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Cosmetics 2014, 1(2), 75-81;

The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide

Department II, Faculty of Pharmacy, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Square E. Murgu No. 2, Timişoara 300041, Romania
Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 21 March 2014 / Accepted: 31 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Selected Papers from ISBS/SICC 1st Joint International Congress)
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Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons: (1) they are small molecules, easily penetrable in the skin and (2) they are able to induce a very specific action, because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides. This group of cosmeceutics includes the botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptid-3 (Leuphasyl). The latter is less known and has been less studied. This substance inhibits the neuromuscular synapses in the mimic muscles, acting as enkephalins. It links the enkephalin receptor to nervous cells, thereby modulating the release of acetylcholine in synaptic space. This cellular activity will be translated in vivo in a relaxation of the muscle and a reduction of expression wrinkles. The aim of our study is to evaluate the optimal concentration of Leuphasyl for skin application at the mimic muscle level, the efficiency and the safety of this peptide. We formulated three emulsions of different concentrations (0.5%, 1%, 2%) which were applied to the skin, at the level of mimic muscles (1) at the eyebrows zone (above the corrugator supercilii muscle) and (2) at the periorbital zone (above the orbicularis oculi muscle). We evaluated the regression of the wrinkles between the eyebrows using an imagistic method: pro-derm Analyser. The study is of interest to discussions concerning how to apply these kinds of cosmetic products at the mimic muscle skin level and not at the level of the wrinkles. View Full-Text
Keywords: wrinkles; aging skin; botox-like peptides wrinkles; aging skin; botox-like peptides

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dragomirescu, A.O.; Andoni, M.; Ionescu, D.; Andrei, F. The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide. Cosmetics 2014, 1, 75-81.

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