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Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin

1
The Procter and Gamble Company, Mason Business Center, Mason, OH 45040, USA
2
23andMe, Sunnyvale, CA 94086, USA
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 49; https://doi.org/10.3390/cosmetics7020049
Received: 28 May 2020 / Revised: 12 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Individuals suffering from sensitive skin often have other skin conditions and/or diseases, such as fair skin, freckles, rosacea, or atopic dermatitis. Genome-wide association studies (GWAS) have been performed for some of these conditions, but not for sensitive skin. In this study, a total of 23,426 unrelated participants of European ancestry from the 23andMe database were evaluated for self-declared sensitive skin, other skin conditions, and diseases using an online questionnaire format. Responders were separated into two groups: those who declared they had sensitive skin (n = 8971) and those who declared their skin was not sensitive (controls, n = 14,455). A GWAS of sensitive skin individuals identified three genome-wide significance loci (p-value < 5 × 10−8) and seven suggestive loci (p-value < 1 × 10−6). Of the three most significant loci, all have been associated with pigmentation and two have been associated with acne. View Full-Text
Keywords: sensitive skin; genome-wide association studies sensitive skin; genome-wide association studies
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MDPI and ACS Style

Farage, M.A.; Jiang, Y.; Tiesman, J.P.; Fontanillas, P.; Osborne, R. Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin. Cosmetics 2020, 7, 49.

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