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Journal of Developmental Biology, Volume 13, Issue 4

December 2025 - 12 articles

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Articles (12)

  • Review
  • Open Access
207 Views
21 Pages

Pathophysiology and Management of Placenta Accreta Spectrum

  • Lana Shteynman,
  • Genevieve Monanian,
  • Gilberto Torres,
  • Giancarlo Sabetta,
  • Deborah M. Li,
  • Zhaosheng Jin,
  • Tiffany Angelo,
  • Bahaa E. Daoud and
  • Morgane Factor

10 December 2025

Placenta Accreta Spectrum (PAS) disorders, including placenta accreta, increta, and percreta, are serious obstetric conditions characterized by abnormal placental adherence to the uterine wall. With increasing incidence, PAS poses significant risks,...

  • Systematic Review
  • Open Access
166 Views
17 Pages

Cardiac Aftermath of Gestational Diabetes—From Intrauterine Impact to Lifelong Complications: A Systematic Review

  • Sophia Tsokkou,
  • Ioannis Konstantinidis,
  • Antonios Keramas,
  • Vasileios Anastasiou,
  • Alkis Matsas,
  • Maria Florou,
  • Alexandra Arvanitaki,
  • Emmanouela Peteinidou,
  • Theodoros Karamitsos and
  • George Giannakoulas
  • + 4 authors

8 December 2025

Background. Gestational diabetes mellitus (GDM) induces maternal hyperglycemia, which may alter fetal cardiac structure and function, increasing short- and long-term cardiovascular risks. Purpose. To systematically review the evidence on the fetal ca...

  • Review
  • Open Access
359 Views
20 Pages

2 December 2025

Observations of the processes of oogenesis, fertilization, and the earliest embryonic development have given us the opportunity to estimate the importance of chromosomal distribution errors for the success of mammalian reproduction. It is now known t...

  • Article
  • Open Access
439 Views
15 Pages

Dynamic Alterations in Testicular Autophagy in Prepubertal Mice

  • Dong Zhang,
  • Xiaoyun Pang,
  • Zhenxing Yan,
  • Weitao Dong,
  • Zihao Fang,
  • Jincheng Yang,
  • Yanyan Wang,
  • Li Xue,
  • Jiahao Zhang and
  • Chen Xue
  • + 3 authors

18 November 2025

Autophagy has a potential regulatory effect on spermatogenesis and testicular development. Dynamic alterations in the testicular autophagy of prepubertal mice were analyzed, and the relationship between autophagy levels and testicular development was...

  • Article
  • Open Access
456 Views
14 Pages

Cloned Pig Fetuses Have a High Placental Lysophosphatidylcholine Level That Inhibits Trophoblast Cell Activity

  • Junkun Lai,
  • Xiaoyu Gao,
  • Guke Zhang,
  • Xiao Wu,
  • Yiqian Zhang,
  • Shunbo Wang,
  • Zhenfang Wu,
  • Zicong Li and
  • Zheng Xu

12 November 2025

Somatic cell nuclear transfer (SCNT) or cloning technology is widely used in agriculture and biomedicine. However, the application of this technology is limited by the low developmental competence of cloned embryos or fetuses, which frequently exhibi...

  • Review
  • Open Access
1,371 Views
20 Pages

Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders

  • Aki Shigenaka,
  • Eri Nitta,
  • Tadashi Nakagawa,
  • Makiko Nakagawa and
  • Toru Hosoi

7 November 2025

Neurodevelopmental disorders (NDDs), including autism spectrum disorder, intellectual disability, and attention deficit hyperactivity disorder, are increasingly recognized as disorders of early brain construction arising from defects in neural stem a...

  • Review
  • Open Access
805 Views
19 Pages

Recapitulating Liver Embryology—Lessons to Be Learned for Liver Diseases

  • Rui Caetano Oliveira,
  • Sandra Ferreira,
  • Isabel Gonçalves and
  • Maria Fátima Martins

4 November 2025

Despite looking monotonous, liver histology represents a highly complex structure of hepatocytes, bile ducts and vessels. This complex interaction and development originate in embryology and remain in adult life. In this manuscript, we highlight the...

  • Article
  • Open Access
570 Views
19 Pages

Activity-Dependent Increases in Quantal Size at the Drosophila NMJ

  • Andrew S. Powers,
  • Petar Gajic,
  • Ethan Rittereiser,
  • Kavindra Dasrat and
  • Gregory A. Lnenicka

28 October 2025

We examined whether an increase in synaptic activity resulted in an increase in quantal size at the neuromuscular junction (NMJ) of third-instar Drosophila larvae. Spontaneous miniature excitatory postsynaptic currents (mEPSCs) or miniature excitator...

  • Article
  • Open Access
731 Views
18 Pages

15 October 2025

Estrogen metabolites (EMs) play a local regulatory role in mammalian ovarian function. Among them, 2-hydroxyestradiol (2-OHE2) exerts dose-dependent effects on reproductive physiology, supporting either normal ovarian processes or contributing to pat...

  • Review
  • Open Access
1,246 Views
24 Pages

8 October 2025

Wnt signaling is an ancient developmental mechanism that drives the initial specification and patterning of the primary axis in many metazoan embryos. Yet, it is unclear how exactly the various Wnt components interact in most Wnt-mediated development...

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J. Dev. Biol. - ISSN 2221-3759