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Bioengineering 2019, 6(1), 4;

Stem Cell Extracellular Vesicles in Skin Repair

Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, 1501 NW 10th Ave, Miami, FL 33136, USA
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627-Pampulha, Belo Horizonte-MG 31270-901, Brazil
Author to whom correspondence should be addressed.
Received: 30 November 2018 / Revised: 19 December 2018 / Accepted: 25 December 2018 / Published: 30 December 2018
(This article belongs to the Special Issue Extracellular Vesicles: From Biology to Biomedical Applications)
PDF [309 KB, uploaded 1 January 2019]


Stem cell extracellular vesicles (EVs) have been widely studied because of their excellent therapeutic potential. EVs from different types of stem cell can improve vascularization as well as aid in the treatment of cancer and neurodegenerative diseases. The skin is a complex organ that is susceptible to various types of injury. Strategies designed to restore epithelial tissues’ integrity with stem cell EVs have shown promising results. Different populations of stem cell EVs are able to control inflammation, accelerate skin cell migration and proliferation, control wound scarring, improve angiogenesis, and even ameliorate signs of skin aging. However, large-scale production of such stem cell EVs for human therapy is still a challenge. This review focuses on recent studies that explore the potential of stem cell EVs in skin wound healing and skin rejuvenation, as well as challenges of their use in therapy. View Full-Text
Keywords: extracellular vesicles; exosomes; stem cells; mesenchymal stem cells; skin repair extracellular vesicles; exosomes; stem cells; mesenchymal stem cells; skin repair

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ferreira, A.F.; Gomes, D.A. Stem Cell Extracellular Vesicles in Skin Repair. Bioengineering 2019, 6, 4.

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