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Diseases 2018, 6(3), 80; https://doi.org/10.3390/diseases6030080

Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD

1
Drexel University College of Medicine, Philadelphia, PA 19129, USA
2
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
3
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA
4
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA
*
Author to whom correspondence should be addressed.
Received: 9 August 2018 / Revised: 4 September 2018 / Accepted: 7 September 2018 / Published: 10 September 2018
Full-Text   |   PDF [385 KB, uploaded 13 September 2018]

Abstract

Our aim is to review the efficacy of various herbs and supplements as a possible therapeutic option in the treatment and/or prevention of nonalcoholic fatty liver disease (NAFLD). We performed a systematic review of medical literature using the PubMed Database by searching the chemical names of many common herbs and supplements with “AND (NAFLD or NASH)”. Studies and medical literature that discussed the roles and usage of herbs and supplements in NAFLD and nonalcoholic steatohepatitis (NASH) from inception until 20 June 2018 were reviewed. Many studies have claimed that the use of various herbs and supplements may improve disease endpoints and outcomes related to NAFLD and/or NASH. Improvement in liver function tests were noted. Amelioration or reduction of lobular inflammation, hepatic steatosis, and fibrosis were also noted. However, well-designed studies demonstrating improved clinical outcomes are lacking. Furthermore, experts remain concerned about the lack of regulation of herbs/supplements and the need for further research on potential adverse effects and herb–drug interactions. In conclusion, preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory, anti-apoptotic, and anti-adipogenic properties that may help curtail the progression of NAFLD/NASH. Clinical trials testing the safety and efficacy must be completed before widespread use can be recommended. View Full-Text
Keywords: NAFLD; NASH; nonalcoholic fatty liver disease; herb; silymarin; resveratrol; green tea; coffee; turmeric; garlic; Ginkgo biloba; cannabinoids; fish oil NAFLD; NASH; nonalcoholic fatty liver disease; herb; silymarin; resveratrol; green tea; coffee; turmeric; garlic; Ginkgo biloba; cannabinoids; fish oil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Perumpail, B.J.; Li, A.A.; Iqbal, U.; Sallam, S.; Shah, N.D.; Kwong, W.; Cholankeril, G.; Kim, D.; Ahmed, A. Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD. Diseases 2018, 6, 80.

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