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Separations, Volume 10, Issue 5

2023 May - 50 articles

Cover Story: Marigold essential oil is a product of great industrial interest, due to its anti-inflammatory, antimicrobic, and wound healing properties. However, the development of a proper extraction technique is still an issue. In the present work, supercritical fluid extraction coupled with fractional separation was used to recover fragrance compounds from a marigold semi-finished material. In particular, the product of n-hexane extraction from marigold flowers (“concrete”) was utilized; this strategy represents a way to overcome the limitations of treating large volumes of vegetable material and seasonality constraints. Therefore, by changing the operating pressure and CO2 flow rate, extraction efficiency from marigold concrete was studied, and GC-MS analysis demonstrated that the fractionation between marigold essential oil and its waxes was successful. View this paper
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Articles (50)

  • Article
  • Open Access
5 Citations
2,357 Views
11 Pages

Azo dyes such as Congo red can easily cause cancer when they come into contact or are absorbed by the human body, so it is urgent to find a fast and simple method for degrading Congo red. In order to better achieve this research goal, an ultrasonic m...

  • Article
  • Open Access
3 Citations
3,212 Views
23 Pages

Capillary zone electrophoresis (CZE) is an important technique for the analysis of monoclonal antibodies (mAbs). A recently released light-emitting diode (LED)-induced fluorescence (LEDIF) detector equipped with a 275 nm LED for the detection of prot...

  • Article
  • Open Access
2 Citations
1,945 Views
16 Pages

This paper presents a numerical study of a closed-cycle evaporation system for the desalination of seawater. The system couples the condensing end of a heat pump with a humidifier, where the air is dehumidified in the heat pump evaporator. First, the...

  • Article
  • Open Access
10 Citations
2,930 Views
14 Pages

Application of Quality by Design Approach in the Optimization and Development of the UPLC Analytical Method for Determination of Fusidic Acid in Pharmaceutical Products

  • Mohamed Ibrahim,
  • Nasser Ali Alhabib,
  • Doaa Alshora,
  • Mounir M. Salem Bekhit,
  • Ehab Taha,
  • Wael A. Mahdi and
  • Abdulelah M. Harthi

Background: Analytical techniques are a crucial method used in quality control procedures. Fusidic acid (FU), an antibacterial drug, is available on the market in a semisolid dosage form. This work aimed to develop a simple, sensitive, and robust UPL...

  • Review
  • Open Access
6 Citations
2,419 Views
17 Pages

Membrane technology is an advanced hydrogen separation method that is of great significance in achieving hydrogen economy. Rare earth tungstate membranes have both high hydrogen permeability and remarkable mechanical/chemical stability, exhibiting go...

  • Article
  • Open Access
11 Citations
2,582 Views
15 Pages

Sunlight-Driven Degradation of Alprazolam and Amitriptyline by Application of Binary Zinc Oxide and Tin Oxide Powders

  • Nina Finčur,
  • Daniela Šojić Merkulov,
  • Predrag Putnik,
  • Vesna Despotović,
  • Nemanja Banić,
  • Szabolcs Bognár,
  • Dušica Jovanović,
  • Sanja Panić,
  • Tamara Ivetić and
  • Biljana Abramović

In recent years, much attention has been paid to pharmaceuticals as potential toxic bioactive substances in the worldwide environment. These compounds are continuously introduced into the surroundings in small concentrations, which certainly affects...

  • Protocol
  • Open Access
6 Citations
9,416 Views
15 Pages

Untargeted metabolomics approaches require complex samples containing the endogenous metabolites of a biological system. Here, we describe a set of protocols that can be applied to various types of samples, including prokaryotic and eukaryotic cells,...

  • Editorial
  • Open Access
4 Citations
3,809 Views
6 Pages

The Special Issue “Food Quality and Safety: Advances in Analytical Methods and Applications” was open to expert reviews and original contributions dealing with advances in analytical methods for the detection and quantification of potenti...

  • Article
  • Open Access
8 Citations
3,644 Views
15 Pages

Phenolic compounds are important secondary metabolites often found in nature, and most prominently in plants. Plant biomass residues can be a sustainable source of this high-added-value group of compounds that can be used in the food and cosmetics in...

  • Article
  • Open Access
2 Citations
1,826 Views
11 Pages

In the Chinese city of Wuchang, Heilongjiang Province, a survey was conducted to track the concentrations and distributions of several organic pollutants near drinking water reservoirs, such as conventional organochlorine pesticides (OCPs) and curren...

