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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

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Sci. Pharm., Volume 75, Issue 1 (March 2007) – 4 articles , Pages 1-54

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Open AccessArticle
Antioxidant and Antimicrobial Activities of Hyptis suaveolens Essential Oil
Sci. Pharm. 2007, 75(1), 35-54; https://doi.org/10.3797/scipharm.2007.75.35 - 30 Mar 2007
Cited by 45 | Viewed by 1272
Abstract
The essential oil of Hyptis suaveolens obtained by steam distillation was examined for its antioxidant and antimicrobial activities. The antioxidant activity was determined by means of the DPPH radical scavenging test and ABTS free radical decolorization assay. Results from both methods indicate that [...] Read more.
The essential oil of Hyptis suaveolens obtained by steam distillation was examined for its antioxidant and antimicrobial activities. The antioxidant activity was determined by means of the DPPH radical scavenging test and ABTS free radical decolorization assay. Results from both methods indicate that the antioxidant activity of H. suaveolens oil is time and concentration dependent. The antioxidant potential of H. suaveolens oil determined by the DPPH method expressed as IC50 was 3.72 mg/ml whereas the TEAC value determined by the ABTS assay was 65.02 µM/mg. The antimicrobial activity of the essential oil was assessed by the dilution and well diffusion methods. The results show that the antifungal potential of H. suaveolens oil is more pronounced than its antibacterial properties. Its fungal growth inhibitory activity was dose dependent with a MID value of 1:640. The 20% ethanolic solution of H. suaveolens oil had antifungal power similar to 6% boric acid, 2% benzoic acid, or 5% salicylic acid but higher than 4% phenol. The activity decreased when the oil was stored at high temperature (> 40°C). The results of GC-MS analysis indicated the changes in oil composition which led to the decrease in antifungal activity. Full article
Open AccessArticle
New Compounds from Rhodiola Kirilowii
Sci. Pharm. 2007, 75(1), 29-34; https://doi.org/10.3797/scipharm.2007.75.29 - 30 Mar 2007
Cited by 20 | Viewed by 782
Abstract
Five compounds were isolated from root extracts of Rhodiola kirilowii: arbutin, epigallocatechin gallate, rhodiocyanoside A, fructopyrano-(1-4)-glucopyranose and lotaustralin. The first four compounds were found in this plant for the first time. Lotaustralin, salidroside, daucosterol and tyrosol were already described to be contained. [...] Read more.
Five compounds were isolated from root extracts of Rhodiola kirilowii: arbutin, epigallocatechin gallate, rhodiocyanoside A, fructopyrano-(1-4)-glucopyranose and lotaustralin. The first four compounds were found in this plant for the first time. Lotaustralin, salidroside, daucosterol and tyrosol were already described to be contained. Especially salidroside (as a Rhodiola marker compound) could not be detected in our samples. The structures were established by NMR studies. Full article
Open AccessArticle
Utility of 6-Amino-2-thiouracil as a Precursor for the Synthesis of Pyrido[2,3-d]Pyrimidines and their in vitro and in vivo Biological Evaluation
Sci. Pharm. 2007, 75(1), 9-28; https://doi.org/10.3797/scipharm.2007.75.9 - 30 Mar 2007
Cited by 10 | Viewed by 664
Abstract
The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azamethine derivatives 3a,b. The formed azamethines underwent [4+2] cycloaddition with enaminones 4a-c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a-f and 11a,b respectively. On the other hand the interaction of 3a,b [...] Read more.
The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azamethine derivatives 3a,b. The formed azamethines underwent [4+2] cycloaddition with enaminones 4a-c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a-f and 11a,b respectively. On the other hand the interaction of 3a,b with acetylene derivatives 12a,b, 14 afforded the corresponding pyrido[2,3-d]pyrimidine 13a-d and 16a,b respectively. The synthesized 2-azadiene 18 failed to add either electron-poor or push-pull dienophile. The in vitro antimicrobial activity of some of the newly synthesized compounds was examined. All the tested compounds proved to be active as antibacterial and antifungal agents. Also the in vivo antitumor activity of compounds 8a, 11b, 13a,d and 16b against lung (H460) and liver (HEPG2) carcinoma cells was examined. Compounds 8a, 16b showed moderate activity against lung carcinoma cell line (H460). Full article
Open AccessArticle
Synthesis and Biological Activity of 5-Aminopyrimidineterpenes
Sci. Pharm. 2007, 75(1), 1-8; https://doi.org/10.3797/scipharm.2007.75.1 - 30 Mar 2007
Cited by 2 | Viewed by 508
Abstract
The synthesis of 4-arylamine-6-methyl-2-phenyl-5- methylamine-terpene derivatives was presented and an antibacterial activity of the obtained compounds was investigated. Full article
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