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Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin

The Procter and Gamble Company, Mason Business Center, Mason, OH 45040, USA
23andMe, Sunnyvale, CA 94086, USA
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 49;
Received: 28 May 2020 / Revised: 12 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Individuals suffering from sensitive skin often have other skin conditions and/or diseases, such as fair skin, freckles, rosacea, or atopic dermatitis. Genome-wide association studies (GWAS) have been performed for some of these conditions, but not for sensitive skin. In this study, a total of 23,426 unrelated participants of European ancestry from the 23andMe database were evaluated for self-declared sensitive skin, other skin conditions, and diseases using an online questionnaire format. Responders were separated into two groups: those who declared they had sensitive skin (n = 8971) and those who declared their skin was not sensitive (controls, n = 14,455). A GWAS of sensitive skin individuals identified three genome-wide significance loci (p-value < 5 × 10−8) and seven suggestive loci (p-value < 1 × 10−6). Of the three most significant loci, all have been associated with pigmentation and two have been associated with acne. View Full-Text
Keywords: sensitive skin; genome-wide association studies sensitive skin; genome-wide association studies
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Farage, M.A.; Jiang, Y.; Tiesman, J.P.; Fontanillas, P.; Osborne, R. Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin. Cosmetics 2020, 7, 49.

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