  • Article
  • Open Access
8 Citations
7,425 Views
11 Pages

Poly-diallyldimethylammonium (PDADMAC) chloride is a flocculant agent extensively used in water clarification treatments. Commercial polyelectrolyte formulations often contain residual monomer (DADMAC), reaction by-products and other reactants as con...

  • Article
  • Open Access
14 Citations
2,449 Views
20 Pages

Removal of Sr(II) in Aqueous Solutions Using Magnetic Crayfish Shell Biochar

  • Wenchao Lu,
  • Jundong Feng,
  • Marta Otero,
  • Tao Liao and
  • Liang Qiu

The cooling water of nuclear power plants and discarded crayfish shells (CS), both containing Sr(II), are waste resources that cause environmental pollution and endanger human health. In this study, magnetic biochar produced by crayfish shells (mag@C...

  • Article
  • Open Access
4 Citations
1,995 Views
17 Pages

Bifunctional Adsorbents Based on Jarosites for Removal of Inorganic Micropollutants from Water

  • Arely Monserrat López-Martínez,
  • Sasirot Khamkure and
  • Prócoro Gamero-Melo

This paper presents a novel family of jarosites with the molecular formula MFe3(SO4)2(OH)6·xH2O; M = Na, K, NH4 that have high efficiency in the adsorption of As(V) and Pb(II) dissolved in water. The jarosites have been prepared by conventional heati...

  • Article
  • Open Access
5 Citations
6,714 Views
13 Pages

HPLC-DAD Development and Validation Method for Short-Chain Fatty Acids Quantification from Chicken Feces by Solid-Phase Extraction

  • Lenin Rodolfo Díaz-Corona,
  • Karina Jeanette Parra-Saavedra,
  • Renata Sofia Mora-Alonzo,
  • María Esther Macías-Rodríguez,
  • Alma H. Martínez-Preciado,
  • Santiago José Guevara-Martínez,
  • Adalberto Zamudio-Ojeda and
  • Adriana Macaria Macias-Lamas

A solid-phase extraction (SPE) process, followed by an HPLC-DAD method, was developed and validated to quantify short-chain fatty acids (SCFAs) and applied to analyze chicken feces samples. This study aimed to report the use of the STRATATM-X-A 96 We...

  • Article
  • Open Access
3,888 Views
11 Pages

Categorization of Marijuana Suspected Policies’ Seizures in Southeast Serbia According to Cannabinoids Content

  • Emilija Kostic,
  • Mirjana Djukic,
  • Aleksandra Antovic,
  • Miodrag Zdravkovic,
  • Miroslav Milic,
  • Ivan Stojanovic,
  • Stevan Todorovic and
  • Maja Vujovic

Background: The cannabis plant or marijuana has been used since ancient times for different purposes. An increase in the content of THC in cannabis has been observed worldwide, whereas the CBD content is dropping. This study’s main goal was to...

  • Protocol
  • Open Access
4,778 Views
15 Pages

In the last decade, research has shown that most diseases are associated with organelle dysfunction in which metabolites play a crucial role or indicate specific processes. Peroxisomes are cellular organelles attracting an increasing amount of attent...

  • Feature Paper
  • Article
  • Open Access
3 Citations
2,809 Views
18 Pages

Separation of Co(II) and Ni(II) Using an Analog of Glycine-Betaine Based on Task-Specific Ionic Liquids

  • Lamia Boulafrouh,
  • Stéphanie Boudesocque,
  • Aminou Mohamadou and
  • Laurent Dupont

A series of salts based on ethyl ester glycine-betaine derivatives, viz tri(n-pentyl)[2-ethoxy-2-oxoethyl]ammonium bromide, have been synthesized. These cations generate hydrophobic ionic liquids (ILs) with bis(trifluoromethylsulfonyl)imide (Tf2N&min...

  • Article
  • Open Access
7 Citations
3,602 Views
12 Pages

In this study, the facile and sustainable synthesis of highly microporous carbons is explored to reduce the extensive use of harsh activating agents and solvents. The role of potassium citrate (PC) as a greener activating agent in addition to the con...

  • Article
  • Open Access
13 Citations
2,708 Views
14 Pages

Fenebrutinib (GDC-0853; FNB) is an oral small molecule that was developed by Roche Pharmaceuticals to slow multiple sclerosis progression. FNB is a reversible bruton tyrosine kinase (BTK) inhibitor, which showed the maximum potency of BTK inhibitors...

