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Dermatopathology, Volume 10, Issue 4

December 2023 - 3 articles

Cover Story: Dermatomyositis is an immune-mediated myopathy with cutaneous and systemic manifestations. The classic histopathological findings include vacuolar interface changes with mucin deposition and a predominantly lymphocytic infiltrate. Although eosinophils have traditionally been considered rare in skin biopsies of patients with autoimmune connective tissue diseases, recent studies suggest that tissue eosinophils may be more prevalent than previously thought. In this case report, we present a case of dermatomyositis characterized by intensely pruritic papules and plaques, where the presence of tissue eosinophils on histopathology initially posed a diagnostic challenge. This case highlights the importance of not relying solely on tissue eosinophilia as an exclusion criterion in diagnosing dermatomyositis. View this paper

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Articles (3)

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Case Report

1 Citations

5,104 Views

8 Pages

Dermatomyositis with Eosinophils

Isabella I. Sanchez,
Henry O. Herrera,
Ashley Elsensohn,
Bonnie A. Lee and
Christina N. Kraus

Dermatopathology2023, 10(4), 310-317;https://doi.org/10.3390/dermatopathology10040039

21 November 2023

Dermatomyositis is an idiopathic inflammatory myopathy that often presents with symmetric proximal skeletal muscle weakness and characteristic skin findings. Typical skin biopsy findings include vacuolar changes of the basal layer, increased dermal m...

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Communication

3 Citations

2,471 Views

7 Pages

Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides

Haiming Tang,
Kristin J. Rybski,
Yi Luan and
Bruce R. Smoller

Dermatopathology2023, 10(4), 303-309;https://doi.org/10.3390/dermatopathology10040038

23 October 2023

Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and...

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Communication

5 Citations

3,745 Views

16 Pages

The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging

Keiichi Hiramoto,
Sayaka Kubo,
Keiko Tsuji,
Daijiro Sugiyama,
Yasutaka Iizuka and
Hideo Hamano

Dermatopathology2023, 10(4), 287-302;https://doi.org/10.3390/dermatopathology10040037

28 September 2023

Background: Lactic acid bacteria consumption serves several health benefits to humans. However, their effect on natural skin aging is still unclear. Methods: This study examined the effects of skin naturalization (particularly skin drying) by adminis...

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Dermatopathology - ISSN 2296-3529

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