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Diseases 2018, 6(2), 42; https://doi.org/10.3390/diseases6020042

Viral Vectors in Gene Therapy

PanTherapeutics, CH1095 Lutry, Switzerland
Received: 30 April 2018 / Revised: 15 May 2018 / Accepted: 16 May 2018 / Published: 21 May 2018
(This article belongs to the Special Issue Gene Therapy)
Full-Text   |   PDF [285 KB, uploaded 21 May 2018]

Abstract

Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular, muscular, hematologic, ophthalmologic, and infectious diseases and different types of cancer. Recent development in the area of immunotherapy has provided both preventive and therapeutic approaches. Furthermore, gene silencing generating a reversible effect has become an interesting alternative, and is well-suited for delivery by viral vectors. A number of preclinical studies have demonstrated therapeutic and prophylactic efficacy in animal models and furthermore in clinical trials. Several viral vector-based drugs have also been globally approved. View Full-Text
Keywords: prevention; therapy; immunotherapy; gene silencing; clinical trials; approved drugs prevention; therapy; immunotherapy; gene silencing; clinical trials; approved drugs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lundstrom, K. Viral Vectors in Gene Therapy. Diseases 2018, 6, 42.

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