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Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD)

Department of Orthodontics, College of Dentistry, Karachi Medical and Dental College, Karachi 74700, Pakistan
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia
Department of Restorative Dentistry, Dar Al Uloom University, Riyadh 13314, Saudia Arabia
Department of Preventive Dental Sciences, Dar Al Uloom University, Riyadh 13314, Saudia Arabia
Department of Oral Medicine, Islamabad Dental Hospital (IDH), Islamabad 44000, Pakistan
Department of Oral Pathology, College of Dentistry, Baqai University, Karachi 74600, Pakistan
Author to whom correspondence should be addressed.
Proteomes 2017, 5(3), 21;
Received: 4 June 2017 / Revised: 3 August 2017 / Accepted: 5 August 2017 / Published: 7 August 2017
(This article belongs to the Special Issue Proteomic Biomarkers in Human Diseases)
PDF [993 KB, uploaded 7 August 2017]


Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below. View Full-Text
Keywords: saliva; proteins; biomarkers; cardiovascular diseases and diagnosis saliva; proteins; biomarkers; cardiovascular diseases and diagnosis

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Abdul Rehman, S.; Khurshid, Z.; Hussain Niazi, F.; Naseem, M.; Al Waddani, H.; Sahibzada, H.A.; Sannam Khan, R. Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD). Proteomes 2017, 5, 21.

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