  • Article
  • Open Access
11 Citations
7,253 Views
14 Pages

Swietenia mahagoni Leaves Extract: Antifungal, Insecticidal, and Phytochemical Analysis

  • Wael M. Khamis,
  • Ahmed A. Heflish,
  • Sarah El-Messeiry,
  • Said I. Behiry,
  • Abdulaziz A. Al-Askar,
  • Yiming Su,
  • Ahmed Abdelkhalek and
  • Mohamed K. Gaber

In this study, we investigated the antifungal properties of an acetone extract derived from the leaves of Swietenia mahagoni (SMAL) against two isolated fungi, Fusarium equiseti (OQ820153) and Rhizoctonia solani (OQ820152), from rice sheath. The extr...

  • Review
  • Open Access
27 Citations
6,393 Views
32 Pages

Recent Advances in Using Adsorbent Derived from Agricultural Waste for Antibiotics and Non-Steroidal Anti-Inflammatory Wastewater Treatment: A Review

  • Abu Hassan Nordin,
  • Abdul Samad Norfarhana,
  • Siti Fadilla Md Noor,
  • Syafikah Huda Paiman,
  • Muhammad Luqman Nordin,
  • Siti Muhamad Nur Husna,
  • Rushdan Ahmad Ilyas,
  • Norzita Ngadi,
  • Aznizam Abu Bakar and
  • Walid Nabgan
  • + 3 authors

Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are among the top pharmaceutical contaminants that have been often found in the aquatic environment. The presence of these contaminants in the aquatic environment is of great concern sinc...

  • Article
  • Open Access
3 Citations
2,549 Views
13 Pages

Separation of Zinc from Zinc Ferrite by Magnetization Roasting and Ammonia Leaching

  • Zeqiang Xie,
  • Tao Jiang,
  • Yufeng Guo,
  • Shuai Wang,
  • Feng Chen,
  • Lingzhi Yang and
  • Ganghua Fu

Zinc ferrite can be found in zinc-bearing dust in ironmaking and steelmaking. It is difficult to be recovered due to its stable properties. The magnetization roasting and ammonia leaching method were used to separate iron and zinc from zinc ferrite i...

  • Article
  • Open Access
3 Citations
3,333 Views
12 Pages

Fractionation of Marigold Waxy Extract Using Supercritical CO2

  • Alessandra Zanotti,
  • Lucia Baldino,
  • Mariarosa Scognamiglio and
  • Ernesto Reverchon

Marigold oil is a product of great industrial interest thanks to its wide range of medicinal and wound-healing properties. In this work, supercritical carbon dioxide was used to recover marigold essential oil from the hexane solvent extract of marigo...

  • Article
  • Open Access
2 Citations
2,283 Views
19 Pages

The potential utilization of magnetic effects in gas particle separation is a current subject of research. This paper demonstrates for the first time that a single magnetizable filter fiber can be deflected by a magnetically induced excitation for a...

  • Article
  • Open Access
3 Citations
1,990 Views
15 Pages

The valorization of natural polymeric substrates has increased due to their uses and applications in several fields. The existence of many functional groups in their chemical structures allows them to be easily subjected to chemical modifications. Th...

  • Article
  • Open Access
2 Citations
4,457 Views
17 Pages

Development and Validation of Analytical Method Using Gas Chromatography with Triple Quadrupole Mass Spectrometry for the Detection of Alkyl Halides as Potential Genotoxic Impurities in Posaconazole

  • Hari Naga Prasada Reddy Chittireddy,
  • J. V. Shanmukha Kumar,
  • Anuradha Bhimireddy,
  • Mohammed Rafi Shaik,
  • Mujeeb Khan,
  • Merajuddin Khan,
  • Tae Hwan Oh and
  • Baji Shaik

Effective risk management and control methods for potentially genotoxic impurities (PGIs), including alkyl halides, are of significant importance in the medicinal (pharmaceutical) sector. The three alkyl halides in posaconazole are PGIs. The detectio...

  • Article
  • Open Access
2,056 Views
17 Pages

Study on Homogeneous Reduction Technology in Gas Samples for Oil and Gas Loss

  • Lu Fan,
  • Yu Yue,
  • Honglin Song,
  • Xiaohan Zhang,
  • Xinyun Hu and
  • Yongshou Dai

The process of storing oil depots and combined station tanks is affected by factors such as process technology, equipment, and management methods. Inevitably, some heavy hydrocarbon components will condense. According to the available literature, the...

