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Biomedicines, Volume 11, Issue 10

October 2023 - 278 articles

Cover Story: Understanding the mechanisms governing prolonged drug retention at target sites is vital for enhancing treatment efficacy. In this Special Issue, Sharma et al. investigate the dynamic interaction of epichaperome agents, such as zelavespib and icapamespib, with the target in vivo, unveiling the intricate processes that contribute to their extended retention at the target site and their effectiveness in treating various diseases. The cover highlights the pivotal role of specific binding and stabilization within the epichaperome complex, leading to target disruption. By elucidating these dynamics, this study provides key insights into pharmacological strategies for prolonged drug retention that translate into effective disease control. View this paper
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Articles (278)

  • Article
  • Open Access
2 Citations
2,519 Views
14 Pages

Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation

  • Nikolina Režić Mužinić,
  • Anita Markotić,
  • Sanda Pavelin,
  • Denis Polančec,
  • Maja Buljubašić Šoda,
  • Antonia Bralić,
  • Joško Šoda,
  • Angela Mastelić,
  • Una Mikac and
  • Ana Jerković
  • + 1 author

Expression of CD40 and CD192 markers in different monocyte subpopulations has been reported to be altered in people with MS (pwMS). Also, functional connectivity of the corticospinal motor system pathway alterations has been proved by transcranial ma...

  • Article
  • Open Access
11 Citations
3,009 Views
17 Pages

Transferrin-Modified Triptolide Liposome Targeting Enhances Anti-Hepatocellular Carcinoma Effects

  • Xiaoli Zhao,
  • Yifan Yang,
  • Xuerong Su,
  • Ying Xie,
  • Yiyao Liang,
  • Tong Zhou,
  • Yangqian Wu and
  • Liuqing Di

Triptolide (TP) is an epoxy diterpene lactone compound isolated and purified from the traditional Chinese medicinal plant Tripterygium wilfordii Hook. f., which has been shown to inhibit the proliferation of hepatocellular carcinoma. However, due to...

  • Review
  • Open Access
32 Citations
8,145 Views
15 Pages

Endometriosis-Related Chronic Pelvic Pain

  • Soo Youn Song,
  • Ye Won Jung,
  • WonKyo Shin,
  • Mia Park,
  • Geon Woo Lee,
  • Soohwa Jeong,
  • Sukjeong An,
  • Kyoungmin Kim,
  • Young Bok Ko and
  • Ki Hwan Lee
  • + 3 authors

Endometriosis, which is the presence of endometrial stroma and glands outside the uterus, is one of the most frequently diagnosed gynecologic diseases in reproductive women. Patients with endometriosis suffer from various pain symptoms such as dysmen...

  • Article
  • Open Access
3 Citations
2,662 Views
15 Pages

Fibromyalgia (FM) is a condition characterized by musculoskeletal pain and multiple comorbidities. Our study aimed to identify four clusters of FM patients according to their core clinical symptoms and neuropsychological comorbidities to identify pos...

  • Article
  • Open Access
3 Citations
1,951 Views
15 Pages

Predictive Value of Fatty Liver Index for Long-Term Cardiovascular Events in Patients Receiving Liver Transplantation: The COLT Study

  • Alfredo Caturano,
  • Gaetana Albanese,
  • Anna Di Martino,
  • Carmine Coppola,
  • Vincenzo Russo,
  • Raffaele Galiero,
  • Luca Rinaldi,
  • Marcellino Monda,
  • Raffaele Marfella and
  • Ferdinando Carlo Sasso
  • + 1 author

Background and aims: Cardiovascular disease (CVD) is the leading cause of early mortality in orthotopic liver transplantation (OLT) patients. The fatty liver index (FLI) is strongly associated with carotid and coronary atherosclerosis, as well as car...

  • Review
  • Open Access
6 Citations
3,333 Views
17 Pages

Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine

  • Marcello Bergonzini,
  • Francesco Loreni,
  • Antonio Lio,
  • Marco Russo,
  • Guglielmo Saitto,
  • Antonio Cammardella,
  • Francesco Irace,
  • Corrado Tramontin,
  • Massimo Chello and
  • Mario Lusini
  • + 4 authors

Epigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlig...

  • Article
  • Open Access
9 Citations
4,085 Views
29 Pages

Background: Cerebral microbleeds (CMBs), a notable neuroimaging finding often associated with cerebral microangiopathy, demonstrate a heightened prevalence in patients diagnosed with acute ischemic stroke (AIS), which is in turn linked to less favour...

  • Article
  • Open Access
3 Citations
4,283 Views
17 Pages

Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models

  • Melina J. Lim,
  • Suelen L. Boschen,
  • Aishe Kurti,
  • Monica Castanedes Casey,
  • Virginia R. Phillips,
  • John D. Fryer,
  • Dennis Dickson,
  • Karen R. Jansen-West,
  • Leonard Petrucelli and
  • Marion Delenclos
  • + 1 author

Lewy body dementia (LBD) is an often misdiagnosed and mistreated neurodegenerative disorder clinically characterized by the emergence of neuropsychiatric symptoms followed by motor impairment. LBD falls within an undefined range between Alzheimer&rsq...

  • Article
  • Open Access
2 Citations
2,347 Views
15 Pages

Clinical Outcomes of Patients with Chronic Neuropathic Form of Gaucher Disease in the Spanish Real-World Setting: A Retrospective Study

  • Sinziana Stanescu,
  • Patricia Correcher Medina,
  • Francisco J. del Castillo,
  • Olga Alonso Luengo,
  • Luis Maria Arto Millan,
  • Amaya Belanger Quintana,
  • Maria Camprodon Gomez,
  • Lydia Diez Langhetée,
  • Oscar Garcia Campos and
  • Ana Matas Garcia
  • + 5 authors

This was a retrospective, multicenter study that aimed to report the characteristics of type 3 Gaucher disease (GD3) patients in Spain, including the genotype, phenotype, therapeutic options, and treatment responses. A total of 19 patients with GD3 f...

  • Article
  • Open Access
5 Citations
2,301 Views
16 Pages

To date, insufficient investigation has been carried out on the biocompatibility of synthetic bioactive bone substitute materials after traumatically induced bone fractures in clinical conditions. This study encompasses the safety, resorption, healin...

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Biomedicines - ISSN 2227-9059Creative Common CC BY license