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Photonics 2019, 6(1), 10; https://doi.org/10.3390/photonics6010010

Imaging of Chemical Reactions Using a Terahertz Chemical Microscope

1
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushimanaka, Kitaku, Okayama 700-8530, Japan
2
Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kitaku, Okayama 700-8530, Japan
3
Kyowa Fintech Co. Ltd., 948-9 Kanaokanishi, Higashiku, Okayama 704-8193, Japan
*
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 22 January 2019 / Accepted: 25 January 2019 / Published: 27 January 2019
(This article belongs to the Special Issue Terahertz Photonics)
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Abstract

This study develops a terahertz (THz) chemical microscope (TCM) that visualizes the distribution of chemical reaction on a silicon-based sensing chip. This chip, called the sensing plate, was fabricated by depositing Si thin films on a sapphire substrate and thermally oxidizing the Si film surface. The Si thin film of the sensing plate was irradiated from the substrate side by a femtosecond laser, generating THz pulses that were radiated into free space through the surface field effect of the Si thin film. The surface field responds to chemical reactions on the surface of the sensing plate, changing the amplitude of the THz pulses. This paper first demonstrates the principle and experimental setup of the TCM and performs the imaging and measurement of chemical reactions, including the reactions of bio-related materials. View Full-Text
Keywords: terahertz; chemical reaction; bio-related materials; femtosecond laser; imaging; ion; immune reactions; antibody; antigen terahertz; chemical reaction; bio-related materials; femtosecond laser; imaging; ion; immune reactions; antibody; antigen
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kiwa, T.; Kamiya, T.; Morimoto, T.; Fujiwara, K.; Maeno, Y.; Akiwa, Y.; Iida, M.; Kuroda, T.; Sakai, K.; Nose, H.; Kobayashi, M.; Tsukada, K. Imaging of Chemical Reactions Using a Terahertz Chemical Microscope. Photonics 2019, 6, 10.

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