The pursuit of youthful, healthy skin remains one of the most compelling drivers in the cosmetics industry. Anti-aging claims dominate consumer expectations, and scientific research continues to evolve to meet these demands. This Special Issue of Cosmetics—Skin Anti-Aging Strategies—brings together novel insights, innovative technologies, and modern approaches to address the multifaceted nature of skin aging.
Skin aging is influenced by intrinsic factors like genetic predisposition and cellular senescence, as well as extrinsic stressors including UV radiation, pollution, and lifestyle habits [1]. Climate change and regional variations further complicate this landscape, emphasizing the need for tailored solutions across diverse populations and ethnicities.
Traditional anti-aging strategies have focused on antioxidants [2], anti-inflammatory mechanisms [3], and extracellular matrix protection [4]. Recent advances highlight emerging frontiers: the role of the skin microbiome [5], senolytic interventions [6], exosome-based therapies [7], and neurocosmetics that integrate emotional well-being into skincare [8], as well as skin rejuvenation and longevity claims [9].
This Special Issue features 14 peer-reviewed contributions that span molecular pathways, biochemical mechanisms, and clinical applications. More specifically, this includes:
- Bioactive Ingredients: Studies on naturals as well as peptides demonstrate multifunctional benefits—antioxidant, anti-inflammatory, and anti-melanogenic properties—underscoring the power of nature-inspired actives.
- Advanced Delivery Systems and formulation: Research on composite nanocarriers and innovative formulations illustrates how technology enhances efficacy and consumer experience.
- Nutraceutical Approaches: Clinical trials on collagen peptide supplementation reaffirm the synergy between oral and topical interventions for skin health.
- Device driven skin care and AI: The use of LED-based phototherapy or the integration of artificial intelligence reflect the industry’s commitment to innovation.
Beyond scientific evidence, this Special Issue is meant for collaboration and knowledge exchange, driving progress toward effective and sustainable anti-aging solutions.
We invite researchers, formulators, and specialists in the field to explore these contributions and join the dialogue shaping next-generation anti-aging strategies.
Acknowledgments
During the preparation of this manuscript, the author used Copilot Pro for the purposes of generating text. The author has reviewed and edited the output and takes full responsibility for the content of this publication.
Conflicts of Interest
The author declares no conflict of interest.
References
- Wyles, S.P.; Maredia, H.S.; Ansaf, R.B.; Dweydari, M.R.; Hurt, R.T.; Bonnes, S.L.; Khosla, S.; LeBrasseur, N.K.; Draelos, Z.D.; Davis, M.D. Skinspan(TM): A Healthy Longevity Framework for Skin Aging. Mayo Clin. Proc. 2025, 100, 1976–1991. [Google Scholar] [CrossRef] [PubMed]
- Farris, P.; Krol, Y. Under Persistent Assault: Understanding the Factors that Deteriorate Human Skin and Clinical Efficacy of Topical Antioxidants in Treating Aging Skin. Cosmetics 2015, 2, 355–367. [Google Scholar] [CrossRef]
- Baechle, J.J.; Chen, N.; Makhijani, P.; Winer, S.; Furman, D.; Winer, D.A. Chronic inflammation and the hallmarks of aging. Mol. Metab. 2023, 74, 101755. [Google Scholar] [CrossRef] [PubMed]
- Sparavigna, A. Role of the extracellular matrix in skin aging and dedicated treatment—State of the art. Plast. Aesthetic Res. 2020, 7, 14. [Google Scholar] [CrossRef]
- Sfriso, R.; Egert, M.; Gempeler, M.; Voegeli, R.; Campiche, R. Revealing the secret life of skin with the microbiome you never walk alone. Int. J. Cosmet. Sci. 2020, 42, 116–126. [Google Scholar] [CrossRef] [PubMed]
- Pils, V.; Ring, N.; Valdivieso, K.; Lämmermann, I.; Gruber, F.; Schosserer, M.; Grillari, J.; Ogrodnik, M. Promises and challenges of senolytics in skin regeneration, pathology and ageing. Mech. Ageing Dev. 2021, 200, 111588. [Google Scholar] [CrossRef] [PubMed]
- Thakur, A.; Shah, D.; Rai, D.; Parra, D.C.; Pathikonda, S.; Kurilova, S.; Cili, A. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics 2023, 10, 65. [Google Scholar] [CrossRef]
- Rizzi, V.; Gubitosa, J.; Fini, P.; Cosma, P. Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation. Cosmetics 2021, 8, 66. [Google Scholar] [CrossRef]
- Klinngam, W.; Chaiwichien, A.; Osotprasit, S.; Ruktanonchai, U.; Kanlayavattanakul, M.; Lourith, N.; Wongrakpanich, A.; Teeranachaideekul, V.; Iempridee, T. Longevity cosmeceuticals as the next frontier in cosmetic innovation: A scientific framework for substantiating product claims. Front. Aging 2025, 6, 1586999. [Google Scholar] [CrossRef] [PubMed]
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