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Open AccessReview

Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review

1
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
2
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
3
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(10), 1397; https://doi.org/10.3390/biom10101397
Received: 30 July 2020 / Revised: 29 August 2020 / Accepted: 2 September 2020 / Published: 30 September 2020
(This article belongs to the Collection Pharmacology of Medicinal Plants)
Hydroxytyrosol (HT) is an essential molecule isolated from the phenolic fraction of olive (Olea europaea). HT has been implicated for its health-stimulating effect mainly due to its antioxidative capacity. The current review summarises and discusses the available evidence, related to HT activities in wound healing enhancement. The literature search of related articles published within the year 2010 to 2020 was conducted using Medline via Ebscohost, Scopus, and Google Scholar databases. Studies were limited to in vitro research regarding the role of HT in wound closure, including anti-inflammation, antimicrobial, antioxidative, and its direct effect to the cells involved in wound healing. The literature search revealed 7136 potentially relevant records were obtained from the database search. Through the screening process, 13 relevant in vitro studies investigating the role of HT in wound repair were included. The included studies reported a proangiogenic, antioxidative, antiaging, anti-inflammatory and antimicrobial effect of HT. The current in vitro evidence-based review highlights the cellular and molecular action of HT in influencing positive outcomes toward wound healing. Based on this evidence, HT is a highly recommended bioactive compound to be used as a pharmaceutical product for wound care applications. View Full-Text
Keywords: hydroxytyrosol; wound healing; cellular; antioxidant; anti-inflammatory; antimicrobial hydroxytyrosol; wound healing; cellular; antioxidant; anti-inflammatory; antimicrobial
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MDPI and ACS Style

Utami, N.D.; Nordin, A.; Katas, H.; Bt Hj Idrus, R.; Fauzi, M.B. Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review. Biomolecules 2020, 10, 1397. https://doi.org/10.3390/biom10101397

AMA Style

Utami ND, Nordin A, Katas H, Bt Hj Idrus R, Fauzi MB. Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review. Biomolecules. 2020; 10(10):1397. https://doi.org/10.3390/biom10101397

Chicago/Turabian Style

Utami, Nike D.; Nordin, Abid; Katas, Haliza; Bt Hj Idrus, Ruszymah; Fauzi, Mh B. 2020. "Molecular Action of Hydroxytyrosol in Wound Healing: An In Vitro Evidence-Based Review" Biomolecules 10, no. 10: 1397. https://doi.org/10.3390/biom10101397

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