  • Article
  • Open Access
3 Citations
2,941 Views
15 Pages

Sex Differentiation from Human Scent Chemical Analysis

  • Petra Pojmanová,
  • Nikola Ladislavová,
  • Veronika Škeříková,
  • Jaromír Kukal and
  • Štěpán Urban

Human scent traces are often the only pieces of evidence providing information about individuals that were present at a crime scene. In this study, the possibility of sex differentiation using detailed chemical analyses of human scent samples for for...

  • Article
  • Open Access
9 Citations
2,239 Views
11 Pages

Since active pharmaceutical ingredients (APIs) are directly related to human health, monitoring and quantifying them in the environment is a crucial and challenging issue. Using capillary-zone electrophoresis (CZE), four frequently used fluoroquinolo...

  • Article
  • Open Access
4 Citations
3,162 Views
17 Pages

The potential development of a rapid and highly sensitive breast cancer (BC) diagnostic method has been increasingly investigated by many researchers in order to significantly improve the diagnosis of this disease that affects millions of women world...

  • Article
  • Open Access
19 Citations
4,490 Views
23 Pages

The recovery of bioactive products with green processes is a critical topic for the research and industry fields. In this work, the application of solid–liquid (SLE), microwave-assisted extraction (MAE) with aq. ethanol 90% v/v and supercritica...

  • Article
  • Open Access
7 Citations
3,410 Views
24 Pages

Removal of Ni(II) and Cu(II) in Aqueous Solutions Using Treated Water Hyacinth (Eichhornia crassipes) as Bioadsorbent

  • Carlos González-Tavares,
  • Mercedes Salazar-Hernández,
  • Alfonso Talavera-López,
  • Juan Manuel Salgado-Román,
  • Rosa Hernández-Soto and
  • José A. Hernández

Phytoremediation consists of taking advantage of the capacity of certain plants to absorb, accumulate, or metabolize contaminants. In this study, Eichornia crassipes (water lily) treated with water (WLW) and NaOH (WLN) was investigated as an adsorben...

  • Article
  • Open Access
9 Citations
2,062 Views
13 Pages

A combined preparation of SO2 and recovery of solid products was investigated as a hazard-free method to use coke as a reducer to treat electrolytic manganese residue (EMR) at high temperature. In this study, the response surface prediction and therm...

  • Article
  • Open Access
9 Citations
2,340 Views
16 Pages

Geographical Origin Authentication of Edible Chrysanthemum morifolium Ramat. (Hangbaiju) Using Stable Isotopes

  • Hanyi Mei,
  • Jing Nie,
  • Shu Wang,
  • Yongzhi Zhang,
  • Chunlin Li,
  • Shengzhi Shao,
  • Shanshan Shao,
  • Karyne M. Rogers and
  • Yuwei Yuan

Chrysanthemum morifolium Ramat., known as Hangbaiju (HBJ), is a high-value edible, medicinal product where the flowers are infused in hot water and drunk as tea. Its quality and efficacy are closely related to its geographical origin. Consequently, i...

  • Article
  • Open Access
8 Citations
2,984 Views
19 Pages

The study of the liquid–liquid extraction of gadolinium (Gd(III) ion) with a chelating compound, 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HP), and the determination of the process parameters are presented by employing two ionic liquids, n...

  • Article
  • Open Access
2 Citations
2,242 Views
14 Pages

Effect of Na+ on the Adsorption Behavior of Polystyrene Nanoparticles onto Coal and Quartz Surfaces

  • Yujin Sun,
  • Ning Jiang,
  • Xianshu Dong,
  • Yuping Fan,
  • Maoqing Yang,
  • Peng Xiong and
  • Yuran Chen

The recovery of difficult-to-float coal using traditional nonpolar hydrocarbon oil collectors can be challenging, particularly for low-rank or oxidized coal. Thus, there is a need for more efficient flotation agents. Nanoparticle flotation collector...

  • Article
  • Open Access
3 Citations
4,301 Views
27 Pages

Cyclone separators are used in multi-phase flows for phase separation or classification. Pressure drop and separation efficiency are essential parameters for determining the performance of a cyclone separator, and critical diameter is an important pa...

