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Open AccessCase Report

Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for Tooth Extraction in Patients under Bisphosphonate Therapy: A Case Report

Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, University of Milan, Via Beldiletto 1, 20142 Milano, Italy
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Biomedicines 2019, 7(4), 89; https://doi.org/10.3390/biomedicines7040089
Received: 25 September 2019 / Revised: 31 October 2019 / Accepted: 2 November 2019 / Published: 10 November 2019
Tooth extraction in patients treated with bisphosphonates (BPs) for osteoporosis or cancer exposes the patient to the risk of osteonecrosis of the jaw. An autologous membrane using platelet-rich fibrin (PRF) is an innovative technique to promote wound healing, which allows obtaining a hermetic closure of the post-extractive surgical site without the need of mucoperiosteal flaps or periosteal releasing incisions. Here, we report the case of a 70-year-old woman, in therapy with alendronate for 12 years, requiring the upper right premolar extraction because of a crown fracture. After the tooth extraction performed under antiseptic and antibiotic coverage, the PRF autologous membrane was placed on the surgical wound to close completely the post-extraction site. Follow-up visits were carried out after one, two, four weeks and two months from the intervention. The complete re-epithelization of the wound was observed without signs of infection. The use of PRF for the closure of post-extraction sockets in patients taking BPs appears to be a promising alternative to the more invasive surgical procedures. Future clinical trials will be pivotal in elucidating the effectiveness of PRF to prevent BP-related osteonecrosis after tooth extraction. View Full-Text
Keywords: oral medicine; oral surgery; bisphosphonates; platelet-rich fibrin; osteonecrosis oral medicine; oral surgery; bisphosphonates; platelet-rich fibrin; osteonecrosis
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Pispero, A.; Bancora, I.; Khalil, A.; Scarnò, D.; Varoni, E.M. Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for Tooth Extraction in Patients under Bisphosphonate Therapy: A Case Report. Biomedicines 2019, 7, 89.

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