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Diseases, Volume 9, Issue 2

June 2021 - 21 articles

Cover Story: Oxidative stress and exacerbated inflammation are the foremost standard processes responsible for the development and advancement of multiple pathologies. Together with cytokine storms, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these factors. The wisdom of nature allows mitochondria to maintain optimal cell homeostasis through their receptors and enzymes, that respond to endogenous hormones and nutritional substances found in natural foods. Melatonin and micronutrients contribute as part of the therapy of oxidative/inflammatory diseases through their mitochondrial actions. Prospectively, it would be interesting to investigate the potential synergistic beneficial effects of simultaneous administration of micronutrients and melatonin in patients with oxidative/inflammatory diseases of different degrees of severity. View this paper.
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Articles (21)

  • Article
  • Open Access
7 Citations
4,519 Views
20 Pages

A Bibliometric Meta-Analysis of Colistin Resistance in Klebsiella pneumoniae

  • Ozioma Forstinus Nwabor,
  • Pawarisa Terbtothakun,
  • Supayang P. Voravuthikunchai and
  • Sarunyou Chusri

Colistin is a last resort antibiotic medication for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In recent years, various mechanisms have been reported to mediate colistin resistance in K. pneumoniae. This study r...

  • Article
  • Open Access
2 Citations
4,164 Views
15 Pages

Prognostic Factors, Survival Analyses and the Risk of Second Primary Cancer: A Population-Based Study on Burkitt Lymphoma/Leukemia

  • Ana M. Della Rocca,
  • Fernanda S. Tonin,
  • Mariana M. Fachi,
  • Alexandre F. Cobre,
  • Vinicius L. Ferreira,
  • Letícia P. Leonart,
  • Giovanna Steffenello-Durigon,
  • Joanita A. G. Del Moral,
  • Luana Lenzi and
  • Roberto Pontarolo

Burkitt lymphoma/leukemia (BL/L) is an aggressive oncohematological disease. This study evaluated the population-based prognosis and survival on BL/L as well as if BL/L behaved as a risk factor for the development of second primary cancers (SPCs) and...

  • Article
  • Open Access
8 Citations
3,865 Views
15 Pages

The role of inflammation in neuroendocrine tumors is poorly known. The purpose of this study was to characterize the densities of CD3+, CD8+, CD4+ and FOXP3+ T cells in small bowel neuroendocrine tumors (SB-NETs), SB-NET lymph node metastases and gas...

  • Article
  • Open Access
1 Citations
2,993 Views
11 Pages

This retrospective cross-sectional database study used 2018 Medical Expenditure Panel Survey data to quantify and assess differences in healthcare expenditures between opioid users and non-users among a non-institutionalized sample of older (≥50 year...

  • Case Report
  • Open Access
2 Citations
5,779 Views
10 Pages

Light chain amyloidosis (AL) causes irreversible multi-organ damage if not diagnosed early in the disease process. Fat pad biopsy is thought to be a highly sensitive screening test in systemic AL cases, especially if greater than three organs are inv...

  • Article
  • Open Access
48 Citations
13,928 Views
13 Pages

Incidence and Characteristics of Kidney Stones in Patients on Ketogenic Diet: A Systematic Review and Meta-Analysis

  • Prakrati Acharya,
  • Chirag Acharya,
  • Charat Thongprayoon,
  • Panupong Hansrivijit,
  • Swetha R. Kanduri,
  • Karthik Kovvuru,
  • Juan Medaura,
  • Pradeep Vaitla,
  • Desiree F. Garcia Anton and
  • Poemlarp Mekraksakit
  • + 3 authors

Very-low-carbohydrate diets or ketogenic diets are frequently used for weight loss in adults and as a therapy for epilepsy in children. The incidence and characteristics of kidney stones in patients on ketogenic diets are not well studied. Methods: A...

  • Review
  • Open Access
27 Citations
5,306 Views
11 Pages

Saliva Exhibits High Sensitivity and Specificity for the Detection of SARS-COV-2

  • Ibrahim Warsi,
  • Zohaib Khurshid,
  • Hamda Shazam,
  • Muhammad Farooq Umer,
  • Eisha Imran,
  • Muhammad Owais Khan,
  • Paul Desmond Slowey and
  • J. Max Goodson

In the wake of the COVID-19 pandemic, it is crucial to assess the application of a multitude of effective diagnostic specimens for conducting mass testing, for accurate diagnosis and to formulate strategies for its prevention and control. As one of t...

  • Article
  • Open Access
4 Citations
3,571 Views
8 Pages

Serological and Molecular Evidence of Patients Infected with Anaplasma phagocytophilum in Mexico

  • Carolina Guadalupe Sosa-Gutierrez,
  • Maria Almudena Cervantes-Castillo,
  • Ramon Laguna-Gonzalez,
  • Laura Yareli Lopez-Echeverria,
  • Deyanira Ojeda-Ramírez and
  • Mayra Oyervides

Human granulocytic Anaplasmosis (HGA), is a tick-borne infectious disease transmitted by ticks, resulting in acute feverish episodes. The etiological agent is the bacteria Anaplasma phagocytophilum; which is spread by ticks of the genus Ixodes spp. t...

  • Article
  • Open Access
11 Citations
4,217 Views
15 Pages

Background: The COVID-19 pandemic has been characterized by wide variations in mortality across nations. Some of this variability may be explained by medical comorbidities such as obesity and depression, both of which are strongly correlated with die...

  • Article
  • Open Access
14 Citations
5,756 Views
12 Pages

Alignment of Qx100/Qx200 Droplet Digital (Bio-Rad) and QuantStudio 3D (Thermofisher) Digital PCR for Quantification of BCR-ABL1 in Ph+ Chronic Myeloid Leukemia

  • Carmen Fava,
  • Simona Bernardi,
  • Enrico Marco Gottardi,
  • Roberta Lorenzatti,
  • Laura Galeotti,
  • Francesco Ceccherini,
  • Francesco Cordoni,
  • Filomena Daraio,
  • Emilia Giugliano and
  • Aleksandar Jovanovski
  • + 9 authors

In recent years, the digital polymerase chain reaction has received increasing interest as it has emerged as a tool to provide more sensitive and accurate detection of minimal residual disease. In order to start the process of data alignment, we asse...

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Diseases - ISSN 2079-9721