≤5 | Solitary | Visceral pleura, main bronchi (not carina) |
T3 | >5 to ≤7 | Separate nodule(s) in same lobe | Chest wall, pericardium, phrenic nerve |
T4 | >7 | Separate nodule(s) in ipsilateral lung lobe(s) | Mediastinum, diaphragm, heart, great vessels, recurrent laryngeal, nerve, carina, trachea, oesophagus, spine |
N | |||
N0 | No lymph node metastasis | ||
N1 | Ipsilateral tracheobronchial lymph node | ||
N2 | Distant lymph node metastasis | ||
M | |||
M0 | No distant metastasis | ||
M1 | Malignant effusion, contralateral lung lobe metastasis, extra-thoracic metastasis | ||
Stage 1 | T1, N0, M0 | ||
Stage 2 | T2, N0, M0; T3, N0, M0; T1–2, N1, M0 | ||
Stage 3 | T4, N0, M0; T3–4, N1, M0; T1–4, N2, M0 | ||
Stage 4 | T1–4, N1–2, M1 |
N° | Breed | Age (Years) | Sex | Weight (Kg) |
1 | Bernese Mountain | 8 | M | 37 |
2 | Crossbreed | 4 | SF | 4 |
3 | American Staffordshire Terrier | 13 | NM | 35 |
4 | Border Collie | 10 | SF | 21 |
5 | Border Collie | 7 | M | 24 |
6 | Crossbreed | 11 | M | 25 |
7 | Crossbreed | 10 | NM | 22 |
8 | Crossbreed | 10 | SF | 27 |
9 | English Setter | 7 | NM | 27 |
10 | English Setter | 8 | F | 28 |
N° | Clinical Signs | Pleural Effusion | Tumour Location | Total Number of VRL Administrations | VCOG Toxicity | TTP (Days) | ST (Days) |
---|---|---|---|---|---|---|---|
1 | None | NO | Pulmonary + Hepatic Mts | 8 | A grade II V grade I | 88 | 160 |
2 | Dyspnea | YES | Diffuse Pulmonary | 8 * | N grade IV V grade I | 84 | 635 |
3 | Weight Loss | NO | Diffuse Pulmonary | 10 | NO | 112 | 120 |
4 | Weight Loss | NO | Hepatic Mts | 8 | NO | 90 | 90 |
5 | Dyspnea | YES | Diffuse Pulmonary + Hepatic Mts | 1 | NV | 7 | 7 |
6 | Cough | NO | Diffuse Pulmonary | 8 * | N grade II | 84 | 100 |
7 | Weight Loss | NO | Diffuse Pulmonary | 8 * | NO | 90 | 90 |
8 | None | NO | Diffuse Pulmonary | 9 | N grade II | 98 | 100 |
9 | Dyspnea | YES | Diffuse Pulmonary | 8 | N grade I | 84 | 90 |
10 | None | NO | Diffuse Pulmonary | 10 | N grade I | 112 | 120 |
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Rinaldi, V.; Finotello, R.; Boari, A.; Cabibbo, E.; Crisi, P.E. Vinorelbine as First-Line Treatment in Stage IV Canine Primary Pulmonary Carcinoma. Vet. Sci. 2023, 10, 664. https://doi.org/10.3390/vetsci10120664
Rinaldi V, Finotello R, Boari A, Cabibbo E, Crisi PE. Vinorelbine as First-Line Treatment in Stage IV Canine Primary Pulmonary Carcinoma. Veterinary Sciences. 2023; 10(12):664. https://doi.org/10.3390/vetsci10120664
Chicago/Turabian StyleRinaldi, Valentina, Riccardo Finotello, Andrea Boari, Emanuele Cabibbo, and Paolo Emidio Crisi. 2023. "Vinorelbine as First-Line Treatment in Stage IV Canine Primary Pulmonary Carcinoma" Veterinary Sciences 10, no. 12: 664. https://doi.org/10.3390/vetsci10120664