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Volume 77
Issue 2
10.3797/scipharm.0812-07
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent

by
Amir R. JALILIAN
1,*,
Pegah MEHDIPOUR
2,
Mehdi AKHLAGHI
1,
Hassan YOUSEFNIA
1 and
Kamaledin SHAFAII
1
1
Radiolabeling Lab, Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Moazzen Blvd., Rajaeeshahr, P.O.Box: 31485-498, Karaj, Iran
2
Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(2), 343-354; https://doi.org/10.3797/scipharm.0812-07
Submission received: 5 December 2008 / Accepted: 5 March 2009 / Published: 6 March 2009
Versions Notes

Abstract

[67Ga]labeled 2-acetylpyridine 4,4-dimethylthiosemicarbazone ([67Ga]- [APTSM2]2+) was prepared using freshly prepared [67Ga]GaCl3 and 2-acetylpyridine 4,4-dimethylthiosemicarbazone (APTSM2) for 30 min at 90°C (radiochemical purity: >97% ITLC, >98% HPLC, specific activity: 15–20 Ci/mmol). Stability of the complex was checked in human serum for 37°C. The biodistribution of the labeled compound in vital organs of normal and fibrosarcoma bearing mice were compared with that of free Ga3+ cation up to 24h. Initial SPECT images and biodistribution results showed significant tumor uptake in fibrosarcoma-bearing mice after 2 hour post injection.
Keywords: 67Ga-complexation; Thiosemicarbazone; Biodistribution; SPECT; Fibrosarcoma 67Ga-complexation; Thiosemicarbazone; Biodistribution; SPECT; Fibrosarcoma

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MDPI and ACS Style

JALILIAN, A.R.; MEHDIPOUR, P.; AKHLAGHI, M.; YOUSEFNIA, H.; SHAFAII, K. Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Sci. Pharm. 2009, 77, 343-354. https://doi.org/10.3797/scipharm.0812-07

AMA Style

JALILIAN AR, MEHDIPOUR P, AKHLAGHI M, YOUSEFNIA H, SHAFAII K. Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Scientia Pharmaceutica. 2009; 77(2):343-354. https://doi.org/10.3797/scipharm.0812-07

Chicago/Turabian Style

JALILIAN, Amir R., Pegah MEHDIPOUR, Mehdi AKHLAGHI, Hassan YOUSEFNIA, and Kamaledin SHAFAII. 2009. "Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent" Scientia Pharmaceutica 77, no. 2: 343-354. https://doi.org/10.3797/scipharm.0812-07

APA Style

JALILIAN, A. R., MEHDIPOUR, P., AKHLAGHI, M., YOUSEFNIA, H., & SHAFAII, K. (2009). Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Scientia Pharmaceutica, 77(2), 343-354. https://doi.org/10.3797/scipharm.0812-07

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