Next Article in Journal
Challenges in Caring for Linguistic Minorities in the Pediatric Population
Previous Article in Journal
The Use of Age Assessment in the Context of Child Migration: Imprecise, Inaccurate, Inconclusive and Endangers Children’s Rights
Previous Article in Special Issue
Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
Open AccessReview

Current Management of Pleuropulmonary Blastoma: A Surgical Perspective

1
Southern Illinois University School of Medicine, Division of Surgery, Department of General Surgery, Springfield, IL 62702, USA
2
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Children’s Hospital of Michigan, Detroit, MI 48201, USA
3
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
4
Department of Surgery, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
5
Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA
*
Authors to whom correspondence should be addressed.
Children 2019, 6(8), 86; https://doi.org/10.3390/children6080086
Received: 18 June 2019 / Revised: 9 July 2019 / Accepted: 20 July 2019 / Published: 25 July 2019
(This article belongs to the Special Issue Pediatric Surgical Oncology)
Pleuropulmonary blastomas (PPB) are pediatric, embryonal cancers of the lung parenchyma and pleural surfaces and are among the most common DICER1—related disorders. These tumors undergo evolution through several forms, allowing division into types I, Ir, II, and III, with correlates to the age of diagnosis and prognosis. We sought to provide a comprehensive review of the relevant literature describing the characteristics of these tumors and their multidisciplinary treatment, with an emphasis on surgical management. We describe the complementary roles of chemotherapy and surgery in the successful management of this disease. We discuss the timing of surgery and options for surgical approaches. We address the differentiation of PPB from congenital pulmonary airway malformation and the role of DICER1 testing for children with pulmonary cysts. View Full-Text
Keywords: pleuropulmonary blastoma; congenital pulmonary airway malformations; congenital cystic adenomatoid malformations; DICER1; multidisciplinary management; surgery pleuropulmonary blastoma; congenital pulmonary airway malformations; congenital cystic adenomatoid malformations; DICER1; multidisciplinary management; surgery
Show Figures

Figure 1

MDPI and ACS Style

Knight, S.; Knight, T.; Khan, A.; Murphy, A.J. Current Management of Pleuropulmonary Blastoma: A Surgical Perspective. Children 2019, 6, 86.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop