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Toxics, Volume 12, Issue 3

March 2024 - 68 articles

Cover Story: Despite firefighting being classified as carcinogenic to humans, the underlying biological mechanisms have yet to be fully understood. Comprehending firefighters’ occupational exposure across various settings and time points of their activity is crucial. We characterized firefighters’ occupational exposure to particulate matter in fire stations prior to the wildfire season in the Northern region of Portugal. The biological impact of estimated inhaled doses of PM10 and PM2.5 (indoor/outdoor) was accessed through buccal micronucleus cytome assay in exfoliated buccal cells. Our findings provide the essential baseline for further studies assessing exposure during the wildfire season, highlighting the importance of biomonitoring programs to identify individuals predisposed to adverse health outcomes. View this paper
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Articles (68)

  • Article
  • Open Access
2,697 Views
27 Pages

Indications of Endocrine Disruptor Effects of JP-5 Jet Fuel Using a Rat-Model Reproductive Study and an In Vitro Human Hormone Receptor Assay

  • William R. Howard,
  • Joyce G. Rohan,
  • Kimberly S. B. Yeager,
  • Chester P. Gut,
  • Kathleen A. Frondorf,
  • Shawn M. McInturf,
  • Nathan M. Gargas and
  • Karen L. Mumy

16 March 2024

Recent events concerning jet fuel contamination of drinking water have shown that we need a better understanding of the effects of ingested jet fuel. To this end, a reproductive study with ingested jet fuel in rats was undertaken with relatively high...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,503 Views
18 Pages

A Proof-of-Concept for a Hypolipidemic Brown Trout Model

  • Tiago Lourenço,
  • Eduardo Rocha,
  • José Fernando Gonçalves,
  • Maria João Rocha and
  • Tânia Vieira Madureira

15 March 2024

The impacts of hypolipidemic pharmaceuticals on fish lipid metabolism remain unexplored. However, data points to similar effects and mechanisms of action between fish and humans. Therefore, fish may be a strong model for screening hypolipidemic drug...

  • Review
  • Open Access
7 Citations
3,134 Views
22 Pages

15 March 2024

Pyrethroids, which are derived from natural insecticides found in chrysanthemum flowers, are widely utilized in various sectors, including agriculture, forestry, horticulture, and personal insect protection. Due to their widespread use, concerns have...

  • Article
  • Open Access
5 Citations
2,627 Views
24 Pages

Mechanism of the Synergistic Toxicity of Ampicillin and Cefazoline on Selenastrum capricornutum

  • Feng-Ling Huang,
  • Li-Tang Qin,
  • Ling-Yun Mo,
  • Hong-Hu Zeng and
  • Yan-Peng Liang

14 March 2024

Ampicillin (AMP) and cefazolin (CZO) are commonly used β-lactam antibiotics which are extensively globally produced. Additionally, AMP and CZO are known to have relatively high ecotoxicity. Notably, the mix of AMP and CZO creates a synergistic e...

  • Article
  • Open Access
1 Citations
2,526 Views
19 Pages

14 March 2024

Background: Inhalation exposure to carcinogenic metals such as cadmium (Cd) is a significant global health concern linked to various cancers. However, the precise carcinogenic mechanism underlying inhalation exposure remains elusive. Methods: In this...

  • Article
  • Open Access
8 Citations
3,532 Views
14 Pages

Differential Disruption of Glucose and Lipid Metabolism Induced by Phthalates in Human Hepatocytes and White Adipocytes

  • Yaru Tian,
  • Miao Xu,
  • Hailin Shang,
  • Lijuan You,
  • Jing Yang,
  • Xudong Jia,
  • Hui Yang,
  • Yongning Wu,
  • Xingfen Yang and
  • Yi Wan

14 March 2024

Phthalic acid esters (PAEs), commonly used as plasticizers, are pervasive in the environment, leading to widespread human exposure. The association between phthalate exposure and metabolic disorders has been increasingly recognized, yet the precise b...

  • Article
  • Open Access
7 Citations
2,347 Views
14 Pages

Riparian Soil Pollution Caused by Sediment Metal Transport: Seasonal Changes and Ecological Risk Assessment

  • Ahmet Çelebi,
  • Bülent Şengörür,
  • Ali Torabi Haghighi and
  • Ali Danandeh Mehr

13 March 2024

The accumulation of pollutants in the sediment along surface water may negatively affect riparian zones and increase ecological risk. This article investigates the effects of metal sediments on riparian soil via field monitoring and ICP-OES analysis....

  • Article
  • Open Access
14 Citations
5,218 Views
17 Pages

Long-Term Environmental Methylmercury Exposure Is Associated with Peripheral Neuropathy and Cognitive Impairment among an Amazon Indigenous Population

  • Bruno H. Rebouças,
  • Gabriel T. Kubota,
  • Rogério A. A. Oliveira,
  • Bruna D. Pinto,
  • Roberta M. Cardoso,
  • Ana C. S. Vasconcellos and
  • Paulo C. Basta

12 March 2024

Widespread contamination of the Amazon basin with mercury has been reported to occur since at least the mid-80s due to heavy gold mining activity. Although initial studies have indicated that this may lead to deleterious neurological consequences to...

  • Feature Paper
  • Article
  • Open Access
1,718 Views
19 Pages

Redox Homeostasis Disclosed in the Saltmarsh Plant Halimione portulacoides upon Short Waterborne Exposure to Inorganic Mercury

  • Patrícia Pereira,
  • Joana Luísa Pereira,
  • Ana Marques,
  • Carlos Marques,
  • Fátima Brandão,
  • Rute Cesário,
  • Silja Frankenbach,
  • João Serôdio,
  • Fernando J. M. Gonçalves and
  • João Canário
  • + 1 author

12 March 2024

The saltmarsh plant Halimione portulacoides was shortly exposed to realistic levels of inorganic mercury (iHg) with the aim of investigating the adaptative processes of the roots and leaves regarding redox homeostasis, physiology, and Hg accumulation...

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Toxics - ISSN 2305-6304