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Dermatopathology, Volume 11, Issue 1

March 2024 - 13 articles

Cover Story: Galli–Galli disease is a rare autosomal dominant genodermatosis typically presenting with erythematous macules, papules, and reticulated hyperpigmentation of the flexural areas. A distinct atypical variant is characterized by brown macules on the trunk and extremities without the characteristic reticulated hyperpigmentation. This review examines cases since the disease was first described and summarizes current knowledge regarding its etiology, clinical presentation, histopathology, diagnosis, and treatment. We review the genetic, histopathologic, and clinical similarities between Galli–Galli disease and Dowling–Degos disease, another rare genodermatosis, focusing on the common mutations in KRT5 and POGLUT1. We support the hypothesis that the two diseases may be different phenotypic expressions of the same pathological condition, although traditionally recognized as separate entities. View this paper
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Articles (13)

  • Article
  • Open Access
5,313 Views
12 Pages

(1) Background: Various cutaneous adverse drug reactions (ADRs) are observed with the implementation of mRNA COVID-19 vaccines. To gain insight into the clinicopathologic features, we analyzed the correlation of histological and clinical data in 48 p...

  • Case Report
  • Open Access
1 Citations
2,466 Views
5 Pages

This case report describes a case of a patient with MUTYH-associated polyposis (MAP), who presented with multiple sebaceomas in a Muir–Torre-like phenotype. MAP is caused by mutations in MUTYH, a base excision repair gene responsible for detect...

  • Review
  • Open Access
7 Citations
4,435 Views
12 Pages

Kinase Fusions in Spitz Melanocytic Tumors: The Past, the Present, and the Future

  • Maged Daruish,
  • Francesca Ambrogio,
  • Anna Colagrande,
  • Andrea Marzullo,
  • Rita Alaggio,
  • Irma Trilli,
  • Giuseppe Ingravallo and
  • Gerardo Cazzato

In recent years, particular interest has developed in molecular biology applied to the field of dermatopathology, with a focus on nevi of the Spitz spectrum. From 2014 onwards, an increasing number of papers have been published to classify, stratify,...

  • Review
  • Open Access
15 Citations
4,211 Views
11 Pages

Skin and Syntax: Large Language Models in Dermatopathology

  • Asghar Shah,
  • Samer Wahood,
  • Dorra Guermazi,
  • Candice E. Brem and
  • Elie Saliba

This literature review introduces the integration of Large Language Models (LLMs) in the field of dermatopathology, outlining their potential benefits, challenges, and prospects. It discusses the changing landscape of dermatopathology with the emerge...

  • Review
  • Open Access
2 Citations
4,790 Views
23 Pages

Galli–Galli Disease: A Comprehensive Literature Review

  • Andrea Michelerio,
  • Antonio Greco,
  • Dario Tomasini and
  • Carlo Tomasini

Galli–Galli disease (GGD) is a rare genodermatosis that exhibits autosomal dominant inheritance with variable penetrance. GGD typically manifests with erythematous macules, papules, and reticulate hyperpigmentation in flexural areas. A distinct...

  • Review
  • Open Access
8 Citations
14,013 Views
17 Pages

The Histopathology of Leg Ulcers

  • Amun Georg Hofmann,
  • Julia Deinsberger,
  • André Oszwald and
  • Benedikt Weber

Ulcerations of the lower extremities are a frequently encountered problem in clinical practice and are of significant interest in public health due to the high prevalence of underlying pathologies, including chronic venous disease, diabetes and perip...

  • Review
  • Open Access
7 Citations
6,987 Views
10 Pages

Direct immunofluorescence is a vital diagnostic test for assessing vesiculobullous disorders, vasculitides, and connective tissue diseases. It is a robust and valuable technique that offers essential diagnostic information for many critical dermatose...

  • Review
  • Open Access
3 Citations
5,296 Views
26 Pages

Over the past decade, molecular and genomic discoveries have experienced unprecedented growth, fundamentally reshaping our comprehension of melanocytic tumors. This review comprises three main sections. The first part gives an overview of the current...

  • Case Report
  • Open Access
2 Citations
4,230 Views
7 Pages

Giant Folliculosebaceous Cystic Hamartoma of the Face

  • Ramona Tasar,
  • Melanie Peckruhn and
  • Jörg Tittelbach

Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of clustered...

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Dermatopathology - ISSN 2296-3529