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Volume 77
Issue 2
10.3797/scipharm.0902-07
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Article

Simultaneous Determination of Epinephrine and Norepinephrine by High Performance Liquid Chromatography

by
Arun MISHRA
,
Adesh UPADHYAY
,
Arjun PATRA
,
Sachin CHAUDHURY
and
Pronobesh CHATTOPADHYAY
*
Cellular and Microbiology Laboratory, College of Pharmacy, IFTM, Lodhipur Rajput - 243112, Moradabad - 244001, Uttar Pradesh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(2), 367-374; https://doi.org/10.3797/scipharm.0902-07
Submission received: 15 February 2009 / Accepted: 2 April 2009 / Published: 4 April 2009
Versions Notes

Abstract

Epinephrine and non-epinephrine are major endogenous catecholamines which are known as neurotransmitter. The plasma levels of catecholamines are significant markers of several neuro-endocrine disorders and autonomic nervous system disorders. A method for the simultaneous quantitation of epinephrine and norepinephrine is described. The related substances are resolved on a Phenomenex ODS analytical column C18 column (150 mm × 4.6 mm, 5 μm) using a mobile phase composed of a mixture of acetic acid and 50mM sodium acetate buffer pH 3.1 (1:99 v/v) at a flow rate of 1 ml/min with UV detector at 285 nm. The method is compatible with HPLC-MS and provides a tool for the control of substandard and counterfeit commercial preparations of epinephrine and norepinephrine.
Keywords: Adrenaline; Noraderaniline; HPLC Adrenaline; Noraderaniline; HPLC

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MDPI and ACS Style

MISHRA, A.; UPADHYAY, A.; PATRA, A.; CHAUDHURY, S.; CHATTOPADHYAY, P. Simultaneous Determination of Epinephrine and Norepinephrine by High Performance Liquid Chromatography. Sci. Pharm. 2009, 77, 367-374. https://doi.org/10.3797/scipharm.0902-07

AMA Style

MISHRA A, UPADHYAY A, PATRA A, CHAUDHURY S, CHATTOPADHYAY P. Simultaneous Determination of Epinephrine and Norepinephrine by High Performance Liquid Chromatography. Scientia Pharmaceutica. 2009; 77(2):367-374. https://doi.org/10.3797/scipharm.0902-07

Chicago/Turabian Style

MISHRA, Arun, Adesh UPADHYAY, Arjun PATRA, Sachin CHAUDHURY, and Pronobesh CHATTOPADHYAY. 2009. "Simultaneous Determination of Epinephrine and Norepinephrine by High Performance Liquid Chromatography" Scientia Pharmaceutica 77, no. 2: 367-374. https://doi.org/10.3797/scipharm.0902-07

APA Style

MISHRA, A., UPADHYAY, A., PATRA, A., CHAUDHURY, S., & CHATTOPADHYAY, P. (2009). Simultaneous Determination of Epinephrine and Norepinephrine by High Performance Liquid Chromatography. Scientia Pharmaceutica, 77(2), 367-374. https://doi.org/10.3797/scipharm.0902-07

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