  • Article
  • Open Access
21 Citations
6,361 Views
14 Pages

Greenness Assessment of HPLC Analytical Methods with Common Detectors for Assay of Paracetamol and Related Materials in Drug Products and Biological Fluids

  • Ibrahim A. Naguib,
  • Meral Majed,
  • Maram Albogami,
  • Maram Alshehri,
  • Aseel Bukhari,
  • Hadeel Alshabani,
  • Izzeddin Alsalahat and
  • Heba-Alla H. Abd-ElSalam

Paracetamol is one of the most widely consumed analgesic and antipyretic medications worldwide. It is frequently analyzed in many quality control (QC) laboratories in pharmaceutical companies, either in raw materials or drug products. It was reported...

  • Article
  • Open Access
4 Citations
6,379 Views
11 Pages

Because of its greater binding affinity and longer half-life than native glucagon-like peptide-1 (GLP-1), the GLP-1 receptor agonist lixisenatide is commonly used to treat type 2 diabetes mellitus. This study aimed to establish a simple and robust li...

  • Article
  • Open Access
26 Citations
4,020 Views
19 Pages

Reports related to incidences of drug facilitated crimes (DFCs) have notably increased in recently. In such cases, victims report being assaulted or robbed while under the influence of drugs. Lorazepam (LZ) is frequently used in DFCs as it can easily...

  • Article
  • Open Access
3 Citations
4,491 Views
15 Pages

Commonly used to treat mood disorders, St. John’s Wort (Hypericum perforatum) is a popular herb in the natural health products industry. The potency of its active ingredients can be determined using a number of different analytical methods, but...

  • Article
  • Open Access
2 Citations
1,672 Views
13 Pages

(1) Background: This research work proposes the ‘passive’ biosorption study of Orange 16 dye onto residual Lactobacillus sp. biomass immobilized in sodium alginate using an experimental modeling design. (2) Methods: It was applied the bat...

  • Article
  • Open Access
20 Citations
2,449 Views
17 Pages

Gilteritinib (Xospata®) is a tyrosine kinase inhibitor (TKI) that works by inhibiting numerous receptor tyrosine kinases, involving AXL and FMS-like tyrosine kinase 3 (FLT3). Gilteritinib (GTB) was approved (28 November 2018) by the USFDA for the...

  • Article
  • Open Access
2 Citations
3,045 Views
12 Pages

(1) Background: The concentration of amisulpride, an atypical antipsychotic drug, is most often determined in the blood, with many inconveniences. An alternative may be to use saliva as a diagnostic material for this purpose. The development of a met...

  • Article
  • Open Access
6 Citations
3,346 Views
18 Pages

This study developed a simple, rapid, reproducible, and analytical method using liquid chromatography and electrospray ionization (ESI) with tandem mass spectrometry (LC-MS/MS) to simultaneously quantify pentoxifylline (PTX), its pharmacological acti...

  • Article
  • Open Access
12 Citations
7,544 Views
12 Pages

Improved Flotation of Fine Flake Graphite Using a Modified Thickening Process

  • Ziming Peng,
  • Dianshun Li,
  • Wenjie Fang,
  • Juan Zhang,
  • Rongyan Zhang,
  • Yangshuai Qiu and
  • Kangkang Sun

Natural graphite ores are usually upgraded by froth flotation. However, complex processes with multistage grinding and flotation are required to achieve decent liberation and separation of graphite and gangue minerals. This study reports a short and...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,057 Views
15 Pages

Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

  • Anna Cazanevscaia Busuioc,
  • Giorgiana Valentina Costea,
  • Andreea Veronica Dediu Botezatu,
  • Bianca Furdui and
  • Rodica Mihaela Dinica

To identify healthy, nutritious, and sustainable plant-based products rich in biologically active compounds, this present study was conducted, and the phytochemical composition and biological properties of the hydroethanolic ultrasound-assisted extra...

  • Article
  • Open Access
14 Citations
5,229 Views
14 Pages

The use of hollow-fiber liquid-phase microextraction (HF-LPME) is very promising for the clean-up, enrichment, and analysis of chlorophenoxyacetic acid herbicides and their metabolites from environmental and biological samples. An on-line methodology...

  • Article
  • Open Access
15 Citations
4,563 Views
17 Pages

Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

  • Jiwei Yang,
  • Zhi Yan,
  • Lingna Li,
  • Lifen Zhang,
  • Mengjian Zhao,
  • Huixiang Yi,
  • Ziying Wang,
  • Gang Li,
  • Zhenhua Wang and
  • Chengjun Ma
  • + 1 author

Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and util...

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Separations - ISSN 2297-8739