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Anti-Diabetic Medications for the Pharmacologic Management of NAFLD

Department of Medicine, Roger Williams Medical Center, Providence, RI 02908, USA
Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA
Department of Medicine, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch Road # 210, Stanford, CA 94304, USA
Author to whom correspondence should be addressed.
Diseases 2018, 6(4), 93;
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 28 September 2018 / Published: 3 October 2018
PDF [222 KB, uploaded 3 October 2018]


As a chronic disease encompassing a wide spectrum of liver-related histologic damage, nonalcoholic fatty liver disease (NAFLD) is becoming a global epidemic with significant impacts on all-cause morbidity and mortality. Insulin resistance and type 2 diabetes mellitus predispose individuals to NAFLD and related complications. Therefore, timely intervention with anti-diabetic medications may prevent and delay the development of NAFLD or have a therapeutic implication. The focus of this review is to evaluate the evidence supporting the efficacy of anti-diabetic medications in the treatment of NAFLD. While many of these anti-diabetic agents have shown to improve biochemical parameters, their effect on hepatic histology is limited. Among anti-diabetic medications, only thiazolidinediones and glucagon-like peptide-1 receptor agonists demonstrate significant improvement in hepatic histology. View Full-Text
Keywords: NAFLD; NASH; anti-diabetic medication; metformin; TZD NAFLD; NASH; anti-diabetic medication; metformin; TZD
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cholankeril, R.; Patel, V.; Perumpail, B.J.; Yoo, E.R.; Iqbal, U.; Sallam, S.; Shah, N.D.; Kwong, W.; Kim, D.; Ahmed, A. Anti-Diabetic Medications for the Pharmacologic Management of NAFLD. Diseases 2018, 6, 93.

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